Browsing by Author "Owolabi, M. O."

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Agro-physiologic effects of compost and biochar produced at different temperatures on growth, photosynthetic pigment and micronutrients uptake of maize crop
(Academic Journals., 2016) Adejumo, S. A.; Owolabi, M. O.; Odesola, I. F.
The production and use of biochart and compost present many opportunities for soil improvement and agricultural productivity. However, the yield and performance of biochar depend on the feedstocks, pyrolysing temperatures and rate of application. Experiments were conducted to find out the effect of compost and biochar produced from two different feed stocks (Rice husk and Mexican sunflower) and pyrolysed at different temperatures (300, 350 and 400°C) on the growth, yield, nutrient uptake and chlorophyll contents of maize (Zea mays L.,). These were applied at three levels (5, 10 and 15 ton/ha) and the pots were laid out in a Completely Randomized Design (CRD) with four replicates. Data were collected on growth and yield attributes of maize, photosynthetic pigments and nutrient uptake by maize crop.The results showed that the feedstock pyrolyzed at temperature between 300 to 350°C and compost applied at higher rate between 10 to 15 ton/ha performed better. On the growth and yield parameters, compost and biochar at relatively low temperature and applied at 15 t/ha performed better than other treatments including control both at the main and residual experiments On the residual effect, the two types of biochar performed better than compost most especially sunflower biochar pyrolysed at 300 and 350°C and applied at 15 t/ha. The chlorophyll formation was enhanced more in maize treated with higher rates of biochar than lower rates. The result indicates that depending on feedstock, biochar and compost have potentials to serve as nutrient sources.
Bell's palsy in pregnancy and the puerperium: a report of five cases
(College of Medicine, University of Ibadan, 2010) Fawale, M. B.; Owolabi, M. O.; Ogunbode, O.
The incidence of idiopathic facial nerve palsy is higher during pregnancy and the puerperium than in non-pregnant women of childbearing age. An important association also exists between Bell’s palsy and hypertensive disorders of pregnancy. We describe three patients with idiopathic facial nerve palsy in pregnancy and two in the puerperium. Two of these were associated with hypertensive disorder of pregnancy. This case report illustrates the fact that Bell’s palsy is common in pregnancy and in the puerperium and often associated with hypertensive disorders of pregnancy. Association also exists between Bell’s palsy and hypertensive disorders of pregnancy [1].The clinical manifestation is the same in pregnancy as in the general population, although, it tends to run a more severe course in the former [5]. Rarely, patients have recurrent Bell’s palsy in successive pregnancies [5]. Short course of steroids early in the course of the disease has been used with some evidence of benefit [7]. We present a crop of five cases of Bell’s palsy who we saw in quick succession within a few months at the Neurology Unit of the Department of Medicine, University College Hospital, Ibadan.
Can common carotid intima media thickness serve as an indicator of both cardiovascular phenotype and risk among black Africans?
(Sage publications, 2014) Owolabi, M. O.; Agunloye, A. M.; Umeh, E. O.; Akpa, O. M.
Background: It is not known whether common carotid intima media thickness (CIMT) can serve as a surrogate marker of cardiovascular risk among black Africans. Therefore, we examined whether CIMT differed significantly among individuals with distinct cardiovascular phenotype and correlated significantly with traditional cardiovascular risk factors in a black African population Methods: CIMT was measured in 456 subjects with three distinct cardiovascular phenotypes – 175 consecutive Nigerian African stroke patients, 161 hypertensive patients without stroke and 120 normotensive non-smoking adults. For each pair of cardiovascular phenotypes, c-statistics were obtained for CIMT and traditional vascular risk factors (including age, gender, weight, waist circumference, smoking, alcohol, systolic and diastolic blood pressures, fasting plasma glucose, fasting total cholesterol). Pearson’s correlation coefficients were calculated to quantify bivariate relationships. Findings: Bilaterally, CIMT was significantly different among the three cardiovascular phenotypes (right: p < 0.001, F ¼ 33.8; left: p < 0.001, F ¼ 48.6). CIMT had a higher c-statistic for differentiating stroke versus normotension (c ¼ 0.78 right; 0.82 left, p < 0.001) and hypertension versus normotension (c ¼ 0.65 right; 0.71 left, p < 0.001) than several traditional vascular risk factors. Bilaterally, combining all subjects, CIMT was the only factor that correlated significantly (right: 0.12 r 0.41, 0.018 p < 0.0001; left: 0.18 r 0.41, 0.005 p < 0.0001) to all the traditional cardiovascular risk factors assessed. Conclusion: Our findings support CIMT as a significant indicator of both cardiovascular risk and phenotype among adult black Africans. However, specific thresholds need to be defined based on prospective studies.
