Browsing by Author "Falade, A. G."

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Bilateral congenital cystic adenomatiod malformation of the lungs: a case report
(2006) Atalabi, O. M; Ogunseyinde, A. O.; Obajimi, M. O.; Falade, A. G.; Adebo, A. O.; Jite, I. E.
A six weeks old infant presented with scalp ulcer and fever, and on examination was found to have resonant percussion notes bilaterally. The initial chest radiograph revealed multiple lucencies which were initially thought to be due to diaphragmatic hernia, but the dilemma was resolved by Computerized tomography which revealed the lucencies to be multiple cysts characteristics of Congenital Cystic Aaenomatiod Malformation (CCAM) type II.
Bilateral orbital rhabdomyosarcoma mimicking burkitt's lymphoma
(1998) Falade, A. G.; Osinusi, K.; Baiyeroju-Agbeja, A. M.; Ogunbiyi, J. o.; Owoeye, J. F. A.; Thomas, J
Bilaterial orbital rhabdomyosarcoma mimicking Burkitt's lymphoma in an 11-year old girl is reported. The patient presented with bilateral proptosis and right cervical lymphadenopathy. Despite consultations at a number of hospitals, a definitive diagnosis was not made until presentation at the University College Hospital, Ibadan, where cytological examination of a fine needle aspiration biopsy specimen of the tumour and the lymph node revealed. changes that were consistent with those seen in rhabdomyosarcoma. This case emphasises the fact that rhabdomyosarcoma is an important differential diagnosis of orbital tumours in childhood, especially in Burkitt's lymphoma endemic areas.
Care seeking for under-five children and vaccine perceptions during the first two waves of the COVID-19 pandemic in Lagos State, Nigeria: a qualitative exploratory study
(BMJ Publishing Group Ltd, 2023) Bakare, A. A.; Olojede, O. E.; King, C.; Graham, H.; Uchendu, O.; Colbourn, T.; Falade, A. G.; Alvesson, H. M.
Objective To explore healthcare seeking practices for children and the context-specific direct and indirect effects of public health interventions during the first two waves of COVID-19 in Lagos State, Nigeria. We also explored decision-making around vaccine acceptance at the start of COVID-19 vaccine roll-out in Nigeria. Design, setting and participants A qualitative explorative study involving 19 semistructured interviews with healthcare providers from public and private primary health facilities and 32 interviews with caregivers of under-five children in Lagos from December 2020 to March 2021. Participants were purposively selected from healthcare facilities to include community health workers, nurses and doctors, and interviews were conducted in quiet locations at facilities. A data-driven reflexive thematic analysis according to Braun and Clark was conducted. Findings Two themes were developed: appropriating COVID-19 in belief systems, and ambiguity about COVID-19 preventive measures. The interpretation of COVID-19 ranged from fearful to considering it as a ‘scam’ or ‘falsification from the government’. Underlying distrust in government fuelled COVID-19 misperceptions. Care seeking for children under five was affected, as facilities were seen as contagious places for COVID-19. Caregivers resorted to alternative care and self-management of childhood illnesses. COVID-19 vaccine hesitancy was a major concern among healthcare providers compared with community members at the time of vaccine roll-out in Lagos, Nigeria. Indirect impacts of COVID-19 lockdown included diminished household income, worsening food insecurity, mental health challenges for caregivers and reduced clinic visits for immunisation. Conclusion The first wave of the COVID-19 pandemic in Lagos was associated with reductions in care seeking for children, clinic attendance for childhood immunizations and household income. Strengthening health and social support systems with context-specific interventions and correcting misinformation is crucial to building adaptive capacity for response to future pandemics.
Integrated sustainable childhood Pneumonia and infectious disease reduction in Nigeria (INSPIRING) through whole system strengthening in Jigawa, Nigeria: study protocol for a cluster randomised controlled trial
(BioMed Central Ltd, 2022) King, C.; Burgess, R. A.; Bakare, A. A.; Shittu, F.; Salako, J.; Bakare, D.; Uchendu, O. C.; Iuliano, A.; Isah, A.; Adams, O.; Haruna, I.; Magama, A.; Ahmed, T.; Ahmar, S.; Cassar, C.; Valentine, P.; Olowookere, T. F.; MacCalla, M.; Graham, H. R.; McCollum, E. D.; Falade, A. G.; Colbourn, T.
Background: Child mortality remains unacceptably high, with Northern Nigeria reporting some of the highest rates globally (e.g. 192/1000 live births in Jigawa State). Coverage of key protect and prevent interventions, such as vaccination and clean cooking fuel use, is low. Additionally, knowledge, care-seeking and health system factors are poor. Therefore, a whole systems approach is needed for sustainable reductions in child mortality. Methods: This is a cluster randomised controlled trial, with integrated process and economic evaluations, conducted from January 2021 to September 2022. The trial will be conducted in Kiyawa Local Government Area, Jigawa State, Nigeria, with an estimated population of 230,000. Clusters are defined as primary government health facility catchment areas (n = 33). The 33 clusters will be randomly allocated (1:1) in a public ceremony, and 32 clusters included in the impact evaluation. The trial will evaluate a locally adapted ‘whole systems strengthening’ package of three evidence-based methods: community men’s and women’s groups, Partnership Defined Quality Scorecard and healthcare worker training, mentorship and provision of basic essential equipment and commodities. The primary outcome is mortality of children aged 7 days to 59 months. Mortality will be recorded prospectively using a cohort design, and secondary outcomes measured through baseline and endline cross-sectional surveys. Assuming the following, we will have a minimum detectable effect size of 30%: (a) baseline mortality of 100 per 1000 livebirths, (b) 4480 compounds with 3 eligible children per compound, (c) 80% power, (d) 5% significance, (e) intra-cluster correlation of 0.007 and (f) coefficient of variance of cluster size of 0.74. Analysis will be by intention-totreat, comparing intervention and control clusters, adjusting for compound and trial clustering. Discussion: This study will provide robust evidence of the effectiveness and cost-effectiveness of community-based participatory learning and action, with integrated health system strengthening and accountability mechanisms, to reduce child mortality. The ethnographic process evaluation will allow for a rich understanding of how the intervention works in this context. However, we encountered a key challenge in calculating the sample size, given the lack of timely and reliable mortality data and the uncertain impacts of the COVID-19 pandemic.
