Browsing by Author "Odeniyi, A. O."

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Antibody levels against rabies among occupationally exposed individuals in a Nigerian University
(2010) Olugasa, B. O.; Odeniyi, A. O.; Adeogun, A. O.|; Adeola, O.A
The authors investigated the levels of antiglycoprotein antibodies against rabies virus in the sera of occupationally exposed humans at the University of Ibadan, Nigeria. A quantitative indirect enzyme‐linked immunosorbent assay (ELISA) was used to detect rabies virus anti‐glycoprotein antibodies in sera from 20 zoological garden workers, 20 veterinarians and 30 clinical veterinary students at the University of Ibadan. The sera were obtained between September 2008 and February 2009. Of these 70 healthy individuals, 29 (41.4%) consisting of 15 zoological garden workers (75.0%), 13 veterinarians (65.0%) and 1 veterinary student (3.3%) were immune to rabies virus (antibody titre >0.5 equivalent units per ml), while 41 (58.6%) were not immune. The prevalence of rabies anti‐glycoprotein antibody was higher within the older segment of the study population than among the younger veterinary students. Almost all those who had spent at least 10 years on the job had higher levels of rabies vaccination compliance and were immune. Our results indicated that there is low anti‐rabies immunity among occupationally exposed individuals at the University of Ibadan. There is a need for a complete course of primary and booster vaccinations of professionals exposed to the rabies virus. The impact of these results on rabies control in Nigeria is discussed.
Phytochemical screening and microbial inhibitory activities of ficus capensis
(2012-01) Adebayo-Tayo, B. C.; Odeniyi, A. O.
Ficus plant components have application in traditional medicine because of the myriad uses they have been subjected to. The ease of application is based on the secondary metabolites this plant contains. The challenges faced by modern medicine especially in the complete cure of microbially-associated diseases through abrupt and unpredictable genetic mutations in the presence of conventional drugs informed the investigation of the microbial inhibitory activities of the stem, root and leaf parts of F. capensis against test disease causing microorganisms. The phenolic, alkaloid and tannin phytochemical fractions were highest in F. capensis bark extract (180, 165 and 155 μg/ml respectively) followed by that contained in the stem extract (100, 90 and 85 μg/ml respectively). While Streptococcus faecalis and Pseudomonas mirabilis were resistant to many different antibiotics (87.5%), they were effectively inhibited by all concentrations of ethanolic F. capensis extracts. The minimum inhibitory concentration of ethanolic extracts ranged from 25% leaf and stem extract concentration respectively (4mm) against S. faecalis and (2mm) against P.mirabilis. All test isolates were 100% susceptible to ethanol extract growth inhibition..