Browsing by Author "Bakare, R."

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    Recent Rubella infection among childbearing women in a tertiary hospital in Nigeria: a Seroepidemiological indication for vaccination need
    (African Society for Clinical and Experimental Microbiology, 2016) Suleiman, S. T.; Bakare, R.; Akanbi, A. A.; Fowotade, A.; Billiaminu, S. A.; Durowade, K. A.
    Background: Congenital Rubella Infection can be prevented and future generation saved from disability by protecting women of reproductive age through vaccination. The study is aimed at determining serological evidence of recent rubella infection among women of childbearing age. Method: A cross sectional study was carried out among 285 women aged between 15 and 49 years. Enzyme immunoassay method was used to detect and quantify human IgM and IgG antibodies with avidity for Rubella virus in sera of participants. Socio-demographic characteristics of the subjects, along with recent history of fever, rash and adverse pregnancy outcome among others were obtained using a questionnaire. Statistical analysis was carried out using the program statistical package for social sciences (SPSS) version 16. Majority (78.3%) of the women recruited for the study were within 15-34 years age range. Of the 285 sera assayed for Rubella IgM antibodies, 23 (8.1%; 95% CI: 4.9%-11.3 %.) was IgM seropositive, while the remaining 262 (91.9%) were seronegative. A total of 7 (2.5%) of reproductive age women in Ilorin had a recent primary infection while 16 (5.6%) had a persistent Rubella infection or recent re-infection. In conclusion, there is need for vaccination of susceptible women of reproductive age in Ilorin as a large number of women have Rubella in their reproductive age.
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    Rubella antibody avidity among rubella seropositive women attending a tertiary care facility in Nigeria
    (Aras Part Medical International Press, 2015) Suleiman, S. T.; Bakare, R.; Akanbi II, A. A.; Fowotade, A.; Billiaminu, S. A.; Durowade, K. A.
    Objectives: The aim of this study was to determine the seroprevalence of rubella virus antibodies among women of reproductive age group and assess risk factors of rubella infection. Materials and Methods: A cross-sectional study was carried out among 285 women aged between 15 and 49 years. Enzyme-linked immunosorbent assay (ELISA) method was used to detect and quantify human immunoglobulin G (IgG) antibodies with avidity for rubella virus in sera of participants. Socio-demographic characteristics of the participants, along with recent and previous history of fever and rash among others were obtained using a questionnaire. Statistical analysis was carried out using SPSS version 16. Results: Seroprevalence of rubella IgG among women of reproductive age in Ilorin was 92.3% (95% CI: 89.2%-95.4%). Thus susceptibility rate to rubella infection was 7.7%. Majority (87.1%) of the IgG seropositive participants had high rubella IgG avidity, implying past rubella infection or reinfections. Seroprevalence was significantly higher among participants from lower educational and socio-economic classes compared with other participants (P = .035 and P = .023, respectively). There was a negative correlation between age and rubella specific IgG titer (P = .000). Thus rubella specific IgG titer decreases with increasing age. Conclusion: There is need for vaccination of susceptible women of reproductive age in Ilorin as the rubella susceptibility rate was higher than the 5.0% target set by the World Health Organization (WHO) for prevention of congenital rubella syndrome (CRS).