Measuring oxygen access: lessons from health facility assessments in Lagos, Nigeria
(BMJ Publishing Group Ltd, 2021) Graham, H. R.; Olojede, O. E.; Bakare, A. A.; Iuliano, A.; Olatunde, O.; Isah, A.; Osebi, A.; Ahmed, T.; Uchendu, O. C.; Burgess, R.; McCollum, E.; Colbourn, T.; King, C.; Falade, A. G.
The COVID-19 pandemic has highlighted global oxygen system deficiencies and revealed gaps in how we understand and measure ‘oxygen access’. We present a case study on oxygen access from 58 health facilities in Lagos state, Nigeria. We found large differences in oxygen access between facilities (primary vs secondary, government vs private) and describe three key domains to consider when measuring oxygen access: availability, cost, use. Of 58 facilities surveyed, 8 (14%) of facilities had a functional pulse oximeter. Oximeters (N=27) were typically located in outpatient clinics (12/27, 44%), paediatric ward (6/27, 22%) or operating theatre (4/27, 15%). 34/58 (59%) facilities had a functional source of oxygen available on the day of inspection, of which 31 (91%) facilities had it available in a single ward area, typically the operating theatre or maternity ward. Oxygen services were free to patients at primary health centres, when available, but expensive in hospitals and private facilities, with the median cost for 2 days oxygen 13 000 (US$36) and 27 500 (US$77) Naira, respectively. We obtained limited data on the cost of oxygen services to facilities. Pulse oximetry use was low in secondary care facilities (32%, 21/65 patients had SpO2 documented) and negligible in private facilities (2%, 3/177) and primary health centres (<1%, 2/608). We were unable to determine the proportion of hypoxaemic patients who received oxygen therapy with available data. However, triangulation of existing data suggested that no facilities were equipped to meet minimum oxygen demands. We highlight the importance of a multifaceted approach to measuring oxygen access that assesses access at the point-of- care and ideally at the patient-level. We propose standard metrics to report oxygen access and describe how these can be integrated into routine health information systems and existing health facility assessment tools.
Prevalence of pneumonia and malnutrition among children in Jigawa state, Nigeria: a community-based clinical screening study
(BMJ Publishing Group Ltd, 2022) King, C.; Siddle, M.; Adams, O.; Ahmar, S.; Ahmed, T.; Bakare, A. A.; Bakare, D.; Burgess, R. A.; Colbourn, T.; McCollum, E. D.; Olowookere, T.; Salako, J.; Uchendu, O.; Graham, H. R.; Falade, A. G.
Objective To estimate the point prevalence of pneumonia and malnutrition and explore associations with household socioeconomic factors. Design Community-based cross-sectional study conducted in January–June 2021 among a random sample of households across all villages in the study area. Setting Kiyawa Local Government Area, Jigawa state, Nigeria. Participants Children aged 0–59 months who were permanent residents in Kiyawa and present at home at the time of the survey. Main outcome measures Pneumonia (non-severe and severe) defined using WHO criteria (2014 revision) in children aged 0–59 months. Malnutrition (moderate and severe) defined using mid-upper arm circumference in children aged 6–59 months. Results 9171 children were assessed, with a mean age of 24.8 months (SD=15.8); 48.7% were girls. Overall pneumonia (severe or non-severe) point prevalence was 1.3% (n=121/9171); 0.6% (n=55/9171) had severe pneumonia. Using an alternate definition that did not rely on caregiver-reported cough/difficult breathing revealed higher pneumonia prevalence (n=258, 2.8%, 0.6% severe, 2.2% non-severe). Access to any toilet facility was associated with lower odds of pneumonia (aOR: 0.56; 95% CI: 0.31 to 1.01). The prevalence of malnutrition (moderate or severe) was 15.6% (n=1239/7954) with 4.1% (n=329/7954) were severely malnourished. Being older (aOR: 0.22; 95% CI: 0.17 to 0.27), male (aOR: 0.77; 95% CI: 0.66 to 0.91) and having head of compound a business owner or professional (vs subsistence farmer, aOR 0.71; 95% CI: 0.56 to 0.90) were associated with lower odds of malnutrition. Conclusions In this large, representative community-based survey, there was a considerable pneumonia and malnutrition morbidity burden. We noted challenges in the diagnosis of Integrated Management of Childhood Illness-defined pneumonia in this context.
An unusual presentation of congenital bronchoesophageal fistula
(2004-01-03) Atalabi, O. M; Falade, A. G.; Obajimi, O. M.; Akinyinka, O. O.; Lagundoye, S. B.; Ibinaiye, P. O.
We present the case of a 5-week-old neonate with multiple congenital abonormalities including a broncho-oesophageal fistula, which showed radiological features suggestive of congenital diaphragmatic hernia. Emergency limited barium swallow done was initially reported as a case of diapragmatic hernia. Autopsy revealed pus within the right lung, and a fistulous connection between the oesophagus and an intra-abdominal organ abnormality were seen, and an occipital meningomyelocoele was also confirmed.