Browsing by Author "Alonge, T. O."

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A descriptive study of the morbidity pattern of older persons presenting at a geriatric centre in southwestern Nigeria.
(Wolters Kluwer - Medknow Publications, 2017) Cadmus, E. O.; Adebusoye, L. A.; Olowookere, O. O.; Oluwatosin, O. G.; Owoaje, E. T.; Alonge, T. O.
Context: Rapid population ageing is a demographic reality in most countries of the world. Old age is associated with changes which may culminate in health problems, necessitating provision of appropriate preventive, curative, and rehabilitative services. However, reports from many low- and middle-income countries have shown lack of preparedness to cater for the healthcare needs of older persons. Aim: This study described the morbidity profile and its determinants among persons aged 60 years and above who presented at an established geriatric centre in southwestern Nigeria. Materials and Methods: Data were obtained from electronic health records of 4886 patients aged ≥60 years who visited the facility between 1st January 2013 and 31st December 2014. Data were analyzed using Stata version 13 (Texas, USA). Frequency distributions were used for descriptive analysis, and chi-square test was used to test associations. Results: More than a half, 2919 (59.7%), of the respondents were females and almost three quarters 3501 (71.7%) were aged between 60 and 74 years. Mean number of morbidities was 1.81 ± 0.9, and less than half, 1097 (42.0%), presented with only one morbidity, most commonly, hypertension. There were significant age-related differences for musculoskeletal (P = 0.001), endocrine (P = 0.01), and psychological problems (P = 0.01). In addition, gender differences were observed as a significantly higher proportion of females presented with general symptoms (P = 0.02) and musculoskeletal problems (P = 0.0001) than men. Conclusion: The most common presenting morbidities at this geriatric health centre were mostly no communicable diseases. Information obtained will be useful in the design of similar facilities in other parts of the country and region at large.
Association of the ABO blood group with SARS-CoV-2 infection in a community with low infection rate
(International Society of Blood Transfusion, 2021) Kotila, T. R.; Alonge, T. O.; Fowotade, A.; Famuyiwa, O. I.; Akinbile, A. S.
Background and objectives Reports on the association of the ABO phenotypes with infection by the SARS-CoV-2 virus have mostly come from countries with high infection rates. This study examined the possible association between SARS-CoV-2 infection and the ABO phenotype in Black Africa. Materials and methods This report is from a single centre where both asymptomatic and symptomatic patients were quarantined. At the time of this report, Oyo State, Nigeria had carried out 15 733 tests of which 3119 were positive for the virus with 1952 recoveries and 37 deaths. The ABO distribution of patients was compared with that of a blood donor population. Results Of the 302 participants, 297 (98%) had their blood group determined, asymptomatic and symptomatic individuals were 123 (40_7%) and 179 (59_3%) respectively. Blood group O was significantly less represented among the patients (P < 0_01) while blood groups B and AB were significantly more represented (P < 0_01, P = 0_03 respectively). Patients with anti-B (groups A and O) were significantly less represented than those without anti-B (B and/or AB): B and AB (P < 0_001), B (P = 0_002), AB (P = 0_01). There was no difference in the blood group distribution of symptomatic and asymptomatic patients (v2 (3, N = 302) = 2_29; P = 0_51), but symptomatic patients with anti-A (groups B and O) were more represented than asymptomatic patients with anti-A (v2 4_89; P = 0_03). Conclusion The higher prevalence of blood group O and more potent beta haemolysins (anti-B antibodies) are likely reasons for the lower infectivity by the SARS-CoV-2 virus and severity of COVID-19 disease in the community.
