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Author: search.filters.author.Farombi E.O.

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    Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish
    (Elsevier Inc., 2022) Adedara, I. A. || || || || || || || || || || ||; Souza, T. P.; Canzian, J.; Olabiyi, A. A.; Borba, J. V.; Biasuz, E.; Sabadin, G. R.; Goncalves, F. L. S.; Costa, F. V.; Schetinger, M. R. C.; Farombi E.O.; Rosemberg, D. B.
    Perfluorooctanoic acid (PFOA) is a contaminant of global concern owing to its prevalent occurrence in aquatic and terrestrial environments with potential hazardous impact on living organisms. Here, we investigated the influence of realistic environmental concentrations of PFOA (0, 0.25, 0.5, or 1.0 mg/L) on relevant behaviors of adult zebrafish (Danio rerio) (e.g., exploration to novelty, social preference, and aggression) and the possible role of PFOA in modulating cholinergic and purinergic signaling in the brain after exposure for 7 consecutive days. PFOA significantly increased geotaxis as well as reduced vertical exploration (a behavioral endpoint for anxiety), and increased the frequency and duration of aggressive episodes without affecting their social preference. Exposure to PFOA did not affect ADP hydrolysis, whereas ATP and AMP hydrolysis were significantly increased at the highest concentration tested. However, AChE activity was markedly decreased in all PFOA-exposed groups when compared with control. In conclusion, PFOA induces aggression and anxiety-like behavior in adult zebrafish and modulates both cholinergic and purinergic signaling biomarkers. These novel data can provide valuable insights into possible health threats related to human activities, demonstrating the utility of adult zebrafish to elucidate how PFOA affects neurobehavioral responses in aquatic organisms.
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    Influence of Atrazine and Diclofenac Co-exposure on Hypothalamic-Pituitary-Testicular Axis Function in Rats
    (2021) Adedara I. A.|| || || || ||; Godswill U. S.; Amorha C. C.; Sule, J.; Mike M. A.; Farombi E.O.
    Humans and animals are commonly exposed to numerous chemicals through diverse sources causing unpredictable real-life health effects. This study evaluated the influence of joint exposure to the herbicide atrazine (ATZ) and the NSAID diclofenac (DCF) on the hypothalamic-pituitary-testicular axis function in pubertal rats. The animals were jointly exposed to ATZ (20 and 40 mg/kg body weight) and DCF (10 and 20 mg/kg body weight) for 42 days. In comparison with individual exposures, the current data illustrated that combined exposure to ATZ and DCF exacerbated the reductions in follicle stimulating hormone (FSH), luteinizing hormone (LH), serum and intra-testicular testosterone levels with testosterone/LH ratio. Additionally, co- exposure to ATZ and DCF worsened the sperm quality and quantity with marked disruption in the testicular function marker enzymes activities. The diminution in the epididymal, testicular and hypothalamic antioxidant defense mechanisms was intensified in animals co-exposed to ATZ and DCF. Moreover, the induction of reactive oxygen and nitrogen species, lipid peroxidation, inflammatory stress and histopathological lesions in the epididymal, testicular and hypothalamic tissues was intensified in co-exposed animals. These data accentuate the possible male reproductive dysfunction related to ATZ and DCF co-exposure in mammals and, by extension, provide useful insights into the public health threats associated with combined exposure to pesticides and pharmaceuticals.