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A comparative review of the efficacy of 24-hour versus 48-hour dose regimen of amoxicillin/ clavulanic acid prophylaxis for postoperative infections following elective caesarean section at the University College Hospital, Ibadan, Nigeria.
(Zambia Medical Association, 2022) Oloko, O.O.; Ogunbode, O.O.; Obajimi, G.O.; Arowojolu, A.O
Objectives: To compare the efficacy of 24 hour versus 48 hour prophylaxis of amoxicillin/clavulanic acid in the prevention of postoperative infections. Study Design: This study was a randomized controlled clinical trial conducted in a tertiary hospital in Ibadan, Nigeria. Two hundred and fifty - two pregnant women scheduled for elective caesarean section were randomly assigned into two groups. After the initial pre-incision antibiotic a dmi n i s t r a t i o n , g r o u p A r e c e i v e d t h e Amoxicillin/Clavulanic Acid for 24 hours while group B received the same drug for 48hours. Main Outcomes: Participants were examined on the3rd, 10th and 17th post-operative days for evidence of infections. All entry and analysis of data was by computer using the Statistical Package for Social Sciences version 22 (IBM, New York).Statistically significant differences were determined at p value of< 0.05. Results: The incidence of postoperative wound infection, postoperative fever and endometritis in this study was 5.2%, 9.1% and 5.6% respectively. There were no significant differences in the incidence of postoperative wound infection, postoperative fever and endometritis between the two regimens of antibiotics.
Abortion: manual vacuum aspiration
(World Health Organization, 2017) Ogunbode, O. O.
Acceptability of artificial insemination by donor among infertile women attending the Gynaecological Clinic of the University College Hospital, Ibadan
(Wolters Kluwer - Medknow, 2017) Obajimi, G. O.; Ogunbode, O. O.; Adetayo, C. O.; Ilesanmi, A. O.
Background: Artificial insemination by donor (AID) is specifically indicated in cases of incurable male infertility. Acceptability depends on perceptions largely influenced by religious and sociocultural perspectives. Male factor accounts for 20-50% of the causes of infertility and shows geographic variation in Nigeria. Method: A descriptive cross-sectional survey of all infertile women attending the gynecology clinic of the University College Hospital, Ibadan, between January and June 2014. 181 self-administered questionnaires were distributed to all consenting infertile women, however only 163 were suitable for analysis. Data analysis was descriptive and inferential at 95% confidence interval and a P value of less than 0.05 was considered statistically significant. Result: The mean duration of infertility was 5.7 ± 4.33 years. Fifty seven (35.0%) respondents were willing to accept artificial insemination by donor, while ninety three (57.1%) were unwilling to accept artificial insemination. Socio-cultural factor (48.1%) was the major reason for non-acceptability of artificial insemination by donor. Acceptability of AID was influenced by adequate knowledge about the procedure (P < 0.01). Sixty percent of the respondents had good knowledge and over half of them obtained the information from the news/print media. In this Study, acceptability of AID was not influenced by the age of the respondents, family structure, duration or type of infertility or educational status. (P > 0.05). Conclusion: This study revealed a low acceptance rate for Artificial insemination by donor. Providing information on AID as a treatment option during counseling and routine infertility management may be the needed drive to improve awareness and promote uptake when necessary.
Acceptability of counseling and testing for HIV infection in women in labour at the University College Hospital, Ibadan, Nigeria
(Makerere University, 2011-03) Bello, F.; Ogunbode, O. O.; Adesina, O. A.; Olayemi, O.; Awonuga, O. M.; Adewole, I. F.
Background: Many patients are referred to labour ward as emergencies, and therefore do not benefit from the antenatal HIV counselling and testing and treatment offered to registered patients. Objective: To assess the acceptability and suitability of offering HIV counselling and testing to women of unknown HIV status presenting in labour. Methods: A cross-sectional study comprising counselling and obtaining consent for HIV testing among 104 unregistered patients who presented in labour over a 3-month period. Rapid and enzyme-linked immunosorbent assay screening was performed for 90 consenting respondents. Reactive results were confirmed by Western blot. Appropriate therapy was instituted. Results: Acceptance rate for HIV testing was 86.5%, prevalence of HIV was 6.7%. Women of lower educational status were more likely to accept testing in labour (OR: 0.3; 95% CI: 0.1-0.7; p=0.01); age, parity, occupation and knowledge of HIV had no influence. Most women (66.3%) had satisfactory knowledge of HIV. No one admitted to feeling coerced to test in fear of being denied care. Most refusals for screening were to avoid needle pricks (28.6%). Compared to ELISA screening test, specificity of the rapid test was 100%, sensitivity 85.7%, positive predictive value 100% and negative predictive value 98.8%. Attitude to testing was maintained on post-partum re-evaluation. Conclusion: The prevalence of HIV amongst unregistered parturients showed the importance of offering point-of-care HIV testing and intervention, especially in an environment where antenatal clinic attendance is poor. Rapid testing appeared to be acceptable and feasible in labour to prevent the mother-to-child transmission of HIV.
