Browsing by Author "Ogunniyi, A."

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Factors associated with obesity and weight reduction among people with obesity: A systematic review
(ScopeMed, 2020) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Ogunniyi, A.
Introduction: Obesity is a non-communicable disease of huge public health importance with several multi-systemic complications. Weight reduction techniques are useful in the management of obesity. The aim of this review was to determine the risk factors, health risks of obesity as well as factors influencing weight reduction among individuals with obesity. Methods: Google, Google Scholar, and Pub Med databases were used to identify studies on obesity that assessed risk factors and complications of obesity plus factors influencing weight reduction among people with obesity. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were used and 914 literature records were retrieved. These were limited to papers published in English up to 2019. We excluded 702 articles that did not match our theme and also excluded an additional 156 full articles due to incompleteness. The evidence available was critically appraised in line with our objectives. Results: Fifty-six articles were reviewed, and it was found that obesity increased with age and was more in women. Inadequate diet, physical inactivity, and metabolic disor¬ders were contributory factors, whereas the main factors associated with greater weight reduction were lower pre-treatment weight, lower waist circumference, doctors as role models, and absence of psychiatric co-morbidities. Conclusions: Proven weight reduction methods are vital for the cost-effective manage¬ment of patients as part of lifestyle modification.
Frailty and mortality among older patients in a tertiary hospital in Nigeria.
(Ghana Medical Association (Accra, Ghana), 2019) Adebusoye, L. A.; Cadmus, E.O.; Owolabi, M.O.; Ogunniyi, A.
Background: This study determined the frailty status and its association with mortality among older patients. Design: A prospective cohort design. Setting: Study was conducted at the medical wards of University College Hospital, Ibadan, Nigeria. Participants and study tools: Four hundred and fifty older patients (>60 years) were followed up from the day of admission to death or discharge. Information obtained includes socio demographic characteristics and clinical frailty was assessed using the Canadian Study of Health and Aging (CSHA) scale. Bivariate and multivariate analyses were carried out using SPSS version 21 at a p <0.05. Results: Overall, frailty was identified in 285 (63.3%) respondents. Mortality was significantly higher among frail respondents (25.3%) than non-frail respondents (15.4%) p=0.028. Logistic regression analysis showed factors associated with frailty were: male sex (OR=1.946 [1.005–3.774], p=0.048), non-engagement in occupational activities (OR=2.642 [1.394–5.008], p=0.003), multiple morbidities (OR=4.411 [1.944–10.006], p<0.0001), functional disability (OR=2.114 [1.029–4.343), p=0.042], malnutrition (OR=9.258 [1.029–83.301], p=0.047) and being underweight (OR=7.462 [1.499–37.037], p=0.014). Conclusion: The prevalence of frailty among medical in-hospital older patients is very high and calls for its prompt identification and management to improve their survival.
Hiv-1 central nervous system compartmentalization and cytokine interplay in non-subtype B Hiv-1 infections in Nigeria and Malawi
(Mary Ann Liebert, Inc., 2020) Adewumi, O. M.; Dukhovlinova, E.; Shehu, N. Y; Zhou, S.; Council, O. D.; Akanbi, M. O.; Taiwo, B.; Ogunniyi, A.; Robertson, K.; Kanyama, C.; Hosseinipour, M. C.; Swanstrom, R.
"HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cerebrospinal fluid (CSF). However, little is known about CNS compartmentalization in other HIV-1 subtypes. Using a deep sequencing approach with Primer ID, we conducted a cross-sectional study among Nigerian and Malawian HIV-1 cohorts with or without fungal Cryptococcus infection diagnosed as cryptococcal meningitis (CM) to determine the extent of CSF/CNS compartmentalization with CM. Paired plasma and CSF samples from 45 participants were also analyzed for cytokine/chemokine levels. Viral populations comparing virus in the blood and the CSF ranged from compartmentalized to equilibrated, including minor or partial compartmentalization or clonal amplification of a single viral sequence. The frequency of compartmentalized viral populations in the blood and CSF was similar between the CM- and CM+ participants. We confirmed the potential to see compartmentalization with subtype C infection and have also documented CNS compartmentalization of an HIV-1 subtype G infection. Cytokine profiles indicated a proinflammatory environment, especially within the CSF/CNS. However, sCD163 was suppressed in the CSF in the presence of CM, perhaps due to elevated levels of IL-4, which were also a feature of the cytokine profile, showing a distinct cytokine profile with CM.
