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Effect of ethanol extract of Irvingia Gabonensis (Aubrey Lecomte Ex O. Rorke) baill. (Irvingiaceae) seeds on diet induced obesity in Wistar Rats
(Istanbul Medipol University, 2021) Ajayi, T. O.; Bakre, A. G.; Akintayo, T. C.; Bamigboye, O. O.
Obesity is a chronic condition associated with high morbidity and mortality rates. Its comorbidities include cancer, diabetes mellitus, and cardiovascular diseases. Traditional medicines have found increasing use due to cost effectiveness and mini mal side effects. This study evaluated the Anti-obesity effect of ethanolic extract of Irvingia gabonensis seeds. Wistar rats were divided into control and treatment groups. Untreated group I on normal diet (negative control), untreated group II on high fat diet (HFD) and 10 mL/Kg Tween 80 (positive control), extract treated groups III-V (50, 100 and 200 mg/Kg) on HFD. Orlistat treated group VI (200 mg/Kg) on HFD (standard). Body mass index (BMI), weight of abdominal fat, cholesterol levels and hepatic enzymes were evaluated after 12 days of treatment. Body mass index (BMI) and abdominal fat of (treatment groups) reduced. How ever, the seed extract and orlistat did not significantly increase liver enzymes. Conclusion: Irvingia gabonensis seed extract showed anti-obesity properties.
Comparative total phenolic content, anti-lipase and antioxidant activities of two Nigerian aframomum species
(Nigerian Society of Pharmacognosy, 2016) Ajayi, T. O.; Moody, J. O.; Abiose, I. M.; Ezeoku, N. J.
The anti-obesity drug development is presently not a bright story. So far, drugs reported to be effective have stimulated controversies due to side effects they elicit. Obesity and its co-morbidities continue however to constitute major problems in both developed and developing countries. This has resulted in a continuous search for novel, cost-effective, safe and potent alternatives. This study investigated the ethanolic extracts of two Nigerian Aframomum species for their anti-lipase and anti-oxidant activities as well as estimates of their polyphenol contents. Lipase activity was determined using glyceryltrioleate emulsion as a substrate and measuring the release rate of oleic acid from it. Percentage inhibition of lipase by the methanolic extracts of plants was determined spectrophotometrically at T€ and Tƒ € (30 minutes after incubation at 37ÚC). DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity of the extracts and that of gallic acid as control was measured using the stable radical DPPH method and absorbance at 515 nm using a spectrophotometer. The IC50 (half-maximal inhibitory concentration) value was calculated by linear regression analysis and the total phenolic content was determined by the Folin-Ciocalteau method at 765 nm. The standard curve was prepared by solutions of Gallic acid in methanol: water (50:50, v/v). Total phenol values are expressed in terms of Gallic acid equivalent (w/w of dry mass). Aframomum melegueta exhibited the highest phenolic content of 60.4 ± 2.36 mgGAE/g, a percentage antioxidant activity of 86.6 % at 200µg/ml and percentage lipase inhibition of 89% at 1mg/ml while Aframomum danielli revealed a total phenolic content of33.3 ± 2.71mgGAE/g, a percentage antioxidant activity of 77.3% at 200µg/ml and percentage lipase inhibition of 73% at 1 mg/ml. The result provides some justifications for the use of these plants in ethno-medicine for the management of obesity. The species exhibited properties that are beneficial to health and therefore could find use as an alternative and/or complementary strategy in managing associated co-morbidities of obesity, and also as possible template for future anti-obesity drug development.
Ethnobotanical survey of plants used in the management of obesity in Ibadan, south-western Nigeria
(African Journals Online, 2015) Ajayi, T. O.; Moody, J. O.
Background: Until recent times, being obese was considered to be an evidence of wealth in the South-Western part of Nigeria. As a result of a combination of wrong attitudes, ignorance and carefree lifestyle, a sizeable percentage of the population has become predisposed to obesity an emerging problem in developing economies of the world. Objective: To identify and document medicinal plants used in ethno-medical management of obesity in selected rural and urban communities within Ibadan metropolis. This is with the aim of contributing to a database of plants for future systematic biological and chemical evaluation for possible source of anti-obesity agents and drug leads. Materials and methods: An inventory of plant species/natural remedies used in folk medicine to manage obesity in two Local Government Areas of Oyo State was undertaken. Interviews using semi-structured questionnaires and open-ended conversations were conducted among eighty (80) respondents (30% men and 70% women) aged 25 years and above to obtain relevant information.. Results: A total of fifteen (15) plants belonging to twelve (12) genera and twelve (12) families were identified. The usage profiles of the plants were quantified by the quotation frequency/mention index. Respondents from the urban rely more on finished products from local and foreign blends which are mostly multi-component remedies. Conclusion: The study revealed that Ibadan is a rich source of plants indicated in management of obesity. More scientific work especially biological studies are needed to ascertain the efficacy, toxicity, safety and appropriate dosage regimen of these ethno-medicinal remedies.

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