Blueprint for health security in Nigeria by 2050: Ageing and ageing- related diseases
(University of Ibadan, Nigeria, 2019) Akinyemi, R. O.; Cadmus, E. O.; Adeniji, O.; Ajayi, S.; Farombi, T.; Omobowale, O. C.; Olowookere, O. O.; Adebusoye, L. A.; Alonge, T. O.; Ogunniyi, A
Background: Nigeria is currently populated by about 200 million people of diverse ethnic, cultural and religious inclinations. Projections estimate that the proportion and absolute number of older persons aged 60 years and above (currently about 5% of the total population) will increase to 25 million by the year 2050. Ageing of the Nigerian population has far reaching multifaceted economic, psychosocial, educational and health implications. Situation analysis: In this paper, a scenario-based analysis is presented on the likely trajectory of health security for older Nigerians by the year 2050. Ageing – associated diseases are predominantly non - communicable (NCD) and their burden is likely to increase over the next 30 years. The combined burden of NCDs and infectious diseases (malaria, tuberculosis, HIV/AIDS, emerging and re – emerging diseases) suggest that the demand on health services (preventive, diagnostic, curative, rehabilitative and palliative care) from older persons and the elderly will increase in tandem with the growth of this segment of the population. Conclusion: A blueprint for achieving healthy ageing for older persons by the year 2050 is presented. This encompasses set targets, strategic plans and a monitoring and evaluation scheme. Improved funding and coverage of the National Health Insurance Scheme, better pensions and retirement benefit coverage, other social schemes and policy interventions and rigorous implementation schemes are all required for achieving health security by the year 2050 with respect to ageing and ageing – related disorders.
Challenges of conducting research in developing countries
(The Postgraduate School, University of Ibadan, Ibadan, 2006) Ekhaguere, G. O. S.; Olayinka, A. I.; Taiwo, V. O.; Alonge, T. O.; Obono, O. M.
Geograpic information systems in determining road traffic crash analysis in Ibadan, Nigeria
(2014-09) Rukewe, A.; Taiwo, O. J.; Fatiregun, A. A.; Afuwape, O. O.; Alonge, T. O.
Background: Road traffic accidents are frequent in this environment, hence the need to determine the place of geographic information systems in the documentation of road traffic accidents. Aim & Objectives: To investigate and document the variations in crash frequencies by types and across different road types in Ibadan, Nigeria. Materials & Methods: Road traffic accident data between January and June 2011 were obtained from the University College Hospital Emergency Department's trauma registry. All the traffic accidents were categorized into motor vehicular, motorbike and pedestrian crashes. Georeferencing of accident locations mentioned by patients was done using a combination of Google Earth and ArcGIS software. Nearest neighbor statistic, Moran's-I, Getis-Ord statistics, Student T-test, and ANOVA were used in investigating the spatial dynamics in crashes. Results: Out of 600 locations recorded, 492 (82.0%) locations were correctly georeferenced. Crashes were clustered in space with motorbike crashes showing greatest clustering. There was significant difference in crashes between dual and non-dual carriage roads (P = 0.0001), but none between the inner city and the periphery (p = 0.115). However, significant variations also exist among the three categories analyzed (p = 0.004) and across the eleven Local Government Areas (P = 0.017). Conclusion: This study showed that the use of Geographic Information System can help in understanding variations in road traffic accident occurrence, while at the same time identifying locations and neighborhoods with unusually higher accidents frequency.
Haemocytometric profile of Nigerian patients with Covid-19
(Faculty of Basic Mdical Sciences, University of Ibadan, 2021) Arinola, O. G.; Edem V. F.; Rahamon, S. K.; Fowotade, A.; Onifade, A. A.; Adekanmbi, O. B.; Salami, O. I.; Fashina, O. A.; Ishola, O. C.; Akinbola, I. O.; Akinbile, A. S.; Eegunjobi, O. A.; Bello, M. D.; Famuyiwa, O. I.; Olaoti, A. J.; Olaniyan, O. A.; Oke, C. A.; Johnson, O. J.; Fagbemi, S. O.; Alonge, T. O.
