Browsing by Author "Adeleye, J."

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Pregnancy outcome in diabetic patients at University College Hospital, Ibadan
    (2003-04) Oladokun, A.; Aimakhu, C. O.; Aimakhu, C. O.; Awolude, O. A.; Olayemi, O.; Adeleye, J.
    Context: Diabetes mellitus is one of the common medical complications in pregnancy, which if not properly controlled, can lead to significant perinatal and maternal morbidity and mortality. Objective: To determine the incidence of diabetes mellitus in pregnancy in this centre, and to assess the effect of maternal glucose control on the obstetric performance as well as perinatal outcome of pregnant diabetics managed at the University Collage Hospital, Ibadan. Study Design: A review of the obstetric outcome for 49 diabetic women who delivered at the University College Hospital, U.C.H, Ibadan, Nigeria during a 1 0-year period (January, 1991 t o D ecember 2 000) i s presented. Results: The incidence rate of diabetes in pregnancy was 0.74 per 1000 deliveries per year. Most patients (89.8%) booked for antenatal care and delivery in this centre. Good control was achieved in 77.6% of patients and the mean birth weight was 3.37 ± 1.52kg. There was no significant difference in the birth weight and fetal outcome if a patient had pre-existing or gestational diabetes. However, the outcome was significantly related to the level of control. With good control there was a better Apgar score at 5 minutes, which was prognostic for fetal outcome. The perinatal mortality rate was 98/1000 births and this was significantly associated with poor control when compared with good control (p < 0.05). There was no maternal death. Conclusion: Further improvement in the management is needed. Preconception control, early antenatal booking and good control in pregnancy are strongly advocated as means of achieving good pregnancy outcome.
  • Thumbnail Image
    Item
    Serum testosterone and lipids in relation to sexual dysfunction in males with metabolic syndrome and type 2 diabetes mellitus
    (Academic Journals, 2010-12) Umoh, U.; Charles-Davies, M. A.; Adeleye, J.
    Low serum testosterone is associated with insulin resistance, metabolic syndrome (case 1), type 2 diabetes mellitus (case 2), and cardiovascular disease. This study aims at identifying possible alterations in circulating testosterone and their relationship with plasma lipids in case1 and case2. Ninety-two male subjects were recruited in this prospective, cross-sectional study from two major hospitals in Ibadan and environs, Nigeria. Demographic, sexual and anthropometric characteristics were obtained from questionnaires by use of standard methods. Blood samples (10 ml) were obtained for determination of glucose, total cholesterol, triglycerides and high density lipoprotein by enzymatic methods while low density lipoprotein was calculated. Testosterone was analysed by Enzyme Immunoassay (Fortress Diagnostics, UK.). SPSS software version 16.0 was used for statistical analysis to find associations and relationships. Significantly lower concentrations of testosterone and high density lipoprotein, but higher concentrations of glucose in case 1 and 2 groups were observed compared with controls (p<0.05). Testosterone correlated positively with libido and nocturnal/early morning erection but inversely with erectile dysfunction only in case 2 (p<0.05). Deficient glucose uptake by the pituitary and the gonads and low circulating high density lipoprotein, consequence of insulin resistance could lead to hypogonadism. Dietary modulation and exercise may therefore be beneficial.