Browsing by Author "Folasire, O. F."

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Anti-hyperglycemic effect of cocoyam (Xanthosoma sagittifollium) corm in alloxan-induced diabetic albino rats
(Academic Journals, 2016) Folasire, O. F.; Oridupa, O. A.; Owolabi, A. J.; Adepoju, O. T.
Diabetes mellitus constitutes a global public health concern and dietary approach is key to the control and prevention of lethal complications. This study investigated the hypoglycemic and anti-hyperglycemic effects of Xanthosoma sagittifolium-incorporated diets in normoglycemic and alloxan induced diabetic rats. Seventy normoglycemic male Wistar strain albino rats (120 to 200 g) were divided into two groups of thirty-five each. Group 1 was randomly distributed into seven subgroups and each subgroup assigned to 100% rat pellets, X. sagittifolium-incorporated rat pellet (25, 50 and 75%), 100% X. sagittifolium, 100% X. sagittifolium + Glibenclamide (oral hypoglycaemic agent for treatment of diabetes) or 100% rat pellets + Glibenclamide. Diabetes was induced in Group 2 rats fasted for 12 h by intraperitoneal injection of Alloxan (100 mg/kg body weight). Initial fasting blood glucose levels (BGL) were recorded, and alloxan-treated rats with BGL >200 mg/dl 48 h post-induction were considered diabetic and divided into seven subgroups. Dietary treatment was carried out, and blood glucose level (BGL) monitored for 14 days. Data obtained were analyzed using one way analysis of variance (ANOVA) and Tukey’s post-hoc test at p< 0.05. X. sagittifolium caused a significant reduction in the BGL of alloxan-induced diabetic rats (p0.05) but no hypoglycemic effect in normoglycemic rats. Rats fed 25% (BGL:165.2±16.9 mg/dl), 50% (BGL: 189.2±15.9 mg/dl) and 75% (BGL:152.0±23.0 mg/dl) X. sagittifolium showed better control of BGL by 24 h post-prandial compared with rats administered glibenclamide (BGL: 195.0±18.6 mg/dl) and 100% X. sagittifolium (BGL: 221.0±17.0 mg/dl). Rats fed 75% (BGL: 118.4±11.0 mg/dl) or 100% (BGL: 97.0±17.1 mg/dl) X. sagittifolium had better controlled BGL compared with rats fed pellets and pellets + glibenclamide (BGL: 154.2±19.8 mg/dl) on day 7. X. sagittifolium corm has an antihyperglycemic effect, and its consumption should be encouraged among diabetic patients as a good replacement for other high-calorie diets.
Does nutrition knowledge and practice of athletes translate to enhanced athletic performance? Cross-sectional study amongst Nigerian undergraduate athletes.
(Canadian Center of Science and Education, 2015) Folasire, O. F.; Akomolafe, A. A.; Sanusi, R. A.
Introduction and Objectives: Nutrition knowledge of an athlete, as well as practice, is expected to influence athlete's performance. The study assessed the nutrition knowledge and practice as well as athletes' performance and identified the factors predicting the athletes' performance. Methodology: A cross-sectional survey, involved 110 purposively selected undergraduate athletes (47 females, 63 males) of University of Ibadan, Nigeria, between July 2013 and December 2013. A semi-structured, self-administered questionnaire assessed the nutrition knowledge and practice. 24-hr diet recall and food frequency questionnaire were done. Anthropometric measurements were taken; body composition was determined by bioelectrical impedance analysis method. Handgrip strength (HGS), as an indirect measure of athlete performance, was assessed with the hand dynamometer. Chi-square and t-test analysis were used for the bivariate analysis. Pearson correlation and simple linear regression were used to determine relationships and predict athletic performance. The level of statistical significance was p<0.05 Results: More than half (58.2%) had good nutrition knowledge (NK), and 62.7% had good nutrition practices (NP). Majority (75.4%) had normal handgrip strength (HGS). More than 70.0% frequently do not consume cereals, roots and tubers, fruits and vegetables, legumes /nuts. About 30.0-40.0% frequently do not consume eggs/milk, meat/fish. Having good NK was significantly associated with good NP (χ2 = 15.520, p=0.000), but not with athlete's performance (HGS). There is no significant correlation between NK, NP, and HGS. There is a significant positive correlation between HGS and lean muscle mass (LMM) (r=.670, p=0.000), weight (r=.492, p=0.000), height (r=.521, p=0.000) and energy intake (r=.386, p=0.000). There is a significant negative correlation between HGS and percentage body fat (r=-.400, p=0.000). Athletes’ performance was significantly predicted by the resting metabolic rate (β= .454 C.I=0.011 to 0.045, p=0.003), Lean muscle mass (β =.297 C.I=.059 to 0.562, p=0.024) and the weight (β =.228, C.I=1.852 to .489, p=0.047). Conclusion: Having good nutrition knowledge or practice did not directly determine athletic performance. However, there is the need for nutrition education interventions, to improve athlete’s performance by promoting adequate energy intake, lean muscle mass and appropriate weight gain in athletes.