Predictors of weight reduction in a Nigerian family practice setting
(Ghana Medical Association, 2021) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Adebusoye, L. A.; Ogunniyi, A.
Objectives: This study identified the predictors of weight reduction among adult obese patients in a Family Practice Setting and developed a statistical model to predict weight reduction. Design: A prospective cohort design. Setting: The Family Practice Clinic, University College Hospital, Ibadan, Nigeria Participants and study tools: Obese adults were recruited into a three-month weight reduction program. Patient Information Leaflets were used for counselling, while questionnaires were administered to obtain socio-demographic and lifestyle factors. Potential predictors were assessed using the Multidimensional Scale of Perceived Social Support, Zung Depression Scale, Rosenberg Self-Esteem scale, Garner’s Eating Attitude Test-26 (EAT-26), 24-hour dietary recall and International Physical Activity Questionnaire-short form. Anthropometric indices, blood pressure and Fast-ing Lipid Profile were assessed. Descriptive and inferential statistics were used for analysis with a significance set at α0.05. Results: Most 99(76.2%) of the 130 participants achieved weight reduction and had a median weight change of -2.3kg (IQR-4, -0.5), with 66 (66.7%) out of 99 attaining the weight reduction target of 10%. The regression model showed predictors of weight reduction to be Total Cholesterol [TC] (p=0.01) and Low-Density Lipoprotein Cholesterol [LDL-C] (p=0.03). The statistical model derived for Weight reduction = 0.0028 (LDL-C) -0.029 (TC)-0.053 (EAT-26) +0.041(High-Density Lipoprotein Cholesterol). The proportion of variance of the model tested was R2 = 0.3928 (ad-justed R2 = 0.2106). Conclusion: Predictors of weight reduction among patients were eating attitude score, Total Cholesterol, Low-Density Lipid and High-Density Lipoprotein Cholesterol levels. A statistical model was developed for managing obesity among patients.
Psychiatric disorders and adherence to antiretroviral therapy among a population of HIV-infected adults in Nigeria
(Sage publications, 2016) Adejumo, O.; Oladeji, B.; Akpa, O.; Malee, K.; Baiyewu, O.; Ogunniyi, A.; Evans, S.; Berzins, B.; Taiwo, B.
Psychiatric disorders are common among HIV patients in Nigeria. Adherence is necessary to optimize the outcome of antiretroviral therapy. In this study, we aimed to identify associations between antiretroviral adherence measured by 1-week and 1-month self-reported missed doses, and psychiatric illness in a cohort previously assessed for psychiatric disorders using the Composite International Diagnostic instrument (CIDI). The study participants comprised 151 adults with major depression, anxiety or suicidal symptoms, and 302 matched-control participants. Two controls were randomly selected for each case within the same gender and education stratum. We compared participants with psychiatric disorders (WPDs) and without psychiatric disorders (NPDs) on selected demographic and clinical variables, in addition to adherence. Participants with 1 or more missed doses in the preceding month had twice the odds of having a major depressive episode as those with no missed doses during this period (OR 2.22, 95% CI 1.03, 4.79). This association remained significant after adjusting for selected risk factors. There was no statistically significant difference between WPD and NPD groups on either 1-week or 1-month adherence, or on age, marital status, occupational class, HIV viral load at enrollment or current CD4. Among Nigerian adults with HIV, suboptimal antiretroviral adherence is associated with, and could be a Corresponding author: Olurotimi Adejumo, Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria, Phone: +2348033778540, +13122167417, radejumo@yahoo.com. HHS Public Access Author manuscript Int J STD AIDS. Author manuscript; available in PMC 2016 October 01. Published in final edited form as: Int J STD AIDS. 2016 October ; 27(11): 938–949. doi:10.1177/0956462415600582. Author Manuscript Author Manuscript Author Manuscript Author Manuscript pointer to depression. Routine self-report adherence assessments may have potential utility for identifying individuals at risk among this population.