The haemocytometric changes and possible interplay with duration of hospital stay, gender and age in Nigerians with COVID-19 were determined in this study. Routine haemocytometry was evaluated using a standard method and thereafter, neutrophil-lymphocyte ratio (NLR); a marker of inflammation was calculated. Neutrophil percentage, total white blood cell (WBC) count and NLR were significantly higher while lymphocyte percentage was significantly lower in patients with COVID-19 compared with the controls. In females with COVID-19, neutrophil percentage was significantly higher compared with the males. Considering length of hospital stay, monocyte percentage was significantly higher in patients who spent more than 10 days on admission compared with those with 10 or fewer days of admission. At discharge, the proportion of patients with monocyte percentage above the reference range was significantly lower compared with baseline. Also, monocyte percentage in COVID-19 patients had significant positive correlation with days on admission. Alteration in haemocytometry worsens with increasing age as percentages of monocyte and neutrophil, NLR and WBC count were significantly higher while the lymphocyte percentage was significantly lower in patients aged 40 years and above compared with younger patients. Also, age had significant positive correlation with percentages of monocyte and neutrophil, NLR and WBC count but a significant negative correlation with lymphocyte percentage. Haemocytometric changes and inflammation in COVID-19 patients increase with age. Also, monocyte count could be an indicator of longer hospital stay and its reduction might be an indicator of recovery from the disease.
Malaria and COVID-19 co-infection: a symptom diagnostic challenge in a malaria endemic setting
(Verduci International, 2021) Fowotade, A.; Bamidele, F. R.; Adekanmbi, O.; Fasina, O. N.; Famuyiwa, O.; Alonge, T. O.
Objective: To determine the prevalence and risk factors for malaria and COVID-19 co-infection. Patients and methods: A total of 135 COVID-19 positive patients were consecutively recruited from the Infectious Diseases Hospital, Olodo, Ibadan, Oyo State. Nasopharyngeal and oropharyngeal swab samples were obtained during hospitalization and tested by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) using the BGI SARS-Cov-2 kit (China). Blood was also obtained by needle prick and malaria tests were performed using the SD BIOLINE Malaria Ag P.f/Pan test. Risk factors were entered into individual case investigation forms. Results: Malaria and COVID-19 co-infection rate was 7%. The predominant clinical manifestation was fever (28.1%) and the study showed that COVID-19 and malaria co-infection was associated with increased odds of fever compared to COVID-19 mono-infection (p-value=0.415, OR=4.960). Significant risk factors for malaria/COVID-19 are age of participants (p= 0.000) and CT values for by SARS-Cov2 RTPCR (p=0.013). Fever is a common symptom in either malaria or COVID-19 infection thus posing a diagnostic challenge. Proper risk assessment of febrile patients and laboratory evaluation for COVID-19 and/ or malaria is a prerequisite for appropriate distinction.
Prevalenc of abnormal bone minieral density in HIV-positive patients in Ibadan, Nigeria
(West African College of Surgeons, 2013) Alonge, T. O.; Okoje-Adesomoju, V. N.; Atalabi, O. M.; Obamuyide, H. A.; Olaleye, D.; Adewole, I. F.
Background:There have been reports of high rate of abnormal bone mineral densities (BMD) among people living with HIV. Following the introduction of combination antiretroviral therapy (CART) into Nigeria, the country is now home to increasing population of HIV positive patients. There is paucity of data about osteoporosis/osteopaenia and bone mineral density in this population. Aim and Objectives: The aim of the study was to determine the prevalence and determinants of osteopaenia/osteoporosis in a cohort of HIV-positive patients in Nigeria. Patients and methods: The BMD of a group of patients attending the outpatient clinic of the University of Ibadan, Nigeria was assessed using a DXA machine. The relationship of bone mineral density to body weight, CART status, protease inhibitor use, and gender was investigated. Their CD4 counts and viral load were also estimated. Result: A total of 1005 patients participated with a mean age of 41.3 ± 10 years. There were 724 females (72.0%) and 29.7% were single. The median length of diagnosis was 2 years (Range 1-18 years). The Median CD4 count was 371cells/ml and Median viral load was 200 copies/ml. Of this sample, 785 (78.1%) were on CART with 99 (12.6%) on protease inhibitor. The mean body mass index (BMI) was 23.7±4.7 with 9.2% underweight and 10% obese. The prevalence of osteopaenia and osteoporosis were 46.6% and 31.9% respectively, while 19.6% had normal bone mineral density (BMD). Osteoporosis was significantly higher in those aged above 40 years (p= 0.00001), the females (p= 0.022), the single (p=0.028) and the underweight (p=0.0001). There was no significant difference in BMD of those with or without protease inhibitor containing medications as well as treatment naïve patients. Conclusion: A high prevalence of abnormal bone mineral density was found in HIV positive patients in Nigeria. Patient age above 40 years and a body mass index class of underweight were significant associated factors. Routine bone mineral density assessment is recommended as an adjunct in the evaluation of HIV positive patients in Nigeria.
