Medicine

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Author: search.filters.author.Ojji D.B.

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    Pattern of prescription of anti-hypertensive medications in a tertiary health care facility in Abuja, Nigeria.
    (2013) Ojji D.B.; Ajayi S.O.; Mamven M.H.; Alfa J.; Albertino D.
    Introduction: Marked changes have been made in the pharmacotherapy of hypertension over the years. In sub-Saharan Africa, hypertension pharmacotherapy is often thought to include only thiazide diuretics, beta blockers and centrally acting medications and, it is unclear if and how often calcium channel blockers, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are used. Objective: To examine the anti-hypertensive prescription pattern in a tertiary health centre in Nigeria to determine how it conforms to current guidelines. Method: 590 newly diagnosed hypertensive patients presenting at the Cardiology Unit of University of Abuja Teaching Hospital over a three-year period were studied. Result: Calcium channel blockers were the most frequently prescribed anti-hypertensive medications (66.9% of all cases) and centrally acting medications were prescribed in only 5.01% of cases. Single-pill combination either alone or in combination with other antihypertensive medications were prescribed in 17.3% cases. Of these, calcium channel blocker-based combinations constituted the most frequently used multiple drug combinations. 94.6% of the patients required more than one medication for blood pressure control. Conclusion: Anti-hypertensive pharmacotherapy in Abuja, Nigeria, compares favorably with the current recommendations in the prescription pattern of anti-hypertensive medications. (Ethn Dis. 2013;23[4]:480–483)
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    Crossed fused renal ectopia presenting as recurrent lower abdominal pain and urinary tract infection
    (2013) Ajayi S.O.; Mamven M.H.; Tabari, A.; Ojji D.B.; Ibrahim A.
    Background: Crossed fused renal ectopia is a relatively rare condition which may remain undiagnosed for a long time. Renal function is usually preserved. It usually involves the left kidney. It is usually associated with mal-rotation, and may be a cause of urinary tract infection, hydronephrosis and renal calculi. Material and method: We report a case of a 15- year old boy who was referred to our clinic with complaints of abdominal pain, and an ultrasound report of “absent right kidney”. Results: Urine examination indicated a partially treated infection, but the tests of kidney functions were normal. Intravenous urography confirmed crossed fused renal ectopia, and a flush aortogram showed two anomalous right renal arteries arising from the left side of aorta. Conclusion: An “absent” kidney in its normal location should prompt further investigations. Recurrent chronic lower abdominal pain and urinary tract infection in a young person may be due to congenital renal abnormality. Evaluation of persistent urinary abnormalities in a child should include screening for congenital abnormalities.
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    Prevalence of metabolic syndrome among hypertensive subjects in abuja, Nigeria
    (2012) Ojji D.B.; Ajayi, S.O.; Mamven, M.H.; Alabi P.
    Background: It is well known that factors like high blood pressure, hyperglycemia, dyslipidemia, obesity and hyperuricemia tend to cluster together giving rise to what is called metabolic syndrome. In spite of the high prevalence of hypertension in Nigeria, there is a dearth of data describing the prevalence of metabolic syndrome in Nigerian hypertensive patients. We therefore set out to look at the prevalence of metabolic syndrome in hypertensive patients presenting to the cardiology clinic of a tertiary institution in Abuja, Nigeria. Methods: Metabolic syndrome was defined in patients according to the World Health Organisation’s definition. Results: Of the 362 patients studied, 56.9% were male and 43.1% were female. The mean age was 51.80 6 11.63 years, mean duration of hypertension was 8.90 6 3.95 years, mean body mass index was 29.36 6 6.12 kg/m2 and mean arterial blood pressure was 110.28 6 18.17 mm Hg. Overall, 13.0% of the study population had metabolic syndrome; 16.7% of females and 10.2% of males. Conclusion: The prevalence of metabolic syndrome among hypertensive patients in Abuja, Nigeria is comparable to rates observed in some general populations in Europe. This might imply the epidemiological transition in disease pattern already being experienced in many parts of sub-Saharan Africa.