Carotid IMT is more associated with stroke than risk calculators
(John Wiley & Sons Ltd., 2015) Owolabi, M. O.; Akpa, O. M.; Agunloye, A. M.
Background – It is unclear whether a natural marker of atherosclerosis (carotid intima-media thickness: CIMT) or calculated risk score is more associated with stroke. We therefore comparatively examined the relationship between CIMT as well as two cardiovascular risk calculators (Omnibus Risk Score -ORS and Framingham Risk Score- FRS) and the occurrence of stroke among hypertensive African patients. Methods – CIMT was measured in 555 consecutive consenting hypertensive adults (377 stroke patients and 178 strokefree subjects). The 10-year cardiovascular risk was calculated for each participant with the FRS and ORS. The strengths of association between FRS, ORS, CIMT, and stroke occurrence were examined using logistic regression. The discriminative capacity of FRS, ORS, and CIMT for stroke occurrence was assessed with c-statistics. Results – Higher average CIMT (OR 11.71; 95% CI 1.65–83.07; P = 0.01) was strongly associated with stroke after adjusting for age, sex, blood pressure, serum cholesterol, and blood sugar. Neither the FRS (OR: 1.03; CI: 0.89–1.19, P = 0.68) nor the ORS (OR: 1.08; CI: 0.90–1.30; P = 0.41) was significantly associated with stroke. CIMT had a higher c-statistic for differentiating stroke patients from hypertensive controls (right: c = 0.63, P < 0.001; left: c = 0.67, P < 0.001; average: c = 0.66, P < 0.001) than some conventional risk factors. Neither FRS (P = 0.39) nor ORS (P = 0.55) was able to independently differentiate between stroke and hypertensive patients. Conclusion – CIMT, but neither FRS nor ORS, is independently associated with stroke among Nigerian African hypertensive patients. CIMT may be a better tool for estimating the overall risk of stroke than FRS or ORS in this population.
Data resource profile: Cardiovascular H3Africa Innovation Resource (CHAIR)
(Oxford University Press, 2018-12) Owolabi, M. O.; Onoja, M. A.; Made, F.; Adebamowo, S. N.; Ojo, A.; Dwomoa, A.; Motala, A. A.; Bongani, M.M.; Ovbiagele, B.; Adebamowo, C.; Bamidele, T.; Rotimi, C.; Akinyemi, R.; Gebregziabher, M.; Sarfo, F.; Wahab, K. W.; Parekh, R. S.; Engel, M. E.; Chisala, C.; Peprah, E.; Mensah, G.; Wiley, K.; Troyer, J.; Miche` le, R.
Low- and middle-income countries (LMIC) constitute the majority of the world’s population and bear more than 80% of the global burden of cardiovascular disease (CVD).1,2 The recent increases in CVD globally are also reflected in LMIC, where the prevalence of overall deaths from CVD was 28% in 20013 and premature CVD mortality was 37% in 2015.4 The paucity of data regarding the drivers of the CVD epidemic and contextualized solutions is, in part, because less than 10% of the global research resources and facilities for implementation are found in LMIC.5,6 Therefore LMIC are particularly disadvantaged in dealing with the CVD burden with...
Development and Evaluation of a Primary HealthCare-based Physiotherapy Intervention and its Effects on Selected Indices of Stroke Recovery
(MA Healthcare Ltd, 2013) Olaleye, O. A.; Hamzat, T. K.; Owolabi, M. O.
Aim: To develop a Primary Healthcare-Based Physiotherapy Intervention (PHCPI) that requires simple, inexpensive, easy-to-use equipment for stroke rehabilitation and evaluate its effects on selected clinical indices of recovery among post-acute stroke survivors over a 10-week period. Methods: Three databases (Medline, Pubmed and PEDro) were used to identify treatment approaches with proven efficacy. The authors synthesised these treatment approaches to develop the PHCPI, which was used in a repeated measure design involving 25 (mean age=60.6 ± 10.2 years) consenting individuals with first-incidence stroke. These individuals were treated at a primary health centre, twice weekly for 10 consecutive weeks. Outcomes were assessed using the Modified Motor Assessment Scale (MMAS), the Short Form Postural Assessment Scale for Stroke (SF-PASS) and the Reintegration to Normal Living Index (RNLI), before the intervention and fortnightly thereafter. Walking speed and quality of life were also assessed before the intervention and at week 10 of it. Results: Within-subject multivariate analysis, after controlling for gender, showed a significant increase in motor function, postural balance, walking speed and quality of life. Their community reintegration scores also improved over the period. Conclusion: The PHCPI resulted in improved motor function, community reintegration, walking speed, postural balance and quality of life among community-dwelling stroke survivors. This intervention can be used for stroke rehabilitation at primary health centres.
