Browsing by Author "Uvere, E."

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Phenotyping stroke in Sub-Saharan Africa: stroke investigative research and education network (SIREN) phenomics protocol
(Karger Publishers, 2015) Akpalu, A.; Sarfo, F. S.; Ovbiagele, B.; Akinyemi, R.; Gebregziabher, M.; Obiako, R.; Owolabi, L.; Sagoe, K.; Jenkins, C.; Arulogun, O.; Adamu, S.; Appiah, L. T.; Adadey, M. A.; Agyekum, F.; Quansah, J. A.; Mensah, Y. B.; Adeoye, A. M.; Singh, A.; Tosin, A. O.; Ohifemen, O.; Sani, A. A.; Tabi-Ajayi, E.; Phillip, I. O.; Isah, S. Y.; Tabari, N. A.; Mande, A.; Agunloye, A. M.; Ogbole, G. I.; Akinyemi, J. O.; Akpa, O. M.; Laryea, R.; Melikam, S. E.; Adinku, D.; Uvere, E.; Burkett, N.-S.; Adekunle, G. F.; Kehinde, S. I.; Azuh, P. C.; Dambatta, A. H.; Ishaq, N. A.; Arnett, D.
Background: As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in Sub-Saharan Africa (SSA), where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, traditional and emerging risk factors for stroke in SSA have not been well characterized, thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics for brain research. Methods: SIREN is a transnational, multicentre, hospital and community-based study involving 3,000 cases and 3,000 controls recruited from 8 sites in Ghana and Nigeria. Cases will be hospital-based patients with first stroke within 10 days of onset in whom neurovascular imaging will be performed. Etiological and topographical stroke sub types will be documented for all cases. Controls will be hospital- and community-based participants, matched to cases on the basis of gender, ethnicity, and age (±5 years). Information will be collected on known and proposed emerging risk factors for stroke. Study Significance: SIREN is the largest study of stroke in Africa to date. It is anticipated that it will shed light on the phenotypic characteristics and risk factors of stroke and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of stroke on the sub-continent.
Substance Use and Perceived Consequences on Health and Safety among Commercial Motorcyclists in Ibadan North Local Government, Ibadan, Nigeria
(Science domain International, 2014) Ndikom, C. M.; Ndikom O. B. C.; Uvere, E.
Introduction: Motorcycling is a globalized mode of transport patronized by many road users especially in Nigeria. Although, fraught with negative health outcomes. This study sought to access the perceived consequences of substance use on health and safety among commercial motorcyclists in Ibadan, Nigeria. Design and Method: Using a cross-sectional survey design, registered and consenting eighty commercial motorcyclists were recruited. A 39 item, interviewer-administered questionnaire containing motorcyclists’ demographic characteristics, perceived consequence of substance use, behaviour towards substance use and consequences of substance use was used to obtain information. Collected data was analyzed at p≤0.05 of significance. Results: The respondents were mainly within 30-39 years (36.3%); previously traders (42.5%) and have attained secondary school level of education (45.0%). Though, 57.5% of the respondents positively affirmed the ability of an individual under the influence of alcohol to cause accident, 46.3% of them hold the belief that it is good for mood modification and did not affect health negatively (70%). Up to 36.2% of the respondents agreed to have used substances while driving. Enhancement of visibility while driving (51.3%), relaxation (47.5%) and assists in forgetting problems (42.5%) were reasons given by motorcyclists for this. Fifty percent of the motorcyclists have been involved in a fatal accident. There no significant association between educational level and perception about substance use at p=0.258 but association between perception on substance use and age of respondents was significant at p=0.05. The Perception and Behavior of motorcyclists’ Riders were significantly different at p= 0.04. Conclusion: Although, the respondents know that substance use had some negative consequences, yet many still indulged in it even when on duty. Positive behavioural change interventions should be implemented among motorcyclists.
Unraveling the ethical, legal, and social implications of neurobiobanking and stroke genomic research in Africa: a studyprotocol of the African neurobiobankfor precision stroke medicine ELSI project
(Sage Publications, 2020) Akinyemi, R. O.; Jenkins, C.; Nichols, M.; Singh, A.; Wahab, K.; Akpalu, A.; Sarfo, F. S.; Owolabi, L. F.; Obiako, R.; Akinyemi, J.; Ojebuyi, B.; Adigun, M.; Musbahu, R.; Bello, A.; Titiloye, M.; Calys-Tagoe, B.; Ogunronbi, M.; Uvere, E.; Laryea, R.; Fakunle, A.; Adeleye, O.; Olorunsogbon, O.; Ojo, A.; Adesina, D.; Mensah, N.; Oguike, W.; Coleman, N.; Mande, A.; Uthman, M.; Kalaria, R. N.; Jegede, A.; Owolabi, M.; Ovbiagele, B.; Arulogun, O.
The ethical, legal, and social implications (ELSI) of emerging neurobiobanks and data resources are unclear in an African scientific landscape with unique cultural, linguistic, and belief systems. The overarching goal of the African Neurobiobank for Precision Stroke Medicine–—ELSI Project is to identify, examine, and develop novel approaches to address ELSI issues of biobanking and stroke genomic research in sub-Saharan Africa (SSA). To accomplish the goal we will (1) explore knowledge, attitude, perceptions, barriers, and facilitators influencing ELSI issues related to biobanking and stroke genomic research; (2) use information obtained to craft a community intervention program focused on ELSI issues; and (3) build capacity and careers related to genomics and biobanking for effective client/community engagement while enhancing regulatory, governance, and implementation competences in biobanking science in SSA. A community-based participatory research and mixed-methodological approach, focused on various levels of the social ecological model, will be used to identify and examine relevant ELSI issues. Contextual intervention tools, platforms, and practices will be developed to enhance community understanding and participation in stroke biobanking and genomics research activities while facilitating enduring trust, and equitable and fair utilization of biobanking resources for genetic and trans-omics research. A concurrent capacity building program related to genetic counseling and biobanking will be implemented for early career researchers. The huge potential for neurobiobanking and genomics research in Africa to advance precision medicine applicable to stroke and other neurological disorders requires addressing ELSI challenges while building sustainable research, career, and regulatory capacities in trans-omics and biobanking science.