Rapid HIV Antigen–Antibody Assays and detection of acute HIV infection in sub-saharan Africa
(American Society of Tropical Medicine and Hygiene, 2019) Adetunji, A. A.; Adewumi, M. O.; Michael, O. S.; Fayemiwo, S. A.; Ogunniyi, A.; Taiwo, B. O.
Detection of acute HIV infection is a unique problem that fourth-generation HIV assays were expected to alleviate. In this commentary, we draw attention to the limitations and challenges with use of currently available rapid antigen–antibody (Ag/Ab) combination tests for detection of acute HIV infection in sub-Saharan Africa. Laboratory-based HIV-1 Ag/Ab immunoassays are complex, requiring specialized equipment and handling that are currently not affordable in many settings in Africa. The point-of-care Ag/Ab platform on the other hand is easier to deploy and potentially more accessible in resource-limited settings. However, available fourth-generation HIV-1 rapid diagnostic tests have demonstrated poor performance characteristics in field studies where non-B subtypes of HIV-1 dominate. The potential for point-of-care HIV-1 Ag/Ab diagnostics to significantly improve detection of acute HIV infection remains yet to be realized in sub-Saharan Africa. Assay platforms need to be optimized to identify local circulating subtypes, and optimal algorithms need to be determined
Role of transcranial colour-coded duplex sonography in stroke management
(West Africa Medical Ultrasound Society, 2015) Olatunji, R. B.; Ogbole, G. I.; Atalabi, O. M.; Adeyinka, A. O.; Lagunju, I.; Oyinlade, A.; Ogun, O.; Owolabi, M.O.; Ogunseyinde, O. A.; Ogunniyi, A.
The development of transcranial colour-coded duplex sonography (TCCS) has resurrected the hope of safe, real time bedside brain imaging beyound childhood. This review article provides an overview of the role of TCCS in the management of patients with stroke. The objective is to stimulate interest in the field of neurosomology as a potential means of improving neurological outcome for stroke patients and a area for stroke research endeavours in Africa. Literature search was done on MEDLINE, Cochrane library, and GoogleScholar database with the following keywords: transcranial colour Doppler, Transcranial duplex sonography,stroke, infarct and haemorrhage. We also identified relevant articles from the references section of studies produced by our literature search. We discussed the roles of TCCS to discriminate ischaemic from haemorrhagic forms; unravel the mechanism of stroke; monitor temporal evolution of stroke and predictors of stroke outcome; and promote better understanding of the epidemiology of stroke. It emerging role as a potent point-of-care imaginf modality for definitive treatment in ischaenic stroke within and outside the hospital setting is also highlighted. Comparison of TCCS with alternative modalities for neuroimaging for stroke patients in Africa is presented vis-a-vis the potential economic relief which widespread adoptionof TCCS may provide. We advocate capacity building for TCCS and suggest some action plans required to achieve safe, cheap, affordable and reliable ultrasound based neuroimaging for stroke patients in resource limited areas of Africa.
Self-reported sleep disorder and ambulatory blood pressure Phenotypes in patients with or without chronic kidney disease: findings from Ibadan CRECKID study.