Factors associated with obesity and weight reduction among people with obesity: A systematic review
(ScopeMed, 2020) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Ogunniyi, A.
Introduction: Obesity is a non-communicable disease of huge public health importance with several multi-systemic complications. Weight reduction techniques are useful in the management of obesity. The aim of this review was to determine the risk factors, health risks of obesity as well as factors influencing weight reduction among individuals with obesity. Methods: Google, Google Scholar, and Pub Med databases were used to identify studies on obesity that assessed risk factors and complications of obesity plus factors influencing weight reduction among people with obesity. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were used and 914 literature records were retrieved. These were limited to papers published in English up to 2019. We excluded 702 articles that did not match our theme and also excluded an additional 156 full articles due to incompleteness. The evidence available was critically appraised in line with our objectives. Results: Fifty-six articles were reviewed, and it was found that obesity increased with age and was more in women. Inadequate diet, physical inactivity, and metabolic disor¬ders were contributory factors, whereas the main factors associated with greater weight reduction were lower pre-treatment weight, lower waist circumference, doctors as role models, and absence of psychiatric co-morbidities. Conclusions: Proven weight reduction methods are vital for the cost-effective manage¬ment of patients as part of lifestyle modification.
Impact of dietary intervention on selected biochemical indices of inflammation and oxidative stress in Nigerians with metabolic syndrome: a pilot study
(2014) Rahamon, S. K.; Charles-Davies, M. A.; Akinlade, K. S.; Olaniyi, J. A.; Fasanmade, A. A.; Oyewole, O. E.; Owolabi, M. O.; Adebusuyi, J. R.; Hassan, O. O.; Ajobo, B. M.; Ebesunun, M. O.; Adigun, K.; Fabian, U. A.; Popoola, O. O.; Okunbolade, W.; Arinola, O. G.; Agbedana, E. O.
Aim: This study assessed the impact of dietary modification on cardiometabolic, inflammatory and oxidative stress indices in Nigerians with metabolic syndrome (MS). Subjects and Methods: Sixty participants with MS were selected using the International Diabetes Federation criteria from a cohort participating in “Risk Assessment of Type 2 diabetes mellitus and Dementia in Nigerians with Metabolic Syndrome” study. The subjects were seen by a Dietitian and the approximate percentages of total calories from total protein, total fat, polyunsaturated fat, and carbohydrate were calculated from dietary history and pegged at 20%, 30%, 14% and 50% respectively. To ensure compliance, each participant was seen monthly (for 6 months) by the Dietitian. Glucose and lipid profile were determined using enzymatic methods. Serum activities of superoxide dismutase (SOD), catalase (CAT), Myeloperoxidase (MPO) and levels of nitric oxide (NO), malondialdehyde (MDA), hydrogen peroxide (H2O2), total protein and albumin were determined using spectrophotometric methods while high sensitivity C-reactive protein (hsCRP) and tumuor necrosis factor-alpha (TNF-α) were determined using ELISA. Student’s t-test (paired) and Wilcoxon signed-rank test were used for statistical analysis as appropriate. P-value <0.05 was considered significant. Results: The mean blood pressure (BP), body mass index (BMI), waist circumference(WC), hip circumference (HC), body fat, NO, hsCRP, H2O2, total protein and globulin were significantly reduced while the mean HDL, MDA, albumin and activities of CAT and MPO were significantly increased post-dietary modification compared with baseline. Conclusion: Short-term dietary intervention improved cardiovascular risk, inflammation and oxidative stress indices in Nigerians with MS.
Indices of metabolic syndrome in 534 apparently healthy traders
(David Publishing, 2012-02) Charles-Davies, M. A.; Arinola, O. G.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Hassan, O. O.; Ajobo, M. T.; Adigun, K.; Akinlade, K. S.; Adebusuyi, J. R.; Ebesunun, M. O.; Popoola, O. O.; Okunbolade, W.; Fabian, U. A.; Rahamon, S. K.; Ogunlakin, M. A.; Agbedana, E. O.
