Browsing by Author "Mustapha, A."

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An assessment of ovarian cancer histologic types across the African Diaspora
(2021) George, S. H. L.; Omotoso, A.; Pinto, A.; Mustapha, A.; Sanchez-Covarrubias, A. P.; Umar, U. A.; Umar, A. B.; Oluwasola, T. A. O.; Okolo, C. A.; Anthony, U. U.; Ukekw, F. I.; Bakari, M. A.; Dahiru, A. M. C.; Abdullahi, H. I.; Abimiku, B. A.; Abdurrahman, A.; Usman, A.; Ahmed, S. A.; Usman, H. A.; Kabir, A.; Eleje, G. U.; Chiemeka, M. E.; Nzeribe, E.; Nweke, I.; Kadas, S. A.; Suleiman, D. E.; Ekanem, E.; Uche, U. M.; Paul, J.; Agwu, U. M.; Edegbe, F. O.; Anorlu, R. I.; Banjo, A.; Ajenifuja, K. O.; Fawole, A. A.; Kazeem, I. O. O.; Magaji, F.; Silas, O.; Athanasius, B. P.; Tamunomie, N. K.; Abudu, E. B. K.; Ango, I. G.; Abdullahi K.; Lawal, I.; Kabir, S. A.; Ekanem, V.; Ezeanochie, M.; Yahaya, U. R.; Castillo, M. N.; Bahall, V.; Chatrani, V.; Brambury, I.; Bowe, S.; Halliday, D.; Bruney, G.; Butler, R.; Ragin, C.; Odedina, F.; Chamala, S.; Schlumbrecht, M.; Audu, B.
Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016- December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sexcord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
Can Vascularity Determine Degenerative Behavior of Uterine Fibroids? Huge Parasitic Uterine Fibroid Mass Mimicking an Ovarian Tumor
(Annex Publishers, 2017) Imaralu, J.O.; Mustapha, A.; Yusuf, A.; Aramide, K.
Uterine fibroids have been misdiagnosed for a range of conditions from ovarian to colonic or even retroperitoneal tumors. Apart from the effects of a known and diagnosed fibroid, misdiagnosed fibroids have their own implications for the patient which may include iatrogenic impaired reproductive capability and quality of life. An understanding of fibroid degenerations, especially atypical variants produced by associations between fibroid tumors and bowel or mesentery may help overcome this diagnostic dilemma and aid optimal care. Case Report: The authors report the case of a 30 year old nullipara, who had a huge cystic abdominal tumor with rich vascularity from a broad mesentery, causing complex degenerations and consequently an unusual anatomy. This fibroid tumor was misdiagnosed clinically and at radio-diagnosis for an ovarian malignancy, because of the nature of degenerations that had taken place. Conclusion: An understanding of such atypical degenerations may help to overcome diagnostic dilemma and aid optimal care.
Diagnosing renal failure due to diethylene glycol in children in a resource-constrained setting
(Springer International Publishing, 2012) "Akuse, R. M.; Anyiam, J.; Eke, F. U.; Ademola, A. D.; Fajolu, I. B.; Gbelee, H. O.; Ihejiahi, U.; Bugaje, M. A.; Anochie, I. C.; Asinobi, A. O.; Okafor, H. U.; Adeleke, S. I.; Audu, L. I.; Otuneye, A.; Disu, E.; Idris, H.; Aikhonbare, H.; Yakubu, A.; Ogala, W.; Ogunrinde, O.; Wammanda, R.; Orogade, A.; Eseigbe, E.; Umar, L.; Musa, H.; Onalo, R.; West, B.; Paul, N.; Lesi, F.; Ladapo, T.; Boyede, O.; Okeowo, R.; Mustapha, A.; Akinola, I.; Chima-Oduko, O.; Awobusuyi O.
Background In 2008, several Nigerian children developed acute kidney injury (AKI) after ingesting teething syrup contaminated with diethylene glycol (DEG). Because there are limited diagnostic facilities in resource constrained countries, this study investigated whether AKI associated with DEG could be identified by other means. Methods: This was a multicenter study. Information was obtained from hospital records. Clinicopathological features of all children withAKI over a 6-month period were reviewed. Results Sixty (50.4%) of 119 children ingested “My pikin” teething syrup. Compared to children who had not ingested it, they were significantly (p<0.05) younger (11.95 vs. 31 months), more were anuric (98.3 vs. 74.6%), hypertensive (84 vs. 52%), had severe metabolic acidosis (46.7 vs. 20.5%), and died (96.6 vs. 71.2%). They developed increasing metabolic acidosis and multiorgan dysfunction despite peritoneal dialysis. Late presentation, financial difficulties, inadequate facilities for toxicology, and hemodialysis complicated management. Conclusions Identifying AKI associated with DEG is difficult. Detailed drug history, increasing metabolic acidosis, and multiorgan deterioration despite peritoneal dialysis should arouse suspicion. Simple diagnostic tests need to be developed and facilities for hemodialysis of infants and financial support provided. Recurrences can be prevented by creating awareness, improving manufacturing practices, field-testing of drugs, and international monitoring of pharmaceuticals imported for manufacture.