Effect of traditional treatment of diabetes mellitus with Xanthosoma sagittifolium on the male reproductive system of Alloxan-induced diabetic Wistar rats
(Georg Thieme Verlag KG, 2017) Oridupa, O. A.; Folasire, O. F.; Owolabi, A. J.; Aina, O.
Introduction: The management of diabetes mellitus (DM) targets glycemic control as well as prevention or reversal of other complications associated with the metabolic disorder. One of such complications is the infertility which has been traced to oxidative stress and DNA damage caused by DM. Subjects and methods: In this study, experimentally-induced diabetic male Wistar rats were fed with Xanthosoma sagittifolium (cocoyam) for 14 days and its effect on sperm morphology and characteristics, as well as histology of the testes were assessed. X. sagittifolium corm feed (Xs) were reconstituted with commercial rat feed to contain 25, 50, 75 or 100% X. sagittifolium on a weight/weight basis. Result: One primary and 7 secondary cell abnormalities were observed with overall increased total abnormal sperm cells in the diabetic rats. Sperm cell motility was significantly (p < 0.05) reduced in all diabetic rats, but diabetic rats fed with Xs showed increased motility and liveability. Sperm volume was unchanged, but the depressed sperm count in the untreated diabetic rats was increased in Xs-fed rats. Histology of Xs-fed diabetic rats showed reduction in seminiferous tubule diameter and luminal diameter which was significantly enlarged in untreated diabetic rats. Conclusion: X. sagittifolium significantly (p < 0.05) prevented further deterioration of sperm cell quality and reversed cell apoptosis as presented by increased sperm motility, liveability and count. In the overall, the chances of fertilization by sperm cells from diabetic patients will be increased as well as achievement of good glycemic control and prevention of further damage by the disease condition.
Evaluation of the sub-chronic toxicity profile of the corm of Xanthosoma sagittifolium on hematology and biochemistry of alloxan-induced diabetic Wistar rats
(De Gruyter, 2017) Oridupa O. A.; Folasire, O. F.; Owolabi, A. J.
Background: Hematological and biochemical changes associated with diabetes mellitus and probable reversal were assessed in alloxan-induced diabetic Wistar rats fed with varied percentages of Xanthosoma sagittifolium corm feed (Xs). The changes were compared to normoglycemic rats and diabetic rats treated with glibenclamide. Methods: The study had eight groups in all with group 8 (control) consisting of five normoglycemic rats fed with normal rat pellets (Nrp). Diabetes was experimentally induced by intraperitoneal injection of alloxan to normoglycemic rats. Diabetic rats (serum glucose >200 mg/dL) at 48h postinjection were randomly divided into the seven groups, each diabetic group consisting of five rats. One group was untreated and fed with Nrp, four groups were fed with 25 %, 50 %, 75 % or 100 % Xs, one group was fed with 100 % Xs and administered with glibenclamide, while a 7th group was fed with Nrp and administered with glibenclamide. Results: This study shows that treatment of diabetes with corm of X. sagittifolium increases cellular response to inflammation which is required for body defense against assaulting agents. Decreased serum protein levels observed in untreated diabetic rats were restored in diabetic rats fed with X. sagittifolium corm with particular increase in serum albumin levels but depression of globulin fraction, except in rats fed with X. sagittifolium feed and administered with glibenclamide. X. sagittifolium showed a potent antihyperglycemic effect and corrected the dyslipidemia in a manner comparable to that observed for glibenclamide. Although HDL levels were still low, significant (p <0.05) decrease of LDL levels was a positive indicator of reduced risk for development of cardiovascular and/or coronary heart disease. Conclusions: X. sagittifolium corm can be recommended for inclusion in diets of diabetics without causing further deterioration of health of the diabetic patients.
Feasibility  testing  of  a  designed  food  portion  control  tool  among  diabetic  patients  at  the University  of  Ibadan  health  service  clinic
(Nigeria Diabetes Summit, 2024) Folasire, O. F.; Olagbemide, P. A.
