Browsing by Author "Jegede, A."

Now showing 1 - 3 of 3

A cross-sectional study on urogenital schistosomiasis in children; haematuria and proteinuria as diagnostic indicators in an endemic rural area of Nigeria
(Faculty of Medicine, Makerere University, 2014-06) Morenikeji, O.; Qazim, J.; Omoregie, C.; Hassan, A.; Nwuba, R.; Anumudu, C.; Adejuwon, S.; Salawu, O.; Jegede, A.; Odaibo, A.
Background: Rapid and accurate diagnosis is necessary for the management of schistosomiasis in endemic areas. Objective: To assess the burden of urogenital schistosomiasis and the diagnostic efficiency of morbidity indicators of the disease in an endemic rural community of Nigeria. Methods: A cross-sectional school-based study was conducted. Urine samples of 487 pupils were screened microscopically for S. haematobium and tested for haematuria and proteinuria using chemical reagent strips. Results: The prevalence and intensity of infection were 57.1% and 45.0 eggs/10 mL urine respectively. Prevalence of infection in male (54.1%) and female (60.3%) individuals showed no significant variation (P>0.05). However, prevalence of infection was age dependent with those in age groups 3-5 and 12-14 years having the least and highest prevalence of infection respectively (P<0.05). Microhaematuria and proteinuria varied significantly with ages of the pupils with least (14.0, 40.0%) and highest (60.0, 80.0%) prevalence recorded in age groups 3-5 and 15-19 years respectively (P<0.05). Proteinuria showed higher sensitivity (80.3%) compared to microhaematuria (73.3%). Conclusion: Schistosomiasis is highly endemic in the study area and the use of microhaematuria and proteinuria for mapping the infected population prior treatment could be adopted.
Unraveling the ethical, legal, and social implications of neurobiobanking and stroke genomic research in Africa: a studyprotocol of the African neurobiobankfor precision stroke medicine ELSI project
(Sage Publications, 2020) Akinyemi, R. O.; Jenkins, C.; Nichols, M.; Singh, A.; Wahab, K.; Akpalu, A.; Sarfo, F. S.; Owolabi, L. F.; Obiako, R.; Akinyemi, J.; Ojebuyi, B.; Adigun, M.; Musbahu, R.; Bello, A.; Titiloye, M.; Calys-Tagoe, B.; Ogunronbi, M.; Uvere, E.; Laryea, R.; Fakunle, A.; Adeleye, O.; Olorunsogbon, O.; Ojo, A.; Adesina, D.; Mensah, N.; Oguike, W.; Coleman, N.; Mande, A.; Uthman, M.; Kalaria, R. N.; Jegede, A.; Owolabi, M.; Ovbiagele, B.; Arulogun, O.
The ethical, legal, and social implications (ELSI) of emerging neurobiobanks and data resources are unclear in an African scientific landscape with unique cultural, linguistic, and belief systems. The overarching goal of the African Neurobiobank for Precision Stroke Medicine–—ELSI Project is to identify, examine, and develop novel approaches to address ELSI issues of biobanking and stroke genomic research in sub-Saharan Africa (SSA). To accomplish the goal we will (1) explore knowledge, attitude, perceptions, barriers, and facilitators influencing ELSI issues related to biobanking and stroke genomic research; (2) use information obtained to craft a community intervention program focused on ELSI issues; and (3) build capacity and careers related to genomics and biobanking for effective client/community engagement while enhancing regulatory, governance, and implementation competences in biobanking science in SSA. A community-based participatory research and mixed-methodological approach, focused on various levels of the social ecological model, will be used to identify and examine relevant ELSI issues. Contextual intervention tools, platforms, and practices will be developed to enhance community understanding and participation in stroke biobanking and genomics research activities while facilitating enduring trust, and equitable and fair utilization of biobanking resources for genetic and trans-omics research. A concurrent capacity building program related to genetic counseling and biobanking will be implemented for early career researchers. The huge potential for neurobiobanking and genomics research in Africa to advance precision medicine applicable to stroke and other neurological disorders requires addressing ELSI challenges while building sustainable research, career, and regulatory capacities in trans-omics and biobanking science.
Urine turbidity and microhaematuria as rapid assessment indicators for schistosoma haematobium infection among school children in endemic Areas
(Science Publications, 2012) Hassan, A.; Ntiaidem, U.; Morenikeji, O.; Nwuba, R.; Anumudu, C.; Adejuwon, S.; Salawu, O.; Jegede, A.; Odaibo, A.
Problem statement: Urinary schistosomiasis is highly endemic in Nigeria and for effective control measure, an efficient, quick and yet cheap diagnosis should be integrated. This will ensure the proper management of infection due to Schistosoma haematobium in low resource communities of Nigeria. Approach: This cross-sectional study recruited a total of 456 (252 males, 204 females) school children aged 3-20 years between November 2010 and June 2011. Urine samples were examined macroscopically for turbidity and subsequently screened for microhaematuria using diagnostic reagent strips. The microscopic examination of urine samples for schistosome eggs was used as the standard for diagnosis. Results: The prevalence of S. haematobium and geometric mean intensity of infection were 54.8% and 13.9 ± 0.67 eggs/10 mL of urine respectively. The age and sex prevalence of urinary schistosomiasis showed no significant differences (p>0.05). The prevalences of urine turbidity and microhaematuria were 37.1 and 53.9% respectively and these varied significantly across age groups (p<0.05). The sensitivities of urine turbidity and microhaematuria used for the indirect diagnosis of urinary schistosomiasis were 54.8 and 59.3 (p>0.05) with their corresponding specificities 80.2 and 65.8% respectively. Intensity of infection was significantly correlated with the indirect diagnostic methods, urine turbidity (r = 0.203, p<0.01) and microhaematuria (r = 0.487, p<0.01). Conclusion: The possible use of urine turbidity as an indicator for rapid diagnosis of urinary schistosomiasis in low resource communities is implied.