Background: Metabolic Syndrome (MS) increases the risk of developing type-2 diabetes (DM2) and cardiovascular diseases (CVD) and it is thought to be prevalent in Nigeria. This study aims at determining the prevalence of MS and its component risk factors among apparently healthy traders in a local market in Ibadan, Nigeria. Methods: 534 apparently healthy traders from a local market in Bodija, Ibadan, Nigeria aged (18–105) years with neither DM2 nor CVD were participants of a cohort study on risk assessment of type 2 diabetes and dementia in Nigerians with metabolic syndrome. The International Diabetes Federation (2005) and the World Health Organisation (1998) criteria were used for MS and BMI respectively. Anthropometric indices (weight, height, body mass index (BMI), percentage body fat (PBF), waist and hip circumferences (WC & HC) and their ratio (WHR), waist circumference to height ratio (WHT)) and blood pressure (BP) were obtained by standard methods. Blood samples (6 ml) were obtained for the determination of glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) by enzymatic methods while low density lipoprotein cholesterol (LDL-C) was calculated. Descriptive statistics, Chi-square test and ANOVA were among the analyses conducted. Results: 301 (56.4%) of traders studied were overweight (176, 33.0%) or obese (125, 23.4%) while 17 (3.4%) and 125 (40.4%) were underweight and normal weight respectively. The prevalence of MS and obesity were 87 (16.3%) and 125 (23.4%) respectively. There was significant association between obesity and MS (p < 0.05). Both MS and obesity were significantly associated with gender (p < 0.05). The prevalence of MS and obesity was higher in female (20.9%; 31.0%) than male traders (6.5%; 7.1%) respectively. The prevalence of MS increased from normal weight (8.3%) to overweight (18.8%) to obesity (28.8%). There were significantly higher differences in age, BP(systolic and diastolic), weight, BMI, WC, HC, WHT, WHR, and PBF but lower difference in height when overweight/obese groups were compared with normal weight group (p < 0.05). TC and LDL-C were significantly higher in only obese than normal weight traders. However, FPG, TG and HDL-C were similar in all groups (p >0.05). Conclusion: There is high prevalence of MS and obesity among Nigerian traders. Female gender, hypercholesterolemia, hypertension, increasing age, general and abdominal obesity appear to be important metabolic risk factors of CVD and not DM2 among Nigerian traders. Health care strategies for effective modulation of diet and lifestyle are needed urgently. In addition, screening programs for indices of MS in all Nigerians irrespective of BMI could be considered.
Inhibin B levels in relation to obesity measures and lipids in males with different numbers of metabolic syndrome components
(2016) Laniyan, D. O.; Charles-Davies, M. A.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Adebusuyi, J. R.; Hassan, O.; Ajobo, B. M.; Ebesunun, M. O.; Adigun, K.; Akinlade, K. S.; Okoli, S. U.; Arinola, O. G.; Agbedana, E. O.
Introduction: Defective spermatogenesis and metabolic syndrome affect 2-4% and 12.4% of males respectively. Deficient testosterone levels due to increased conversion of testosterone to oestradiol have been demonstrated in males with the metabolic syndrome (MS) with limited pituitary and leptin contribution. Defective spermatogenesis is thus implicated in males with MS but is controversial. Inhibin B is a marker of spermatogenesis. This study aims at evaluating inhibin B levels and their relationship with obesity measures and lipids in males with different number of MS components. Materials and Methods: This is a preliminary prospective study in which a total of 106 apparently healthy males (30, 30, 30 and 16 males with 0, 1, 2 and ≥3 components of metabolic syndrome (NMSC) respectively) aged 19-64 years were purposely selected. Blood pressure (BP) and obesity measures (including visceral adiposity index (VAI) and body mass index (BMI)) were obtained by standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides and high density lipoprotein cholesterol (HDLC) were determined by enzymatic methods while low density lipoprotein cholesterol (LDLC) and the lipid ratios (TG/HDLC, TC/HDLC, LDLC/HDLC) were calculated. Inhibin B was analysed by enzyme linked immunosorbent assay (RayBiotech, Inc. USA). Data analysed using analysis of variance (ANOVA) and multiple regressions were significant at P <.05. Results: Inhibin B decreased significantly in males with 0 to 2 NMSC (P <.05). However, inhibin levels between males with 0 and ≥3 NMSC were similar. Age and inhibin B levels were also similar among the different classes of BMI (P>0.05). Inhibin B related positively with HDLC and TC but negatively with VAI, LDLC and TC/HDLC. Conclusion: Reproductive function appears protected in Nigerian males with MS. However, improvement in HDLC, LDLC, TC levels, VAI and TC/HDLC may enhance fertility potential especially in males with one or two MS components, probably through dietary modulation and physical activity.
