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Management outcome of premature rupture of membranes in a tertiary facility in South Western Nigeria. Annals Ibadan
(2021) Suleiman, B. K.; Bello, O. O.; Tijani, A. M.; Oluwasola, T. A. O.
Background: Pre-labour rupture of membranes (PROM) contributes immensely to the potential risk of maternal morbidity and mortality.
Objective: To explore the incidence and management outcome of PROM at Ladoke Akintola University of Technology Teaching Hospital (LTH), Ogbomoso, Nigeria
Methods: A retrospective study of 61 cases of PROM managed at LTH, Ogbomoso over a 3-year period. Information on the socio-demographics and obstetrics characteristics, management instituted, and outcomes were obtained using a structured proforma. Data were analysed using SPSS version 20. Level of significance was set at <0.05 and 95% confidence interval.
Results: The incidence of PROM was 4.1% with a perinatal mortality rate of 0.18 per 1000 deliveries. Twenty (33%) were pre-term while 41 (67%) were term PROM with 10% of the perinatal death occurring among those with preterm PROM. The mean age of the women was 36.9 (SD=2.1) years and median parity of 1(range 1-5) children. There was a significant association between the women’s gestational age at which PROM occurred with the latency
period (p< 0.001). Fetal birth weight, apgar score and neonatal intensive care unit (NICU) admission were all significantly associated with the gestational age at which PROM occurred (p<0.05). There was a significant difference between the intervention instituted and mode of delivery (p=0.009).
Conclusion: The incidence of PROM at term was high and conservative/ expectant management was effective. The latency period and fetal outcomes such as birth weight, apgar score and NICU admission were determined by the gestational age at which PROM occurred.
Challenges and prospects of neoadjuvant chemotherapy for gynaecologic malignancies in resource-limited settings.
(2021) Oluwasola, T. A. O.
Administration of chemotherapeutic agents followed by interval debulking surgery has been reported to be non-inferior to primary debulking surgery (PDS) and adjuvant chemotherapy. Limitation of human and nonhuman facilities for optimal surgical intervention makes Neoadjuvant chemotherapy (NACT) a desirable alternative in resource-limited settings. NACT is gradually becoming an acceptable alternative in centers with limited facilities for comprehensive PDS. Moreover, some recent studies have described NACT as being non- inferior to the gold standard of PDS although it is important to note that strict patient selection remains an important criterion and serve as the hallmark for the success of NACT This review aimed to explore the essence of NACT for gynecological malignancies, its challenges as well as prospects for resource-limited settings
Blocking the loopholes: Nigeria’s post-war import control
(2025) Abolorunde, A. S.
The end of the Second World War in 1945 ushered in an important epoch in Nigeria’s economic history and this has attracted the interrogation of various historical developments of her post war experience by scholars. This became imperative because the end of the war opened a new chapter in the history of the country. The period marked the beginning of socio-economic and political transformation of colonial Nigeria. To this end, scholars from various disciplines such as economics, sociology, political science and history have paid adequate attention to the country’s post-war events. These include, the decolonisation of the country’s economy through the prism of economics as a discipline, political decolonization, agitations against discriminatory practices against Nigeria’s investors and transfer of power from the British to Nigeria’s political elite. Similarly, scholars have looked at the contributory roles of Nigerians both military and civilians to the success of British prosecution of the Second World War. However, most of these works did not directly examine how the country regulated her imports through the expansion of industries after the Second World War in 1945 up to 1954 when the colonial government granted the three regions greater autonomy to take certain economic decisions with the limited inputs of the colonial regime. This neglect limits our understanding of Nigeria’s post-war economic history. The paper argues that import control through the expansion of industries was deployed as one of the strategies of the decolonisation process which began in the country after 1945.
Mutation analysis of p53 gene in cervical cancer and useful polymorphic variants in exons 3 and 4
(2021) Gbadegesin, M. A.; Omotosho, O. E.; Oluwasola, T. A. O.; Okolo, C. A.; Oluwasola, A. O.; Soremekun, O.; Ogun, G. O.; Abideen O. O.; Oyeronke A. O.
Background: Factors contributing to the pathogenesis and progression of cervical cancer include poor attitude to screening and health intervention, late presentation, among others. Mutations in p53 gene have been attributed to several cancer cases. The present study was designed to find relationships between the mutation patterns in p53 gene and cervical carcinoma staging. Such knowledge could contribute to early diagnosis of cervical cancer.
Results: From the sequence analysis of p53 gene fragment isolated by polymerase chain reactions (PCR), nineteen (19) polymorphic variants were identified. Missense mutations occurred in 47% of the samples, 32% were silent mutations, 16% were frameshift mutations and 5% nonsense mutations. Socio-biological characteristics of the study participants revealed that 60% have husbands with multiple sexual partners and that only 23.3% of the participants have ever had the Papanicolaou (Pap) smear test prior to diagnosis, whilst 20% were unaware of the screening test.
Conclusions: Increased severity of cervical carcinoma staging as revealed from the histopathological analysis was found to be associated with accumulation of higher levels of mutations in the p53 gene. Molecular analysis of p53 gene mutations may prove useful as a screening biomarker for cervical cancer.
Estimating admission lifetime and survival for gynaecological cancers at the University College Hospital, Ibadan using Cox regression model.
(2021) Folorunso, S. A.; Oluwasola, T. A. O.; Chukwu, A. U.
Objective: To estimate the admission lifetime of gynaecological cancer patients in the University College Hospital (UCH), Ibadan and its implication to management and overall outcome using the Cox regression model.
Methods: Descriptive and cox regression model in survival analysis were used to analyze data from 823 patients with gynecological malignancies who were treated at the UCH, Ibadan between January 1 1995 and December 31, 2014. The outcome variable for this study was the admission life-time (in days). The variables collected were limited to the age of patients, types of
cancer and patients’ status. The study employed some model criteria such as p-value, log rank test, Gehan-Wilcoxon test, Concordance index, R-square, likelihood ratio test, Wald test and score test to check for the efficiency of the results.
Results: Of the 823 cases reviewed, 611(74.2%) were right-censored. Cervical cancer had the highest number of patients admitted with 53.5% and was commonest among patients aged 60 years and above (30.1%) while mortality was highest among patients with ovarian cancer. Ovarian cancer and age above 65 years were the only two factors that significantly affected patient’s survival experiences during their admission at the hospital.
Conclusion: Patients younger than 60 years and with other gynaecologic cancers, except ovarian, had better chances of survival over a period of 6 months as at the time of admission into the UCH, Ibadan.