Introduction: Diabetes, a  chronic  disease with  global  prevalence, poses  significant health  risks. Effective  glycaemic control is crucial for preventing complications and managing diabetes with culturally appropriate  dietary education, thus making this study highly relevant. Objectives: To conduct feasibility testing of a designed food portion control tool among diabetic patients at the  University  of  Ibadan  Health  Service  (Jaja  Clinic),   Ibadan.  Feasibility  was  assessed  in  terms  of  the  intervention's reach, acceptability, and practicability. Methods: A mixed study design was used, involving key informant interviews (KII) with nine healthcare  personnel  involved  in  diabetic  management  and  a  cross-sectional  survey  with  purposive  samples  of  41  consenting diabetic patients presenting for routine care at the Jaja Clinic. Patients were exposed to one-on-one dietary education sessions using the food portion control tool in the form of a video recording and a take home handbill of the key intervention messages with re-enforcement SMS delivered weekly for two months.  Feasibility reach was determined by adherence to the intervention messages within a month of the exposure. Acceptability was assessed using a Likert scale questionnaire and generated acceptability score; perceived  practicability was evaluated using KII. Results: Majority had type 2 DM (97.6%) for > 5 years (70.7%). A total of 32 patients were compliant (26 fully  compliant, 6 partially compliant) and 9 defaulters. The intervention reach (78%) was high. Mean acceptability  © score (4.4/5) showed patients rated the food portion control tool  as acceptable. The KII suggested that the  intervention was  practicable. The  facilitators  of implementation were  awareness creation  and education  with continuous reinforcement of Intervention Messages. The predominant barrier was the lack of finance to  procure enough green leafy vegetables/fruits and large portions of staple carbohydrate consumption. Conclusions: implementation  of  the  food  portion  control  tool   was  feasible  in  a  real-life  clinic  setting, emphasising the need for an rct for further testing.
Knowledge, Attitude and Practice of Healthy Lifestyle among Undergraduate Students of the University of Ibadan, Nigeria.
(Nigerian Institute of Food Science and Technology, 2015) Sanusi, R. A.; Ogundero, A.; Folasire, O. F.
Unhealthy lifestyle such as inappropriate diet, lack of exercise, smoking, alcohol consumption, caffeine overuse and improper sleeping habits seen among university students has been associated with the global burden of non-communicable diseases. This study aimed at describing the knowledge, attitude and practice of healthy lifestyle among undergraduates in the University of Ibadan, Nigeria. This descriptive cross-sectional study involved 407 undergraduate students selected from ten undergraduate halls using a simple random sampling technique. A pre-tested, self- administered questionnaire was used to obtain information on socio-demography, knowledge, attitude and practice of healthy lifestyle based on literature. The dietary practice was assessed with a Food Frequency Questionnaire Physical activity was assessed with the short-form of International physical activity Questionnaire (IPAQ) tool. Anthropometric measurements were taken using standard procedures. Data were analyzed using descriptive and inferential statistic at p=0.05. Age of the respondents was 21.8±3.24years and 58% were females. Almost all the respondents (97.8%) had a good knowledge of healthy lifestyle, 38.3% had negative attitude towards healthy lifestyle. About 40% skipped lunch while 7.1% consumed fruits and vegetables daily, as regards the activity level of the respondents, 69%, 12.5%, 10.3% had a moderate, high, and low physical activity levels respectively while 62.4% of the respondents sleep between four and seven hours/day. Majority (71.5%) of the respondents had normal weight while 15.2% were underweight. Even though, majority of the respondents had good knowledge of healthy lifestyle principles, the actual practice was still very low thus highlighting the need for enabling environment to promote adequate practice of healthy lifestyle.
Nutrition evaluation in HIV seropositive patients using the Malnutrition Universal Screening Tool and Subjective Global Assessment in Ibadan, Nigeria
(Nutrition Society of Nigeria, 2015) Folasire, O. F.; Adebayo, A. M.; Sanusi, R.A.
