Babatunde, E. O.Odokhekpen, V.2026-01-282021-013115-5863ui_art_Odokhekpen_assessment_2021https://repository.ui.edu.ng/handle/123456789/11672Nigerian School Health Journal 33(1), pp. 37-48Drug is any chemical substance which when taking interact with tissues to modify the biochemical process such as perceptions, cognition, mood, behaviour and general body functions. It is a major public health concern that impacts not just the user but also the user's family and-is becoming increasingly problematic in Nigeria. The study evaluated parental drug addiction, drug abuse and drug misuse on children self-esteem in Nigeria. Four research questions were answered using ex-post facto research type. Population comprised all addicted parents in Southwest, Nigeria. Fisher’s formula was used to sample 400 participants. Three instruments; Drug Addiction Prevalence Questionnaire (DAPQ), r-0.78, Drug Addiction Effect on Children Questionnaire (DAECQ), r=0.80 and Rosenberg Self-esteem Scale (RSS), r-0.83 were used for data collection. Data collected was analyzed using descriptive and inferential statistics at 0.05 level of significance. Result revealed that 175(43,8%) males were addicted, 39% and 14.5% abuse and misuse drug respectively. There was significant relationship of the three independent variables: parental drug addiction (r = 0.259, p < 0.05), drug abuse (r =.698, p < 0.05) and drug misuse (r = .151, p < 0.05) on children self- ' esteem. The entire independent variables: parental drug addiction (fi =0.205, t = 6.512, p < 0.05), drug abuse (fi = 0.300, t - 8.431, p < 0,05) and drug misuse (f - 0,119, t = 4,069, p < 0.05) contributed significantly. The result showed that the effect constitutes one of the most deadly menaces faced by Nigerians today that must be eradicated. The-study recommends aggressive sensitization programmes.enDrug addictionDrug abuseDrug misuseChildren self-esteemArticle