(2019) Ajayi, S.O.; Adeoye, A.M.; Raji, Y.R.; Tayo, B.; Salako, B.L.; Ogunniyi, A.; Ojo, A.; Cooper, R.
ed the relationship between self-reported sleep disorders, and ambulatory blood pressure phenotypes in patients with hypertension and those with or without CKD. METHODS: Participants aged 18 years and above who consented were recruited into the study. Anthropometric measurements including height, weight, and waist and hip circumferences were obtained, Office/clinic hypertension was defined as SBP ≥140mmHg and/or DBP ≥90mmHg or being on pharmacological treatment for hypertension. 24-hour ambulatory blood pressure monitoring were done. Obstructive sleep apnea was assessed using Stop Bang questionnaire. Estimated GFR was calculated using CKD-EPI Creatinine 2 Equation and CKD was defined as eGFR 60ml/min?1.73m2 Results: A total of three hundred and forty-nine (349) patients were enrolled for the study: 175 males and 174 females. Moderate to severe risk for obstructive sleep apnea (OSA) was observed in 51.4% of patients with CKD, 58.5% of hypertensive and 17.3% of apparently healthy participants. Male participants were more likely than female patients to have moderate and high OSA risk (41.7% vs 32.8%) and (10.3% vs 4.6%) respectively. Compared with other groups, CKD patients had the highest office and ambulatory blood pressure parameters; Conclusion: This study has demonstrated that obstructive sleep apnoea is prevalent among patients with chronic kidney disease and hypertension. Furthermore, the phenotypes of hypertension are accentuated in CKD and therefore, OSA may well be an important risk factor for CKD.
Weight control, alcohol reduction, smoking cessation, health promotion, exercise and diet (WASHED)’: a mnemonic for lifestyle modification in obesity
(Department of Family Medicine, University College Hospital, Ibadan, 2015) Ogunbode, A. M.; Owolabi, M. O.; Ogunniyi, A.; Ogunbode, O. O.
What’s in your hands? A systematic review of dietary assessment methods and estimation of food sizes in a Primary Care Clinic
(Wolters Kluwer - Medknow, 2018) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Ogunniyi, A.
Introduction: Many patients with non-communicable diseases such as obesity are attended to in Family Practice Clinics where quick dietary assessment along with estimation of food sizes as part of lifestyle modification and appropriate intervention could be offered. We performed a systematic review to determine the dietary assessment methods with the best evidence that can be employed in a Family Practice Clinic. Methods: Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines were used to conduct a systematic review of PubMed, Google, and Google Scholar databases from 1992 to 2017. Results: We found 730 original research articles, case–control studies, review articles, proceedings, transactions, and textbooks. Thirty-seven articles were selected out of which two were secondary data, 12 were review articles, 10 were descriptive surveys, and one was a prospective cohort study. There were two randomized controlled trials, two mixed study designs, one working paper, and seven guides. Food portion size estimation using household objects and the hand guide, then the food pyramid guide along with the food-sized plate intervention was documented. Conclusion: In view of the busy nature of Family Practice Clinics in several countries, in performing dietary assessment, food portions can be estimated using household measures and the hand portion guide. The pyramid guide and the portion-sized plate can then be used for intervention.
What’s in your hands? A systematic review of dietary assessment methods and estimation of food sizes in a Primary Care Clinic
(Wolters Kluwer - Medknow, 2018) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Ogunniyi, A.
Introduction: Many patients with noncommunicable diseases such as obesity are attended to in Family Practice Clinics where quick dietary assessment along with estimation of food sizes as part of lifestyle modification and appropriate intervention could be offered. We performed a systematic review to determine the dietary assessment methods with the best evidence that can be employed in a Family Practice Clinic. Methods: Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines were used to conduct a systematic review of PubMed, Google, and Google Scholar databases from 1992 to 2017. Results: We found 730 original research articles, case–control studies, review articles, proceedings, transactions, and textbooks. Thirty-seven articles were selected out of which two were secondary data, 12 were review articles, 10 were descriptive surveys, and one was a prospective cohort study. There were two randomized controlled trials, two mixed study designs, one working paper, and seven guides. Food portion size estimation using household objects and the hand guide, then the food pyramid guide along with the food-sized plate intervention was documented. Conclusion: In view of the busy nature of Family Practice Clinics in several countries, in performing dietary assessment, food portions can be estimated using household measures and the hand portion guide. The pyramid guide and the portion-sized plate can then be used for intervention.