The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies

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dc.contributor.authorNwuba, R. I.
dc.contributor.authorSodeinde, O.
dc.contributor.authorAnumudu, C. I.
dc.contributor.authorOmosun, Y. O.
dc.contributor.authorOdaibo, A. B.
dc.contributor.authorHolder, A. A.
dc.contributor.authorNwagwu, M.
dc.date.accessioned2018-10-08T10:18:25Z
dc.date.available2018-10-08T10:18:25Z
dc.date.issued2002-09
dc.description.abstractMalaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.en_US
dc.identifier.issn1098-5522
dc.identifier.otherInfection and Immunity 70(9), pp. 5328-5331
dc.identifier.otherui_art_nwuba_human_2002
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/916
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.titleThe human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodiesen_US
dc.typeArticleen_US

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