UISpace
Welcome to UISpace, The University of Ibadan Institutional Repository. A collection of theses, articles, books, videos, images, lectures, papers, data sets and all types of digital content originating from the University of Ibadan Nigeria. This repository is managed by the Kenneth Dike Library University of Ibadan, Nigeria.
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Involvement of oxidative stress in municipal landfill leachate-induced toxicity in boar sperm
(Elsevier B.V., 2013) Adedara, I. A. || || || ||; Oyebiyi, O. O.; Lawal, T. A.; Adesina, A. A.; Farombi, E. O.
Exposure to leachates generated from an improperly managed hazardous waste dump sites is detrimental to human health and the ecosystem. The present study investigated the effect of Olushosun municipal landfill leachate (OMLL) on sperm characteristics and antioxidant systems in boar sperm cells. The sperm cells were incubated with the leachate at final concentrations of 0, 1, 2, 4 and 8% for 3 h at 37◦C. Sperm characteristics were monitored hourly during the incubation period whereas amino transferases activities and oxidative stress indices were determined after the incubation period. Results revealed a time- and dose-dependent decline in sperm progressive motility from 1 h post-treatment with 2, 4 and 8% OMLL whereas decreased sperm viability with elevated abnormalities were observed from2 h post-treatment with 4 and 8% OMLL when compared with control. Exposure to OMLL caused a significant increase in aminotransferases, catalase and glutathione-S-transferase activities whereas it markedly decreased superoxide dismutase and glutathione peroxidase activities without affecting glutathione level in the treated sperm cells. Co-incubation of sperm with OMLL increased the levels of hydrogen peroxide and malondialdehyde levels. In conclusion, OMLL elicited spermatotoxicity via induction of oxidative stress possibly generated through an enhanced intracellular reactive oxygen species.
Hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kola seed
(Elsevier Ireland Ltd., 2013) Farombi, E. O.; Adedara, I. A.; Oyenihi, A. B.; Ekakitie, E.; Kehinde, S.
Ethnopharmacological relevance: Garciniakola seed is commonly used in African Traditional Medicineas a remedy for liver disorders, hepatitis, bronchitis, throat infections as well as an aphrodisiac and fertility enhancing substance. Owing to the abundance of complex mixture of phenolic compounds in Garciniakola seed, there is a growing safety concern on its long-term use in folklore medicine.The present study evaluated the hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garciniakola seed.
Materials and methods: Adult male Wistar rats were randomly assigned to four groups of 10rats each and were orally administered with Garciniakola at 0, 250, 500 and 1000mg/kg for 6 consecutive weeks. Clinical observations, serum biochemistry, oxidative stress biomarkers, spermatozoa parameters and histopathological examination of the organs were assessed to monitor treatment-related adverse effects in rats.
Results: Long-term treatment of Garcinia kola had no adverse effect on the spermatozoa characteristics but significantly elevated testosterone concentration when compared to the control group. Improvement of antioxidant systems was accompanied by a significant decrease in malondialdehyde level in the liver, testes and spermatozoa of Garciniakola treated rats. Histological observation revealed that chronic administration of Garciniakola had no effect on the liver and testes at all doses when compared with control.
Conclusion: Garciniakola seed boosts the antioxidant status and exhibits no adverse effect on the liver, testes and spermatozoa after a long-term oral exposure in rats.
Perception of social media use for information service delivery in university libraries: a case study of Kenneth Dike Library, University of Ibadan
(2022-12) Ilo, P. I.; Izuagbe, R.; Iroaganachi, M. A.
As one of the first university libraries to embrace ICT adoption in the country, it was necessary to ascertain how the library is faring in terms of digital services provision using social media tools. Methodology: The survey design was applied alongside the accidental/convenient sampling technique. The population comprised 300 library patrons and library personnel in KDL. The method of data gathering was the questionnaire. Two hundred and thirty-three (233:77.7%) response rate was observed. The descriptive and inferential statistical tools were applied. Findings: patrons were positive about the provision of certain services using SMTs, but in terms of actual use, there was a lack of interest. Similarly, there was a low frequency of the use of available SMTs in the library; however, Facebook was the most utilized SMT by patrons, followed by Blog. The paper concludes that it is not enough to deploy relevant SMTs but to develop patron-focused services that will endear patrons to use them. Originality/value: It is an in-depth case study that explored patrons’ disposition towards information service delivery using available social media tools in KDL.
Kolaviron prevents ethylene glycol monoethyl ether-induced testicular apoptosis via down-regulation of stress proteins, Fas/Fas-L and caspases expressions in rats
(Informa Healthcare USA, Inc., 2013) Adedara, I. A.; Mathur, P. P.; Farombi, E. O.
This study investigated the protective role of kolaviron, a natural antioxidant biflavonoid isolated from the seed of Garcinia kola, in ethylene glycol monoethyl ether (EGEE)-induced testicular dysfunction in male rats. Adult male Wistar rats were exposed to EGEE (200 mg/kg) separately or in combination with either kolaviron (100 or 200 mg/kg) or vitamin E (50 mg/kg) for 14 days. Immunoblot analysis revealed that EGEE exposure alone significantly increased stress-inducible proteins levels. The increased protein expression of active caspases, Fas and Fas-L, was accompanied by nuclear factor kappa B downregulation and elevation of cytosolic cytochrome c level in EGEE-treated rats. In addition, the observation from immunofluorescence staining was consistent with the increased TUNEL-positive nuclei in the testes of EGEE-treated rats. Kolaviron and vitamin E significantly inhibited induction of stress proteins and germ cell apoptosis in EGEE-treated rats. Overall, kolaviron by virtue of its antioxidant and anti-apoptotic properties prevented EGEE-induced reproductive toxicity in rats.
Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats
(Elsevier B.V., 2013) Adedara, I. A.; Vaithinathan, S.; Jubendradass, R.; Mathura, P.P.; Farombi, E.O.
The study evaluated the protective role of kolaviron (an isolated biflavonoid from the seed of Garcinia kola) and vitamin E in carbendazim-induced reproductive dysfunction in male rats. Adult male Wistar rats were orally exposed to carbendazim (200 mg/kg) singly or in combi-nation with kolaviron (100 and 200 mg/kg). Exposure to carbendazim significantly decreased the activities of superoxide dismutase and catalase but markedly increased sialic acid con-centration and lipid peroxidation in the testes of rats. Western blot analysis revealed that carbendazim treatment decreased the expression of steroid acute regulatory (StAR) protein and androgen binding protein (ABP) with concomitant decrease in activities of steroido- genic enzymes. Germ cell apoptosis in carbendazim-treated rats was confirmed by TUNEL assay. However, pretreatment with kolaviron and vitamin E restored the testicular antiox- idant status and steroidogenesis and decreased apoptotic nuclei to near control level in carbendazim-treated rats. Kolaviron may prove useful in combating carbendazim-induced reproductive toxicity.