scholarly works Pharmaceutics and Industrial Pharmacy

Permanent URI for this collectionhttps://repository.ui.edu.ng/handle/123456789/560

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Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations.
(Springer, 2016-05) Ajala, T. O; Akin-Ajani, O. D; Ihuoma-Chidi, C.; Odeku, O. A
Chrysophyllum mucilage obtained from the fruit of Chrysophyllum albidum (Family Sapotaceae) hasbeen characterised and evaluated as a binding agent in comparison with methylcellulose in paracetamol tabletformulations. Chrysophyllum mucilage was characterized using elemental and proximate analyses as well as material properties. The Heckel and Kawakita plots were used to assess the compressional properties and the tablet properties were evaluated using tensile strength, friability, disintegration and dissolution times. The results showed the presence of calcium, magnesium, potassium, sodium, manganese, iron, copper, zinc and absence of heavy metals from the mucilage. The mucilage exhibited excellent flow and swelling properties, but poor water solubility. The viscosity of chrysophyllum mucilage increased with decrease in temperature in a similar manner with methylcellulose. C. albidum mucilage when used as a binder in paracetamol tablet formulation induced faster onset of plastic deformation and higher amount of total plastic deformation than methylcellulose. The results of the tablet properties showed that the tensile strength, disintegration and dissolution times, increased with increase in binder concentration while friability decreased. Tablets containing chrysophyllum mucilage as binder also had lower tensile strength, disintegration and dissolution times but higher friability values than those containing methylcellulose. However, tablets containing chrysophyllum mucilage at low concentrations conformed to pharmacopeial standard on disintegration indicating its potential usefulness as binder for immediate release tablets. Thus, C. albidum mucilage could be used as an alternative binding agent in pharmaceutical tablets
Date Mucilage as Co-Polymer in Metformin-loaded Microbeads for Controlled Release
(Natural Product Research Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria, 2019) Akin-Ajani, O. D; Odeku O. A.; Babalola Y.
The World Health Organization (WHO) has recognized the use of rectal preparations for certain indications in children as an alternative to parenteral. However, challenges of stability in tropical countries have limited its application. Furthermore, adverse effects arise in the use of some excipients in infants and neonates. In this study, paediatric paracetamol suppositories using two plant-derived fats - shea butter and dika fat - and their combination as suppository bases in comparison with cocoa butter were formulated. Shea butter and dika fat were purified and characterised using acid, iodine and saponification values, refractive index and relative density. Paracetamol suppositories were formulated by fusion method and evaluated using appearance, weight uniformity, melting point range, solidification point, crushing strength, disintegration time and dissolution test. Physicochemical properties showed shea butter and dika fat as stable with minimal susceptibility to oxidation with melting point ranges of 32 - 35C and 37 - 39C respectively. Base mixtures yielded melting point ranges of 32 - 39C. The suppositories had crushing strengths  31 N and disintegration times ranged between 3 - 21 min. Paracetamol release from the single bases ranked cocoa butter >dika fat > shea butter. Paediatric paracetamol suppositories using these plant-derived fats compared well with cocoa butter. Paracetamol suppositories with mixtures of either shea butter or dika fat with cocoa butter had superior release properties compared to cocoa butter alone. Thus, could serve as an alternative to cocoa butter in the formulation of suppositories.
Development of directly compressible excipients from Phoenix dactylifera (Date) mucilage and microcrystalline cellulose using co-processing techniques
(2018) Akin-Ajani, O. D; Ajala, T. O; Okoli, U. M.; Okonta, O
The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole. Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used in the direct-compression of metronidazole tablets. The shape and surface morphology of the particles of date mucilage (DAM) and co-processed excipients were generally granular, rough and irregular. There was a significant improvement in the disintegration of tablets prepared using the coprocessed excipients in comparison to that prepared using DAM alone. The disintegration time for tablets prepared using co-fused excipients was lower than that of co-grinded additives although the differences were not significant (p > 0.05). Generally, the co-processed excipients improved the mechanical and disintegration properties of the tablets produced compared to tablets prepared using DAM alone and could be further developed as direct compression excipients
The gelling properties of Dillenia indica mucilage in benzyl benzoate emulgel formulations
(University of São Paulo, 2020) Ajala, T. O.; Eraga, S.; Akin-Ajani, O. D
The objective of the study was to evaluate the gelling properties of Dillenia indica mucilage in benzyl benzoate emulgel formulation. Mucilage was extracted from the fruits of Dillenia indica using established methods and characterized by rheology and swelling. Emulsion (F1) was prepared using the continental emulsification method. Gelling agents (2 %w /v) were prepared by dispersing in distilled water with constant stirring at a moderate speed usinga magnetic stirrer. F1 was added to the gel (0-75 %w /w) to obtain emulgel formulations and evaluated using viscosity, globule size, pH, release profiles and kinetic modeling. Data were expressed as mean ± SD, and similarity factor (f2) was used to compare all formulations. Formulation viscosity was significantly higher with carbopol than with Dillenia; globule sizes increased with concentration of gelling agents, and pH reduced as the concentration of Dillenia increased. All formulations showed controlled release properties with t80 ranging between 114 and 660 min. The release was governed by Korsmeyer-Peppas model. Formulation F5 prepared with 50 % Dillenia showed highest similarity to F4 prepared with 75 %w /w carbopol. Dillenia indica demonstrated acceptable gelling properties comparable with that of carbopol and could be improved for use in emulgel formulations.