Prevalence of abnormal bone mineral density in HIV_postive patients in Ibadan, Nigeria
(2013) Alonge, T. O.; Okoje-Adesomoju, V. N.; Atalabi, O. M.; Obamuyide, H. A.; Adewole, I. F.
"Background:There have been reports of high rate of abnormal bone mineral densities (BMD) among people living with HIV. Following the introduction of combination antiretroviral therapy (CART) into Nigeria, the country is now home to increasing population of HIV positive patients. There is paucity of data about osteoporosis/osteopaenia and bone mineral density in this population. Aim and objectives:The aim of the study was to determine the prevalence and determinants of osteopaenia/osteoporosis in a cohort of HIV-positive patients in Nigeria. Patients and methods:The BMD of a group of patients attending the outpatient clinic of the University of Ibadan, Nigeria was assessed using a DXA machine. The relationship of bone mineral density to body weight, CART status, protease inhibitor use, and gender was investigated. Their CD4 counts and viral load were also estimated. RESULTS:A total of 1005 patients participated with a mean age of 41.3 ± 10 years. There were 724 females (72.0%) and 29.7% were single. The median length of diagnosis was 2 years (Range 1-18 years). The Median CD4 count was 371cells/ml and Median viral load was 200 copies/ml. Of this sample, 785 (78.1%) were on CART with 99 (12.6%) on protease inhibitor. The mean body mass index (BMI) was 23.7±4.7 with 9.2% underweight and 10% obese. The prevalence of osteopaenia and osteoporosis were 46.6% and 31.9% respectively, while 19.6% had normal bone mineral density (BMD). Osteoporosis was significantly higher in those aged above 40 years (p= 0.00001), the females (p= 0.022), the single (p=0.028) and the underweight (p=0.0001). There was no significant difference in BMD of those with or without protease inhibitor containing medications as well as treatment naïve patients.CONCLUSION:A high prevalence of abnormal bone mineral density was found in HIV positive patients in Nigeria. Patient age above 40 years and a body mass index class of underweight were significant associated factors. Routine bone mineral density assessment is recommended as an adjunct in the evaluation of HIV positive patients in Nigeria."
Serological profile of convalescent COVID-19 patients at an infectious diseases hospital in Nigeria
(Sciencedomain International, 2021) Fowotade, A.; Fasuyi, T. O.; Omoruyi,E. C.; Alonge, T. O.
Background: IgG antibodies may serve as promising targets to detect and evaluate immune responses against the SARS-CoV-2 virus. Both IgA and IgM antibodies target the spike protein’s receptor binding domain and are rapidly decayed, while IgG antibodies remain relatively stable for longer periods in COVID-19 patients. Objectives: The current study was designed to detect the presence of SARS-CoV-2 antibodies among convalescent COVID-19 patients and to evaluate the relationship between these antibodies, the symptom grade and their baseline Cycle Threshold (CT) by RT-PCR. Methods: Eighty-nine convalescent COVID-19 patients on admission were recruited and tested until negative by RT-PCR. Sera obtained from participants were screened for SARS-CoV-2 IgM and IgG antibodies using rapid lateral flow assays. Results: It was observed that 93,3% and 77,5% respectively had IgM and IgG antibodies against the S1 protein of SARS-CoV-2. Majority (74,0%) presented with mild COVID-19 symptoms with a mean RT-PCR Ct value of 31,4. Conclusion: Convalescent COVID-19 patients develop a fairly good level of IgG antibodies. Theantibody status is not dependent on CT value or symptom grade. However, there was a significant correlation between baseline CT and time taken to test negative by RT-PCR.