Leptin concentrations in African blacks with metabolic syndrome and Type 2 diabetes mellitus
(David Publishing, 2011) Fabian, U. A.; Charles-Davies, M. A.; Adebusuyi, J. R.; Ebesunun, M. O.; Ajobo, B. M.; Hassan, O. O.; Adigun, K.; Owolabi, M. O.; Oyewole, O. E.; Olaniyi, J. A.; Fasanmade, A. A.; Akinlade, K. S.; Arinola, O. G.; Agbedana, E. O.
Background: Mortality rate from metabolic/cardiometabolic syndromes (MS/CMS) and type 2 diabetes mellitus (DM2) are highly prevalent in African blacks known with higher mortality from cardiovascular diseases than caucasians. Leptin, a satiety-regulating hormone increases in obesity and is associated with cardiovascular risk and prediction of MS. This study is designed to evaluate leptin in Nigerians with MS and DM2 to assist in the early diagnosis and prevention of metabolic diseases. Methods: 136 participants (45 with MS, 47 with DM2 and 44 apparently healthy individuals (controls)) aged 18-80 years were included in a cohort study at the University College Hospital, Ibadan. Measures of adiposity-%body fat, body mass index (BMI), waist and hip circumferences (WC and HC respectively), waist to hip ratio (WHR), and blood pressure were obtained by standard methods. 10 ml of blood were obtained from each participant after an overnight fast (10-14 h) and analysed for leptin, total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), and glucose by standard methods while low density lipoprotein (LDL) was calculated. Data obtained were analysed statistically with SPSS software version 16.0. Results: Weight, BMI, WC, HC, WHR, %body fat, blood pressure, TG, LDL-C, and glucose were significantly higher while HDL-C was significantly lower in individuals with MS and DM2 compared with controls (p<0.039). Leptin levels were significantly higher in MS group and not in DM2 group when compared with controls (p=0.000). Leptin did not correlate with any of the biochemical indices (p>0.05) tested but correlated significantly with different measures of adiposity in all groups. Leptin correlated negatively but significantly with blood pressure in MS group only. Conclusion: Increases in leptin levels in both MS and DM2 groups might reflect adiposity. Observed high leptin levels in MS group might be a compensatory mechanism for maintenance of weight/fat loss and blood pressure. Its routine analysis may assist in assessing adiposity associated with MS and DM2 for probable prevention of metabolic diseases.
Male sexual dysfunction, leptin, pituitary and gonadal hormones in Nigerian males with metabolic syndrome and type 2 diabetes mellitus
(Avicenna Research Institute, 2016) Fabian, U. A.; Charles-Davies, M. A.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Owolabi, M. O.; Adebusuyi, J. R; Hassan, O. O.; Ajobo, B. M.; Ebesunun, M. O.; Adigun, K.; Akinlade, K. S.; Arinola, O. G.; Agbedana, E. O.
Background: Pituitary and gonadal dysfunctions resulting from increased adiposity leading to disturbances of sexual and reproductive functions have been reported in males with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2). The aim of this study was to evaluate sexual dysfunction, leptin, and reproductive hormones in Nigerian males with MS and DM2. Methods: Participants were 104 men (34 males with DM2, 17 men with MS and 53 men with normal body mass index (18.5-24.9 Kg/m2) without MS (controls)). The International Diabetes Federation (2005) criteria were used for MS diagnosis. Reproductive history, anthropometry, blood pressure (BP) and 10 ml fasting blood samples were obtained by standard methods. Fasting plasma glucose, total cholesterol, triglycerides and high density lipoprotein cholesterol were determined by enzymatic methods while low density lipoprotein cholesterol was calculated. Leptin, follicle stimulating hormone (FSH), luteinising hormone (LH), prolactin, testosterone and oestrogen were determined by enzyme immunoassay (leptin by Diagnostic Automation, Inc.; others by Immunometrics (UK) Ltd.) while oestrogen-testosterone ratio was calculated. Data analyzed using ANOVA, Chi square and multiple regression were statistically significant at p<0.05. Results: Testosterone was significantly lower in MS than controls while oestradiol and ETR were significantly higher in MS compared with controls and DM2 group (p<0.05). ETR significantly predicted testosterone in all groups (p<0.05). Significantly lower libido was observed in men in MS than controls and DM2 groups (p<0.05). Conclusion: Sexual and reproductive dysfunction may be related to increased conversion of testosterone to oestrogen in increased adipose mass in men with metabolic syndrome and type 2 diabetes mellitus.