Background: Early identification of nutritional risks in People Living With HIV/AIDS (PLWHA) in low-income settings depends onan awareness of the available and reliable tools. Objectives: The study was designed to compare the nutritional status evaluation of PLWHA using the Malnutrition Universal Screening Tool (MUST) and Subjective Global Assessment (SGA) tool, and to also determine the cut-off values of MUST and SGA that corresponds to underweight with BMI (<18.5kg/m3) as the gold standard. Methodology: The study reviewed records of HIV seropositive patients between May and October 2008 at the antiretroviral clinic, University College Hospital, Ibadan, Nigeria. Clinical symptoms and anthropometric data of 120 PLWHA were extracted from the hospital records for nutritional evaluation by the BMI, MUST, and SGA tools. Descriptive and inferential statistics were employed in data analysis. Cut-off values for MUST and SGA tools in identifying underweight (BMI<18.5) were determined using Receiver Operation Curve (ROC) analysis. Level of significance was placed at p<0.05. Results: Prevalence of underweight was 5.8% (BMI), 75.8% were at high risk of malnutrition (MUST score ≥2) while 42.3% had suspected and severe malnutrition (SGA B&C) respectively. There is a significant difference between MUST and SGA risk of malnutrition X=17.331, p=0.000. ROC curve for MUST was more accurate in identifying underweight compared with SGA (AUC-0.900, CI=0.778 to 1.012, p=0.000 vs AUC-0.700, C.1-0.476 to 0.934, p=0.070). At a MUST score of 3.4 and SGA of 6.0, about 10% and 30% of the underweight respondents were not identified. Conclusion: With the use of MUST and SGA tools, more PLWHA were at risk of malnutrition. Thus, combined use of MUST and SGA gives a better assessment than BMI.
Nutrition-related cancer prevention knowledge of undergraduate students of University of Ibadan, Nigeria.
(Taylor & Francis, 2016) Folasire, O. F.; Folasire, A. M.; Chikezie, S.
Objective: This study assessed the nutrition-related cancer prevention knowledge and dietary pattern of undergraduate students. Design: A cross-sectional study design was employed. Setting: The University of Ibadan campus, Ibadan, Oyo state, Nigeria. Participants: A systematic random sampling of 367 undergraduate students was done. Method: A pretested self-administered questionnaire assessed the nutrition-related cancer prevention knowledge of the participants based on WCRF/AICR guidelines. A food frequency questionnaire was used to evaluate the dietary pattern. Weight, height, waist and hip circumferences, body mass index and waist:hip ratio were measured and computed based on standard procedures. Results: Less than half (49%) had good nutrition-related knowledge of cancer prevention. About 30.0-40.0% frequently consumed legumes/nuts, vegetables and fruits respectively. About 75.0% frequently consumed processed cereals and grains (white rice, white bread and noodles). Above 20.0% were overweight, while 3.8% were obese. Less than 75.0% had low risk of abdominal obesity while 25.5% had high risk of abdominal obesity. Nutrition knowledge of cancer prevention was associated with the frequency of consumption of processed cereals and grains (= 13.724; p=0.000), legumes/nuts (17.268; p=0.000), meat (>= 22.972; p=0.000), fish = 23.017; p = 0.000), pastry snacks (= 36.159; p = 0.000) and sugary drinks (x2= 6.432; p= 0.011). There was no significant difference in knowledge of cancer prevention and the frequency of consumption of roots and tubers, milk, vegetables, and fruits. A higher risk of abdominal obesity was associated with infrequent consumption of legumes/ nuts (x2=7.001, p = 0.008) in the males, and with vegetables (y2= 6.771, p = 0.009) and fruits (x2= 4.205, p = 0.040) intakes in the females. Conclusion: Nutrition-related knowledge of cancer prevention was low, and the respondents also had a poor dietary pattern. The high risk of abdominal obesity may be a pointer to the larger young adult population, emphasising a need for targeted intervention.
Perceived social support among HIV positive and HIV-negative people in Ibadan, Nigeria.
(Scientific Research, 2014) Folasire, O. F.; Akinyemi, O.; Owoaje, E.
Background: People living with HIV and AIDS (PLWHA) are assumed to have poor social support. This study compared the satisfaction with perceived social support of people living with HIV and AIDS with HIV negative patients. Method: 150 HIV positive patients were age and sex matched with 150 HIV negative patients in a cross sectional comparative study. Information on socio-demography and social support was assessed with questionnaire including multidimensional scale of perceived social support (MSPSS). Chi square test, student t-test, and linear regression analysis were done at p = 0.05 level of significance. Result: Mean age of the HIV positive versus HIV negative patients is 38.1 ± 9.0 years versus 37.7 ± 9.2 years. Both groups had the lowest social support scores from family, (FA): 3.81 ± 1.08 vs 3.95 ± 0.89, p = 0.240. Perceived support from friends (FR) was higher in the HIV negative group 7.41 ± 1.99 vs 5.55 ± 2.34, p = 0.000 as well as perceived total support (TS), 3.94 ± 0.68 vs 3.59 ± 0.77, p = 0.000. Linear regression for all the respondents revealed HIV status contributed the most and predicted TS and FR scores respectively (β = −0.181 95% C.I = −5.843 to −0.766, p = 0.010 and β = −0.317, 95% C.I, −4.260 to −1.792, p = 0.000). For PLWHA group, employment contributed most to perceived TS (β = −0.181 95% C.I −11.812 to −0.0361, p = 0.049). However, in HIV negative group, TS and FR had the greatest contribution from marital status, (β = −0.416 95% C.I −6.157 to −1.829, p = 0.000) and (β = −0.381 95% C.I −2.851 to −0.756, p = 0.001). Also, the current living status (β = −0.268, 95% C.I −3.238 to −0.360, p = 0.015, and β = −0.241 95% C.I −1.48 to −0.09, p = 0.027). Conclusion: All respondents had the poorest perception of support from family (FA). Lack of employment is the most important factor identified in this group of PLWHA, responsible for the poor TS. For the HIV negative group, not being married and living outside family setting were the strongest factors for poor social support.
