Topical anaesthesia for pain relief during high dose rate brachytherapy for carcinoma of the cervix

Abstract

"Purpose: To determine the clinical efficacy of a local anaesthetic spray of 10% xylocaine in reducing pain and discomfort in patients undergoing high dose rate (HDR) brachytherapy. Patients and Method: Ninety two consenting patients diagnosed with cervical cancer and planned for HDR as part of their treatment were enrolled for the study. Each patient had three sessions of brachytherapy following the standard procedures. In the first session all the patients had brachytherapy in the usual manner with conscious Sedation with parenteral diazepam and pentazocine. For the second and third sessions, they had treatment sessions using conscious sedation and 10% xylocaine spray and a control session using conscious sedation and a placebo spray with 0.9% normal saline (NS) respectively. Visual Analogue Scale (VAS) was used in assessing pain during each of the procedure. Results: Only 80 patients completed the study. Their age ranged from 2870 years with a median age of 54 years. The pretreatment VAS median scores in the treatment and the control sessions were similar at 0.275 and 0.200. However, the postprocedure median VAS scores were increased to 6.3 in the control group and 3.2 in the xylocainetreated group (P < 0.0001). The haemodynamic status including the blood pressure (BP) and pulse rates (PR) were similar pre and post procedure in both groups. Conclusion: Topical xylocaine spray is efficacious in reducing pain and discomfort in HDR Brachytherapy without any appreciable adverse effect."