Metabolic alterations in different stages of hypertension in an apparently healthy Nigerian population
(Hindawi Publishing Corporation, 2013) Charles-Davies, M. A.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Adebusuyi, J. R.; Hassan, O.; Ajobo, M. T.; Ebesunun, M. O.; Adigun, K.; Akinlade, K. S.; Fabian, U. A.; Popoola, O. O.; Rahamon, S. K.; Okunbolade, W.; Ogunlakin, M. A.; Arinola, O. G; Agbedana, E. O.
Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD risk measures were investigated in different stages of hypertension. 534 apparently healthy Nigerian traders aged 18–105 years were participants of a cohort study.The International Diabetes Federation (2005) and the National High Blood Pressure Education Program Coordinating Committee criteria were used for MS and HTN classifications, respectively. Anthropometric indices were obtained by standard methods. Levels of fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDLC) were determined by enzymatic methods, while low-density lipoprotein cholesterol (LDLC) was calculated. Data analysed statistically were significant at P < 0.05. 143 (26.8%), 197 (36.9%), and 194 (36.3%) of the traders had normotension, pre-HTN and HTN (stages 1 and 2), respectively. All indices tested except HDLC were significantly different among BP groups (P < 0.05).Waist to hip (WHR) and waist to height (WHT) ratios were significantly different between HTN groups (P < 0.05). HTN was associated with MS and female gender (P < 0.05). Metabolic alterations and significant HTN were observed. Treatment of the individual components of the syndrome and improvement of modifiable metabolic factors may be necessary to reduce MS and high BP.
Pragmatic Solutions for Stroke Recovery and Improved Quality of Life in Low- and Middle-Income Countries—A Systematic Review
(Frontiers Media S.A., 2020) Ekechukwu, E. N. D.; Olowoyo, P.; Nwankwo, K. O.; Olaleye, O. A.; Ogbodo V. E.; Hamzat, T. K.; Owolabi, M. O.
Background: Given the limited healthcare resources in low and middle income countries (LMICs), effective rehabilitation strategies that can be realistically adopted in such settings are required. Objective: A systematic review of literature was conducted to identify pragmatic solutions and outcomes capable of enhancing stroke recovery and quality of life of stroke survivors for low- and middle- income countries. Methods: PubMed, HINARI, and Directory of Open Access Journals databases were searched for published Randomized Controlled Trials (RCTs) till November 2018. Only completed trials published in English with non-pharmacological interventions on adult stroke survivors were included in the review while published protocols, pilot studies and feasibility analysis of trials were excluded. Obtained data were synthesized thematically and descriptively analyzed. Results: One thousand nine hundred and ninety six studies were identified while 347 (65.22% high quality) RCTs were found to be eligible for the review. The most commonly assessed variables (and outcome measure utility) were activities of daily living [75.79% of the studies, with Barthel Index (37.02%)], motor function [66.57%; with Fugl Meyer scale (71.88%)], and gait [31.12%; with 6min walk test (38.67%)]. Majority of the innovatively high technology interventions such as robot therapy (95.24%), virtual reality (94.44%), transcranial direct current stimulation (78.95%), transcranial magnetic stimulation (88.0%) and functional electrical stimulation (85.00%) were conducted in high income countries. Several traditional and low-cost interventions such as constraint-induced movement therapy (CIMT), resistant and aerobic exercises (R&AE), task-oriented therapy (TOT), body weight supported treadmill training (BWSTT) were reported to significantly contribute to the recovery of motor function, activity, participation, and improvement of quality of life after stroke. Conclusion: Several pragmatic, in terms of affordability, accessibility and utility, stroke rehabilitation solutions, and outcome measures that can be used in resource-limited settings were found to be effective in facilitating and enhancing post-stroke recovery and quality of life.
Predictors of weight reduction in a Nigerian family practice setting
(Ghana Medical Association, 2021) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Adebusoye, L. A.; Ogunniyi, A.
