Antimicrobial activity of Pseudocedrela kotschyi Schw. Hams (Meliaceae) and Longrich branded toothpaste on Streptococcus mutans from dental caries

Abstract

Background: Oral health has a significant impact on overall quality of human life. The rising prevalence of dental caries, demand for effective and cost-efficient treatment products. Objective: This study determined the antimicrobial activities of crude aqueous and ethanol extracts of Pseudocederalla kotschyi and Longrich branded toothpastes on isolates of Streptococcus mutans from dental caries. Methods: Fifteen (15) Isolates of biochemically confirmed Streptococcus mutans were challenged with aqueous and methanol extract of Pseudocedrela kotschyi using broth dilution method to determine their minimum inhibitory concentration and minimum bactericidal concentrations of the aqueous extract of Longrich branded toothpastes. The chewing sticks extract were also screened for secondary metabolite using standard methods. Results: The aqueous extract of Pseudocedrela kotschyi and Longrich branded toothpaste elicited minimum inhibitory concentration range from 25 pg/mL - 100 pg/mL while the minimum inhibitory concentration of 3 pg/mL -100 pg/mL and 25pg/mL - 100 pg/mL were recorded for Pseudocedrala kotschyi and Longrich branded toothpaste respectively. Each of the sample investigated elicited antimicrobial activity but methanol extract of Pseudocedrela kotschyiv/as remarkably higherthan the antimicrobial potency of the Longrich branded toothpastes. Conclusion: Although, the aqueous extract of the Longrich branded toothpasteexhibited antimicrobial activity,the methanol extracts of Pseudocedrela kotschyi holds the potential for clinical application if incorporated in conventional tooth paste that are readily available in the market