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    Curcumin and Kolaviron Ameliorate Di-n-Butylphthalate-Induced Testicular Damage in Rats
    (Nordic Pharmacological Society, 2007) Farombi, E. O.; Abarikwu, S. O.; Adedara, I. A.; Oyeyemi, M. O.
    The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the rhizome, Curcuma longa L.) on the di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration of DBP to rats at a dose of 2 g/kg for 9 days significantly decreased the relative testicular weights compared to the controls, while the weights of other organs remained unaffected. Curcumin or kolaviron did not affect all the organ weights of the animals. While only DBP treatment significantly increased the testicular malondialdehyde level and gamma-glutamyl transferase activity (γ-GT), it markedly decreased glutathione level, the testicular catalase, glucose-6-phosphate dehydrogenase, superoxide dismutase, sperm γ -GT activities and serum testosterone level compared to the control group. Data on cauda epididymal sperm count and live/dead ratio were not significantly affected in the DBPtreated rats. Alone, DBP treatment resulted in a 66% decrease in spermatozoa motility and a 77% increase in abnormal spermatozoa in comparison to control. DBP-treated rats showed marked degeneration of the seminiferous tubules with necrosis and defoliation of spermatocytes. The DBP-induced injuries in biochemical, spermatological parameters and histological structure of testis were recovered by treatment with kolaviron or curcumin. The pattern in the behaviour of these compounds might be correlated with their structural variations. Our results indicate that kolaviron and curcumin protect against testicular oxidative damage induced by DBP. The chemoprotective effects of these compounds may be due to their intrinsic antioxidant properties and as such may prove useful in combating phthalate-induced reproductive toxicity.
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    Influence of quercetin on haematological indices and biomarkers of oxidative stress in the serum of rats exposed to atrazine
    (College of Medicine, University of Ibadan, 2010) Abarikwu, S. O.; Adedara, I. A.; Farombi, E. O.
    The study was carried out to compare thè effects of quercetin (QT) at doses of 5mg/kg (QQ and lOmg/kg (Q|0) against thè hematological toxicity and oxidative stress caused by atrazine (ATR). Male rats were oraily gavaged with ATR at a dose of 120mg/kg for 16 days. Erythropenia, leucopenia was observed in ATR treated rats. Other hematological variables such as packed celi volume (PCV), hemoglobin concentration (HGB), mean celi hemoglobin concentration (MCHC), mean corpuscular volume (MCV), neulrophils (NEU), lymphocytes (LYM) and blood platelet (PLT) showed no significant change with respect to thè control values. The activities of thè antioxidant defense molecules including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione (GSH) were decreased; malondialdehyde (MDA) level increased but catalase (CAT) activity showed no change.Co-administration of Q5 did not prevent thè oxidative stress and thè fiematological alterations caused by ATR. In these groups of animals, thè values of PLT and NEUT were increased while LYM decreased indicating more pronounce hematological changes. The changes in both thè biochemical and hematological variables were noi malized to thè control values on co-administration of Ql0. We suggest that thè antioxidant activities of QT al a doses of lOmg/kg could be responsible for its protecti ve effects against ATR-induced oxidative stress and hematological toxicity.