Objectives: This study identified the predictors of weight reduction among adult obese patients in a Family Practice Setting and developed a statistical model to predict weight reduction. Design: A prospective cohort design. Setting: The Family Practice Clinic, University College Hospital, Ibadan, Nigeria Participants and study tools: Obese adults were recruited into a three-month weight reduction program. Patient Information Leaflets were used for counselling, while questionnaires were administered to obtain socio-demographic and lifestyle factors. Potential predictors were assessed using the Multidimensional Scale of Perceived Social Support, Zung Depression Scale, Rosenberg Self-Esteem scale, Garner’s Eating Attitude Test-26 (EAT-26), 24-hour dietary recall and International Physical Activity Questionnaire-short form. Anthropometric indices, blood pressure and Fast-ing Lipid Profile were assessed. Descriptive and inferential statistics were used for analysis with a significance set at α0.05. Results: Most 99(76.2%) of the 130 participants achieved weight reduction and had a median weight change of -2.3kg (IQR-4, -0.5), with 66 (66.7%) out of 99 attaining the weight reduction target of 10%. The regression model showed predictors of weight reduction to be Total Cholesterol [TC] (p=0.01) and Low-Density Lipoprotein Cholesterol [LDL-C] (p=0.03). The statistical model derived for Weight reduction = 0.0028 (LDL-C) -0.029 (TC)-0.053 (EAT-26) +0.041(High-Density Lipoprotein Cholesterol). The proportion of variance of the model tested was R2 = 0.3928 (ad-justed R2 = 0.2106). Conclusion: Predictors of weight reduction among patients were eating attitude score, Total Cholesterol, Low-Density Lipid and High-Density Lipoprotein Cholesterol levels. A statistical model was developed for managing obesity among patients.
Prevalent components of metabolic syndrome and their correlates in apparently healthy individuals in Sub-Saharan Africa
(2014) Charles-Davies, M. A.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Adebusuyi, J. R.; Hassan, O.; Ajobo, M. T.; Ebesunun, M. O.; Adigun, K.; Akinlade, K. S.; Fabian, U. A.; Popoola, O. O.; Rahamon, S. K.; Okunbolade, W.; Ogunlakin, M. A.; Arinola, O. G.; Agbedana, E. O.
Aim: To assess the prevalent components of metabolic syndrome (MSC) and their related determinants of lipid metabolism in the Nigerian for early diagnosis, prevention and management of the metabolic syndrome (MS) and its associated diseases. Study Design: Cohort study. Place and Duration of Study: Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan between March and August 2010. Methodology: 534 apparently healthy Nigerian traders aged 18–105 years were participants of a cohort study. The IDF (2005) criteria was used for MS diagnosis. Anthropometric indices and blood pressure (BP) were obtained by standard methods. Fasting plasma glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDLC) were determined by enzymatic methods while low density lipoprotein cholesterol (LDLC) was calculated. Data analysed were statistically significant at P<0.05. Results: 60.1% of traders had 2 and 3MSC. 0.6%, 1.1% and 9.6% of traders had all 5MSC, ≥3MSC without elevated waist circumference (WC) and zero MSC respectively. Elevated WC, reduced HDLC and high BP were more frequent MSC representing 70.2%, 63.1% and 47.9% while FPG and TG were less frequent representing 11.2% and 2.2% of traders respectively. This pattern was similar in MS and non-MS groups. 25.3% of males and only 2.2% of females had no MSC. Reduced HDLC and elevated WC were the most frequent MSC in males and females respectively. All metabolic risk factors (MRF) except TC were significantly different in comparison between MS and non-MS groups as well as among traders with 0-5 MSC. WHR was the only parameter that correlated significantly with all MRF. Conclusion: Elevated waist circumference, reduced high density lipoprotein cholesterol, and high blood pressure may be prevalent metabolic syndrome components and important in managing metabolic syndrome in Nigeria. Regional specific cut-offs for these components for the African population is needed.
Sex hormones and their relationship with leptin and cardiovascular risk factors in pre and post-menopausal Nigerian women with metabolic syndrome
(2015) Fabian, U. A.; Charles-Davies, M. A.; Fasanmade, A. A.; Olaniyi, J. A.; Oyewole, O. E.; Owolabi, M. O.; Adebusuyi, J. R.; Hassan, O.; Ajobo, M. B.; Ebesunun, M. O.; Adigun, K.; Akinlade, K. S.; Arinola, O. G.; Agbedana, E. O.
