Browsing by Author "Adenipekun, A."

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Correlates of depression and anxiety among the cancer patients in the radiotherapy clinic in UCH, Ibadan, Nigeria
(2015) Asuzu, C. C.; Adenipekun, A.
The diagnosis of cancer and its management result in several problems for cancer patients. This may result from factors some of which may be modifiable. This study was aimed at identifying the prevalence of depression and anxiety in patients attending the Radiotherapy Clinic in the UCH, Ibadan and to identify the variables affecting them. The Beck’s Depression Inventory (BDI-II) and the Fear of Progression (FOP12) scales were used to assess depression and anxiety among cancer patients. The 206 diagnosed cancer patients studied were made up of 146 (79.6%) women and 42 (20.4%) men. Some 76 (36.9%) had moderate to very high anxiety while 29 (14.1%) had borderline to severe depression. The ages ranged between 10 to 85 years with a mean of 47.84 (+/_ 16.45). In prevalence of anxiety and depression, 36.9% of the cancer patients experience varying levels of anxiety and 31.6% experience varying levels of depression. On logistic regression, age, religion, educational level and treatment type significant factors for anxiety. Specifically, being older than 40years, being a Christian, not reporting educational qualification and not yet commencing treatment compared to having surgery as the current treatment type was significant risk factors for anxiety. Only treatment type was a significant risk factor for depression that is not yet commencing treatment compared to having surgery as the current treatment type was a factor for depression. Appropriate Psychological evaluation and therapy as may be needed should be administered to all oncology patients preparing for surgery and chemotherapy to enhance their emotional and psychological wellbeing. The findings of this study have implication for establishment of psycho-oncology care in all the cancer centres in Nigeria.
Knowledge and attitudes of terminally ill patients and their family to palliative care and hospice services in Nigeria
(2005-06) Adenipekun, A.; Onibokun, A.; Elumelu, T. N.; Soyannwo, O. A.
Bacground: A palliative care and Hospice service is a neglected aspect of medical discipline especially in a developing country like Nigeria. With the global increase in incidence of cancer and HIV/A IDS and 70% of them presenting late, coupled with limited resources, for effective symptom control, palliative care therefore remains the only option left to improve the quality of life of the patients. Objective: To assess the, knowledge and attitudes of patients and their relations to palliative care and hospice services {PC&H} and to fashion out appropriate services for the patients. Materials and methods: A total of 130 participants were studied using a questionnaire which comprised of three parts: Socio-demographic variables. Information about Knowledge and Attitudes towards PC&H. Results: Sixty nine were patients while 61 were family members. Ninety four [72.3%] had no knowledge of PC&H regardless of level of education and social status. 109 (84%) agreed that symptoms of the terminally ill patients should be treated to improve their quality of life and 75%. of the participants agreed that this will be better done in a Hospice. 106 183% | participants desire to have hospice established in every community, this again was regardless of tribe Conclusion: There is a gross lack of knowledge about PC&H in our community as evidenced among, the participants studied. However, there is a positive attitude towards PC&H suggesting a general acceptance, since there is presently no well established Hospice, in Nigeria; we recommend that government and Non-governmental organizations should assist in this area. A hospital based Hospice might be a starting point
Radiation nephritis: anti-inflammatory effect of dexamethasone in adult wistar rats (rattus norvegicus)
(Sociedad Chilena de Anatomía, Temuco, Chile, 2008) Owoeye, O.; Malomo, A. O.; Elumelu, T. N.; Salami, A. A.; Osuagwu, F. C.; Akinlolu, A. A.; Adenipekun, A.; Shokunbi, M. T.
"The anti-inflammatory effect of dexamethasone on the irradiated kidneys of adult Wistar rats (Rattus norvegicus) was studied. Eighteen adult Wistar rats were, after acclimatization, randomly divided into 3 groups of 6 animals per group. The control group had normal saline, receiving neither drugs nor radiation. The second group received normal saline and radiation. The third group received pretreatment with dexamethasone at 1mg/kg body weight/day for 2 days followed by radiation. Radiation was delivered to the animals as a single fraction of 2.5 Gy of gamma rays from Cobalt-60 source, using an AECL Theatron 780-C Teletherapy machine. After exposure to the different interventions, the animals were sacrificed on the 14th post-irradiation day and the kidneys dissected out from each animal. The renal tissues were subjected to histological processing, and then studied using an eyepiece objective ruler calibrated with a 2mm stage micrometer for histomorphometric studies. The result of the study showed that all irradiated animals suffered weight loss by the 14th day post-irradiation (p<0.05) irrespective of the additional treatment with dexamethasone and this was statistically significant. Histomorphometry showed that the maximum width of the glomerular capsule was significantly greater in the radiation groups than in the control at p<0.05. The maximal glomerular diameter was significantly greater in irradiated animals compared with the control animals at p<0.05. The outcome of this study showed that the intraperitoneal administration of dexamethasone at 1mg/kg body weight/day for 2 days prior to treatment with irradiation did not prevent weight loss nor ameliorate the swelling of the nephrons resulting from the effect of radiation injury to the Wistar rat."