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Welcome to UISpace, The University of Ibadan Institutional Repository. A collection of theses, articles, books, videos, images, lectures, papers, data sets and all types of digital content originating from the University of Ibadan Nigeria. This repository is managed by the Kenneth Dike Library University of Ibadan, Nigeria.
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Recent Submissions
Antimicrobial activity of Garcinia kola (heckel) seed extracts and isolated constituents against caries-causing microorganisms
(Ibadan Biomedical Communications Group, 2014) Ajayi, T. O.; Moody, J. O.; Fukushi, Y.; Adeyemi, T. A.; Fakeye, T. O.
Garcinia kola Heckel (Guttiferae) seed, has found use in folkloric medicine of Southern Nigeria for the treatment of toothache and prevention of dental caries. The crude ethanolic extract, chromatographic fractions and isolated constituents of Garcinia kola seed against clinical strains of dental-caries-causing and related microorganisms is being evaluated. Antimicrobial evaluations were done by testing different concentrations of the crude extract, vacuum liquid chromatographic (VLC) fractions and pure isolates against Streptococcus mutans, Streptococcus viridans and Staphylococcus aureus in already set blood agar with gentamicin as the reference standard. The zones of inhibition and minimum inhibitory concentrations (MIC) were determined as appropriate. Fraction N, eluted with (hexane: ethyl acetate 70: 30), exhibited the highest activity with MIC’s of 1.50 mgml⁻¹ and 0.33 mgml⁻¹ while the pure isolates 1 (cycloartenol) and 2 (24-methylenecycloartanol) gave MIC’s of 0.17 mgml⁻¹ and 0.38 mgml⁻¹ against Streptococcus mutans and Streptococcus viridans respectively. Isolate 3 (garcinianin) gave MIC of 1.0 mgml⁻¹ against Streptococcus mutans but there was no significant activity against Streptococcus viridans and Staphylococcus aureus. The results provide justifications for the folkloric use of Garcinia kola Heckel (Guttiferae) for dental caries-related health problems while the isolated compounds may also serve as templates for future antimicrobial drug development.
Hypoglycemic potentials of methanolic extracts of selected plant foods in alloxanized mice
(Kluwer Academic Publishers, 2003) Ogundipe, O. O.; Moody, J. O.; Akinyemi, T. O.; Raman, A.
Crude methanolic extracts of five selected edible plant foods were tested for hy poglycemic activity in alloxanized mice. Fasting blood sugar levels were reduced significantly at differing rates. The order of their antidiabetic activity were H. sabdariffa, A. occidentalis, S. americanum, V. amygdalina, G. latifolium, H. sabdariffa, A. occidentalis and S. americanum, utilized at a dose of 100 mg/kg, had similar activity as chlorpropamide (5 mg/kg), which was used as a reference standard, in that they reduced blood sugar levels in mice below the initial values.
Herbs and plants used for the management and treatment of hepatitis infections
(Scrivener Publishing LLC, 2022) Ogbole, O. O; Ajayi, T. A.; Odeku, O. A.
Water conservation techniques by Ilukuno, Ikun-Amure, and Ijan Ekiti Communities in Ekiti State, Nigeria
(Springer, 2022) Akinbobola, E. O; Ajayi, T. O.; Adeku, O. A.
Irrigation practices in farming communities in North central Nigeria.
(Springer, 2022) Sunmonu, J. T.; Ajayi, T. O.; Odeku, O. A.