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Welcome to UISpace, The University of Ibadan Institutional Repository. A collection of theses, articles, books, videos, images, lectures, papers, data sets and all types of digital content originating from the University of Ibadan Nigeria. This repository is managed by the Kenneth Dike Library University of Ibadan, Nigeria.
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Recent Submissions
Spinal meningioma: clinical profile and outcome of surgical management
(The Pan African Medical Journal, 2022) Oyemolade, T. A.; Adeolu, A. A.; Malomo, A. O.; Shokunbi, M. T.; Salami, A. A.
Spinal meningiomas are relatively rare tumors with often favorable surgical outcomes. There is a paucity of data on spinal meningiomas in the Nigerian literature. This study was designed to evaluate the incidence, anatomical distribution, and outcome of surgical treatment of spinal meningiomas at our center.
This was a retrospective study of patients who underwent surgery for spinal meningioma during the study period. Data were obtained from case notes, operation, and pathology registers. Univariate analysis was performed using SPSS version 15 (SPSS Science Inc, Chicago, IL, USA).
There were 11 patients in the study, all females, with an age range of 26–65 years. All patients presented with motor deficits. Four patients (36.4%) presented within six months of symptom onset, while symptom duration exceeded one year in five patients (45.5%). Preoperative functional grading was Frankel A in 2 patients (18.2%), Frankel B and C in 4 patients each (36.4%), and Frankel D in 1 patient (9.1%). Tumor locations were thoracic in six patients (54.5%), cervical in 2 patients (18.2%), and cervicothoracic in 3 patients (27.3%). All patients underwent gross total tumor resection. Postoperative neurological improvement occurred in 7 patients (63.6%), while 4 patients (36.4%) remained neurologically unchanged.
Gross total tumor resection was achieved in all cases with satisfactory functional outcomes.
Postmortem Heart Weights and Valvular Circumference of Apparently Healthy Adult Nigerian Decedents - an Observational Study
(The Brazilian Society of Anatomy (SBA), 2022) Ezenkwa, U. S.; Salami, A. A.; Adeoye, A. O.; Ogunbiyi, O. J.
Introduction: Organ weights at postmortem examination of deceased Nigerians are compared with those of Caucasians to determine pathologies and cause of death. Indigenous data are needed because of differences in race and lifestyle.
Materials and Methods: This was an eleven-year retrospective study. Postmortem findings and summarized clinical notes of deceased Nigerians archived in the Department of Pathology, University College Hospital, Ibadan, from January 1, 2008 to December 31, 2018 were reviewed. Inclusion criteria were age 18–70 years, traumatic or sudden unexpected death with no pathology in the heart, and no history or postmortem features of hypertension. Data on age, gender, cause of death, body length, heart weights, heart valve circumferences, and ventricular wall thickness were retrieved. Descriptive statistics, Student’s t-test, and regression analysis were performed using SPSS version 20. Confidence limits were set at p < 0.05.
Results: Eighty-five cases fulfilled the criteria, comprising 64 males and 21 females, with mean ages of 39.1 ± 13.8 years and 37.2 ± 11.0 years, respectively. The mean heart weights for males and females differed significantly, with means of 310.8 ± 40.3 g (220–405 g) and 261.3 ± 34.0 g (200–325 g), respectively (p < 0.0001). The mean body lengths also differed significantly, with males at 1.70 ± 0.1 m and females at 1.62 ± 0.1 m (p < 0.002). There was no significant difference in age between males and females (p > 0.05). Multiple regression analysis suggested that only gender was a likely predictor of heart weight (p < 0.001). The mean circumferences of the tricuspid, mitral, pulmonary, and aortic valves were 11.2 cm, 9.3 cm, 7.2 cm, and 6.4 cm, respectively, while the mean left and right ventricular wall thicknesses were 1.3 cm and 0.3 cm, respectively.
Conclusion: Heart weights and valvular circumferences of apparently healthy adult Nigerians differ by gender and show ranges beyond values reported in other populations. These findings highlight the need for locally derived nomograms for postmortem assessments.
Histomorphological Spectrum and Trend of Spinal Neoplastic Lesions: A Single Institutional 40-year review
(Zambia Medical Association (supported via African Journals OnLine), 2021) Salami, A. A.; Nwadiokwu, J. I.; Iwuagwu, E. I.; Ajani, M. A.; Balogun, A. J.; Oyemolade, A. T.; Adeolu, A. A.