Prevalence of malnutrition among cancer patients in a Nigerian institution
(Lifescience Global, 2017) Ntekim, A.; Folasire, O. F.; Folasire, A. M.
Abstract: Background: Cancer is a major health problem. Successful management includes adequate supportive care. Nutritional problems are common among cancer patients and these are not routinely addressed by oncologists during oncology care leading to suboptimal outcome even in developed countries. In Nigeria and other low and medium income countries, the situation is worse as nutritional screening and assessment of cancer patients are not routinely carried out. Objectives: To determine the proportion of cancer patients at risk of malnutrition and compare convergence of risk assessment using SGA and MUST tools. Methods: This was a prospective study carried out among cancer patients who presented for cancer care in the Department of Radiation Oncology, University College Hospital Ibadan, Nigeria. Nutritional assessment tools which included Malnutrition Universal Scoring Tool (MUST) and Subjective Global Assessment (SGA) were used to assess the nutritional status of the participants. Results: A total of 89 patients aged between 18 and 85 years participated in the study. The number of males were 13 (15%) while females were 76(85%). In our study 54 (60.8%) of our patients were at risk of malnutrition using the malnutrition universal scoring tool (MUST) scale while 53(60%) were malnourished using the subjective global assessment (SGA) scale. The reliability for the classifications using the MUST and SGA scales was positive (moderate) [Kappa = 0.584 (p <0.0005), 95% CI (0.410, 0.758)]. Conclusion: There is a high proportion of clinical malnutrition among cancer patients in the study population. According to this study, there was similarity between the classifications of nutritional risk, using the MUST and SGA tools.
Quality of life of People living with HIV and AIDS attending the Antiretroviral Clinic, University College Hospital, Nigeria
(AOSIS OpenJournals, 2012) Folasire, O. F.; Irabor, A. E.; Folasire, A. M.
Background: Quality of life (QOL) is an important component in the evaluation of the well-being of people living with HIV and AIDS (PLWHA), especially with the appreciable rise in longevity of PLWHA. Moreover, limited studies have been conducted in Nigeria on how PLWHA perceive their life with the World Health Organisation Quality of Life Brief Scale (WHOQOL-Bref) instrument. Objective: This study assessed the QOL of PLWHA attending the antiretroviral (ARV) clinics, UCH Ibadan, Nigeria. Method: A cross-sectional study was conducted from June to September 2008 that involved 150 randomly selected HIV-positive patients who were regular attendees at the antiretroviral clinic, UCH Ibadan. An interviewer administered questionnaire was used to collect information on sociodemographic data, satisfaction with perceived social support, medical records, and QOL was assessed with WHOQOL-Bref. Results: The mean age of the respondents was 38.1 ± 9.0 years and the male : female ratio was 1:2. The mean CD4 count was higher in female patients than in male patients, 407 cells/mm3 : 329 cells/mm3 (p = 0.005). The mean QOL scores on the scale of (0–100) in three domains were similar: psychological health, 71.60 ± 18.40; physical health, 71.60 ± 13.90; and the environmental domain, 70.10 ± 12.00; with the lowest score in the social domain, 68.89 ± 16.70. Asymptomatic HIV-positive patients had significantly better mean QOL scores than symptomatic patients in the physical (74.04 ± 16.85 versus 64.47 ± 20.94, p = 0.005) and psychological domains (76.09 ± 12.93 versus 69.74 ± 15.79, p = 0.015). There was no significant difference in the mean QOL scores of men compared to those of women, in all domains assessed. Conclusion: High QOL scores in the physical, psychological and environmental domains may be reflective of the effectiveness of some of the interventions PLWHA are exposed to at the ARV clinic, UCH Ibadan (on-going psychotherapy, free antiretroviral drugs). Relatively low social domain scores may suggest ineffective social support networks, because PLWHA are still exposed to stigmatisation and discrimination. An improvement in social support for PLWHA, therefore, will improve their quality of life further.