Pathology
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Item Secondary ovarian neoplasms in a tertiary hospital in South-Western Nigeria(Association of Resident Doctors, University College Hospital, Ibadan, Nigeria, 2019) Ajani, M. A.; Iyapo, O.; Salami, A.; Okolo, C. A.Background: The ovary is a common site of involvement for metastases constituting 5-30% of all malignant ovarian neoplasms. Over half of these tumours are bilateral. The commonest sources are stomach, large bowel, appendix, breast, uterus (corpus and cervix) and lung. Aim: The aim of this study was to determine the histopathological pattern of metastases to the ovary at the University College Hospital, Ibadan, South western Nigeria. Material and Methods: This was a retrospective study. All histologically confirmed cases of metastases to the ovary from the records and files of the Department of Pathology, University College Hospital (UCH), Ibadan between January 1991 and June 2013 were used for the study. These were cases diagnosed following total abdominal hysterectomy, total abdominal hystero-salpingo oophorectomy, bilateral salpingo-oophorectomy, omentectomy, and multiple peritoneal biopsies and post-mortems at the University College Hospital between January 1991 and June 2013. Cases with inadequate clinical data and whose blocks and or slides could not be retrieved were excluded from the study. The data obtained were analysed using the Statistical Package for Social Sciences version 20 Results: There were 46 cases of metastases to the ovary constituting 5.3% of total ovarian neoplasms. Thirty (63.9%) cases were metastatic carcinomas with the affected patients’ age range of 20-79 years, and peak incidence within the age group of 30-39 years. Nineteen out of 30 cases of metastatic carcinomas were from adenocarcinoma of colon, 6 cases were from the gastric carcinoma while the remaining five cases were from the squamous cell carcinoma of the uterine cervix. Fifteen (31.9%) cases of Burkitt Lymphoma were found with patients with age range of 0-39 years, and the peak age of occurrence at the 2nd decade. The only case of metastatic Malignant Mixed Mullerian Tumour and metastatic Leiomyosarcoma were found in the 3rd and 4th decades of life respectively Conclusion: This study has shown that metastases to the ovary occur in younger age groups in our environment. Therefore this study emphasizes that in young females with ovarian masses, the likelihood of metastatic tumours should not be discarded because, correct and precise diagnosis of secondary ovarian malignancy is critical as it has significant implication on the patients’ choice of management and prognosis.Item Histopathological pattern of primary ovarian neoplasms in South Western Nigeria.(Association of Resident Doctors of Jos University Teaching HospitalAssociation of Resident Doctors of Jos University Teaching Hospital, 2016) Ajani, M. A.; Aramide, K. O.; Salami, A.; Okolo, C. A.Background: Ovarian tumours are common form s o f neoplasms in women. This study aims to determine the histopathological pattern o f primary ovarian neoplasms in South-western Nigeria. Method: A retrospective study was undertaken to review the histopathology reports o f all primary ovarian neoplasm specimens submitted to the Department o f Pathology, University College Hospital, Ibadan from January 1991 to June 2013. Patients'biodata were extractedfrom the requestforms and surgical day books. Results: There were 821 cases o f primary ovarian neoplasms. 359 (43.7%) cases were surface epithelial neoplasms which were found in patients with age range 10-89 years. Three hundred and thirteen (38%) cases o f germ cell tumour were found in patients with age range 0-70 years. One hundred andforty-six (17.8%) cases ofsex cord stromal tumour werefound in patients with age range 0-99 years. Mature Cystic Teratoma was the most common (54.7%) among benign ovarian neoplasms with 20-29 years being the age range with highest tumours while serous cystadenocarcinoma was the most common (33.2%) primary malignant ovarian neoplasms with 50-59years being the age range with highest tumours. Conclusion: Surface epithelial tumours were the most common ovarian neoplasmfollowed by germ cell tumours. This pattern is observed in most parts of Nigeria, some African and Asian countries, and in the Western world.Item Childhood ovarian neoplasms in Ibadan, South‑western Nigeria.(Wolters Kluwer - Medknow, 2016) Ajani, M. A.; Aramide, K. O.; Ajani, T. A.; Salami, A. A.; Okolo, C. A.Childhood ovarian neoplasms are very rare. Little information is available on the relative pattern and frequency of these tumors in Nigerian children. Earlier study done in Ibadan involved ovarian neoplasms in children and adolescents. The aim of this study is to review cases of ovarian neoplasms in childrenMaterials and Methods: This was a retrospective study. Twenty four cases of childhood ovarian neoplasms were seen in patientsResults: Childhood ovarian neoplasms accounted for 2.8% of all cases of ovarian tumors seen in this period. Fourteen (58.3%) cases of childhood ovarian neoplasms were benign, and 10 (41.7%) were malignant. Mature cystic teratoma occurring in 13 (54.2%) was the most common childhood ovarian neoplasm and was most prevalent between 10 and 14 years of age. Burkitt lymphoma was the most common 4 (40%) malignant childhood ovarian tumor and prevalent between 5 and 14 years of age. Conclusion: Mature cystic teratoma remains the single most common childhood ovarian neoplasms, and Burkitt’s lymphoma is the most malignant childhood ovarian tumor in Ibadan, South western Nigeria.