Browsing by Author "Ngwumohaike, V."

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    Clinical manifestations and immune response to MSP 119 in severe paediatric malaria in Adeoyo state maternity hospital, Ibadan
    (College of Medicine, University of Ibadan and the University College Hospital, 2004) Anumudu, C. I.; Okafor, C. M. F.; Ngwumohaike, V.; Afolabi, K. A.; Nwuba, R. I.; Nwagwu, M.
    A 10-week cross-sectional study was carried out at the Adeoyo State Maternity Hospital (Beere, Ibadan), Southwestern Nigeria in order to determine (a) the prevalence of severe malaria, (b) identify the predominant clinical presentations that characterise the disease in children below 5 years and the pattern of antibody responses to MSP 119 elicited in severe malaria complications. Three thousand, one hundred and thirty-one cases reported to the Out Patients' Department; of these, 372 (11.8%) subjects were recruited on the basis of doctors' diagnosis of severe malaria, malaria and other complications. Six per cent (188/3131) of the patients were admitted. Serum samples for 320 of the 372 subjects were analysed for antibodies specific to MSP 119 by ELISA. The highest antibody responses occurred in the age group 2-5 years. Parasite prevalence was 77.9% (290 of 372 subjects) and parasite density ranged from 80 to >100000 parasites/uL blood. Fever (an average temperature of 38.6 ±0.4°C and peak at 41°C) and severe malaria were the major clinical manifestations of rnalaria amongst the study population. Severe malaria was found to be associated with other features such as cough, vomiting and diarrhoea.
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    Epidemiological factors that promote the development of severe malaria anaemia in children in Ibadan
    (Faculty of Medicine, Makerere University, 2007) Anumudu, C. I.; Okafor, C. M. F.; Ngwumohaike, V.; Afolabi, K. A.; Nwuba, R. I.; Nwagwu, M.
    Background: Effective control and management of severe malaria cases depends on a clear understanding of the local epidemiological factors and specific clinical manifestations of the disease in the different endemic regions. Objectives: To determine the prevalence of severe malaria and epidemiological factors that affect the development of malaria anaemia. Methods: A cross-sectional survey was carried out among children below 5 years of age, at the Adeoyo State Maternity Hospital, Ibadan, Nigeria. Questionnaires and case histories were taken from patients clinically diagnosed of malaria. Thus, 372 volunteers were recruited into the study from the 3131 paediatric cases that reported over the10-week period to the out-patient department (OPD) of the hospital. 229 (61.6%) of the recruited volunteers presented with fever (>37.5 oC) at consultation. These had malaria parasite and PCV tests done. Results: Clinical diagnosis was confirmed microscopically in 78% (290/372) for Plasmodium infection using thick film slides. Anaemia (PCV <28%) prevalence was 28.2%. Factors that contributed to the rapid progression of uncomplicated malaria to severe status included: age of the child, level of parasitaemia, careless response and attitude of parents or guardians to fever in the children; parents’ preoccupation with their jobs or other healthy children and unwillingness to use available health facilities. Conclusion: The study underscores the need for community involved partnership for malaria control especially through health education for the home management of malaria, especially among those experiencing some form of inequity in access to healthcare.