Metabolic Syndrome (MS), which affects 33.1% of Nigerians, predisposing them to cardiovascular disease (CVD) risk, has been associated with the female gender. The cardioprotective effect of oestradiol against CVD is now controversial and was investigated in premenopausal with MS (PRMMS) and postmenopausal women with MS (POMMS). A total of 191 women (44 PRMMS, 126 POMMS and 21 premenopausal women without MS (PRM) (controls) with mean (s.d) age of 40.0 (6.9), 57.0 (8.8), 29.0 (6.8) years were participants of this study. Demography, blood pressure (BP), anthropometry, hormones, fasting plasma glucose (FPG) and lipids were obtained by standard methods. Data were significant at (P<.05). Age, parity, all anthropometric measures, FPG, leptin, ET ratio and FSH were significantly higher while HDLC, testosterone and prolactin were significantly lower in PRMMS compared with controls (P<.03). In comparison of POMMS with PRMMS, age, parity, WHR, systolic BP, TG, FSH and LH were significantly higher while body weight, HC, and leptin were lower in POMMS compared with PRMMS (P<.05). DBP positively predicted oestradiol in PRM only (P=.044) while oestradiol positively predicted testosterone in PRMMS only (P<.001). In POMMS only, DBP positively predicted testosterone; testosterone, ET ratio and FSH positively predicted oestradiol while LDLC and oestradiol positively predicted the ET ratio (P<.03). Metabolic syndrome may predispose both pre and postmenopausal women to the risk cardiovascular disease and type 2 diabetes mellitus. Oestradiol may protect against cardiovascular diseases in women without metabolic syndrome only.
Stroke Rehabilitation: Should Physiotherapy Intervention be Provided at a Primary Health Care Centre or the Patients’ Place of Domicile?
(Informa Healthcare, 2014) Olaleye, O. A.; Hamzat, T. K.; Owolabi, M. O.
"Purpose: This randomized controlled trial compared the outcomes of physiotherapy intervention on selected indices of recovery for stroke survivors treated at a primary health centre group (PHCG) with those treated in their respective places of domicile group (DG). Methods: Participants were 52 individuals comprising 24 males and 28 females who had suffered a stroke and were recently discharged from two inpatient health facilities in Ibadan, Nigeria. They were randomly assigned into either the PHCG (n=25) or DG (n = 27) and treated twice weekly for 10 consecutive weeks using a physiotherapy intervention protocol comprising a battery of task- specific exercises. The outcomes measured were motor function, balance and handicap assessed using the modified motor assessment scale (MMAS), short-form postural assessment scale for stroke (SF-PASS) and reintegration to normal living index (RNLI), respectively, as well as walking speed which was assessed using a standard technique. Results: Between-group comparison using the General Linear Model revealed no statistically significant difference in both the pre- and post-intervention scores of the two groups on the MMAS, SF-PASS, RNLI and walking speed in both PHCG and DG (p>0.05). However, within-group comparison yielded a statistically significant difference in each of the indices of stroke recovery measured across the 10-week period in both groups. Conclusion: Physiotherapy intervention at the primary health care centre and respective homes of stroke survivors similarly improved clinical outcomes. Treatment at any of these locations may enhance access to physiotherapy after stroke in a low- income community like Nigeria. "
Weight control, alcohol reduction, smoking cessation, health promotion, exercise and diet (WASHED)’: a mnemonic for lifestyle modification in obesity
(Department of Family Medicine, University College Hospital, Ibadan, 2015) Ogunbode, A. M.; Owolabi, M. O.; Ogunniyi, A.; Ogunbode, O. O.
What’s in your hands? A systematic review of dietary assessment methods and estimation of food sizes in a Primary Care Clinic
(Wolters Kluwer - Medknow, 2018) Ogunbode, A. M.; Owolabi, M. O.; Ogunbode, O. O.; Ogunniyi, A.
Introduction: Many patients with non-communicable diseases such as obesity are attended to in Family Practice Clinics where quick dietary assessment along with estimation of food sizes as part of lifestyle modification and appropriate intervention could be offered. We performed a systematic review to determine the dietary assessment methods with the best evidence that can be employed in a Family Practice Clinic. Methods: Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines were used to conduct a systematic review of PubMed, Google, and Google Scholar databases from 1992 to 2017. Results: We found 730 original research articles, case–control studies, review articles, proceedings, transactions, and textbooks. Thirty-seven articles were selected out of which two were secondary data, 12 were review articles, 10 were descriptive surveys, and one was a prospective cohort study. There were two randomized controlled trials, two mixed study designs, one working paper, and seven guides. Food portion size estimation using household objects and the hand guide, then the food pyramid guide along with the food-sized plate intervention was documented. Conclusion: In view of the busy nature of Family Practice Clinics in several countries, in performing dietary assessment, food portions can be estimated using household measures and the hand portion guide. The pyramid guide and the portion-sized plate can then be used for intervention.