Objectives: Spinal tumors are much less common compared to brain neoplasms. In our setting, due to poor data collection, underreporting, and limited presentation to medical facilities, studies on spinal tumors are sparse. Consequently, there is a lack of data on the frequency of spinal tumors in a predominantly Black population. Previous studies in our environment reported spinal tumors to be infrequent, with extramedullary tumors being more common. This study examines the histomorphological spectrum of spinal tumors in an African setting, comparing it with previous observations to determine possible changes over the decades.
Methods: Data were obtained from hospital records of patients over a forty-year period. Information collected included patients’ age, gender, and histomorphological data of all neoplastic spinal lesions. The data were analyzed using SPSS version 20 statistical software.
Results: Tumors were more common between the third and sixth decades of life. There was a slight male preponderance, with a male-to-female ratio of 1.2:1. Meningiomas were the most common tumors seen during the study period, contrasting with previous studies that had shown Burkitt lymphoma as predominant. The data also showed a steady rise in the number of cases over the study period, suggesting increased hospital presentations and more surgical interventions.
Conclusion: This study showed differences in patient demographics and histological tumor types compared to previous reports. These changes are likely due to better awareness among patients and improved diagnostic facilities.
Prevalence and Review of Pathological Anatomy of Gestational Choriocarcinoma in Ibadan
(JournalGurus (on behalf of the Society of Gynaecology and Obstetrics of Nigeria), 2022) Awosusi, B. L.; Ajani, M. A.; Adegoke, O. O.; Salami, A. A.; Okolo, C. A.
Objectives: Gestational choriocarcinoma (GCC) is a highly malignant epithelial tumor arising from the trophoblast of any type of gestational event, most often a complete hydatidiform mole. Choriocarcinoma is the most aggressive form of gestational trophoblastic neoplasia due to its rapid growth and metastatic potential. This study reviewed all cases of GCC seen at the University College Hospital, Ibadan.
Methods: This was a 20-year retrospective hospital-based study designed to review all histologically diagnosed cases of choriocarcinoma registered at the Department of Pathology, University College Hospital (UCH), Ibadan, Nigeria, from 1st January 1997 to 31st December 2016. Clinicopathological data were extracted from the departmental surgical day book, ward register, Department of Medical Records, and Cancer Registry. The data were analyzed using the Statistical Package for Social Sciences (SPSS), version 22. Results were presented in tables, relative frequencies, and group percentages.
Results: One hundred and eighty-three cases of gestational trophoblastic disease were histologically diagnosed within the study period, of which 36 cases were GCC, accounting for 19.7%. Of all the cases, 55.6% were received as endometrial biopsies, 33.3% as hysterectomy specimens, 8.3% as cervical biopsies, and 2.8% as an anterior vaginal wall mass. Choriocarcinoma occurred in the age range of 20 to 50 years, with the majority of cases occurring in the third decade of life.
Conclusion: Gestational choriocarcinoma remains the most common form of gestational trophoblastic neoplasia in our environment. Awareness of this tumor, along with a high index of suspicion, is essential for accurate diagnosis and effective patient management.
Maternal Near-Miss Due to Unsafe Abortion and Associated Short-Term Health and Socio-Economic Consequences in Nigeria
(Women's Health and Action Research Centre (WHARC), 2015) Prada, E.; Bankole, A.; Oladapo, O. T.; Awolude, O. A.; Adewole, I. F.; Onda, T.
Little is known about maternal near-miss (MNM) due to unsafe abortion in Nigeria. We used the WHO criteria to identify near-miss events and the proportion due to unsafe abortion among women of childbearing age in eight large secondary and tertiary hospitals across the six geo-political zones. We also explored the characteristics of women with these events, delays in seeking care and the short-term socioeconomic and health impacts on women and their families. Between July 2011 and January 2012, 137 MNM cases were identified of which 13 or 9.5% were due to unsafe abortions. Severe bleeding, pain and fever were the most common immediate abortion complications. On average, treatment of MNM due to abortion costs six times more than induced abortion procedures. Unsafe abortion and delays in care seeking are important contributors to MNM. Programs to prevent unsafe abortion and delays in seeking postabortion care are urgently needed to reduce abortion related MNM in Nigeria.