Acceptability of counselling and testing for HIV infection in women in labour at the University College Hospital, Ibadan, Nigeria
(The Faculty of Medicine, Makerere University, 2011-03) Bello, F. A.; Ogunbode. O. O.; Adesinsa, O. A.; Olayemi, O.; Awonuga, O. M.; Adewole, I. F.
Background: Many patients are referred to labour ward as emergencies, and therefore do not benefit from the antenatal HIV counselling and testing and treatment offered to registered patients. Objective: To assess the acceptability and suitability of offering HIV counselling and testing to women of unknown HIV status presenting in labour. Methods: A cross-sectional study comprising counselling and obtaining consent for HIV testing among 104 unregistered patients who presented in labour over a 3-month period. Rapid and enzyme-linked immunosorbent assay screening was performed for 90 consenting respondents. Reactive results were confirmed by Western blot. Appropriate therapy was instituted. Results: Acceptance rate for HIV testing was 86.5%, prevalence of HIV was 6.7%. Women of lower educational status were more likely to accept testing in labour (OR: 0.3; 95% CI: 0.1-0.7; p=0.01); age, parity, occupation and knowledge of HIV had no influence. Most women (66.3%) had satisfactory knowledge of HIV. No one admitted to feeling coerced to test in fear of being denied care. Most refusals for screening were to avoid needle pricks (28.6%). Compared to ELISA screening test, specificity of the rapid test was 100%, sensitivity 85.7%, positive predictive value 100% and negative predictive value 98.8%. Attitude to testing was maintained on post-partum re-evaluation. Conclusion: The prevalence of HIV amongst unregistered parturients showed the importance of offering point-of-care HIV testing and intervention, especially in an environment where antenatal clinic attendance is poor. Rapid testing appeared to be acceptable and feasible in labour to prevent the mother-to-child transmission of HIV.
Adverse childhood experiences and risky sexual behaviour among undergraduates in Ibadan
(Society of Gynaecology and Obstetrics of Nigeria (SOGON), 2015) Ogunbode, O. O.; Bello, F. A.; Sekoni, O.O; Ogunbode, A. M.; Akinola, I. T.; Adeniyi, A. A.
An assessment of ovarian cancer histologic types across the African Diaspora
(2021) George, S. H. L.; Omotoso, A.; Pinto, A.; Mustapha, A.; Sanchez-Covarrubias, A. P.; Umar, U. A.; Umar, A. B.; Oluwasola, T. A. O.; Okolo, C. A.; Anthony, U. U.; Ukekw, F. I.; Bakari, M. A.; Dahiru, A. M. C.; Abdullahi, H. I.; Abimiku, B. A.; Abdurrahman, A.; Usman, A.; Ahmed, S. A.; Usman, H. A.; Kabir, A.; Eleje, G. U.; Chiemeka, M. E.; Nzeribe, E.; Nweke, I.; Kadas, S. A.; Suleiman, D. E.; Ekanem, E.; Uche, U. M.; Paul, J.; Agwu, U. M.; Edegbe, F. O.; Anorlu, R. I.; Banjo, A.; Ajenifuja, K. O.; Fawole, A. A.; Kazeem, I. O. O.; Magaji, F.; Silas, O.; Athanasius, B. P.; Tamunomie, N. K.; Abudu, E. B. K.; Ango, I. G.; Abdullahi K.; Lawal, I.; Kabir, S. A.; Ekanem, V.; Ezeanochie, M.; Yahaya, U. R.; Castillo, M. N.; Bahall, V.; Chatrani, V.; Brambury, I.; Bowe, S.; Halliday, D.; Bruney, G.; Butler, R.; Ragin, C.; Odedina, F.; Chamala, S.; Schlumbrecht, M.; Audu, B.
Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016- December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sexcord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
An overview of the genetics of cervical cancer.
(2018) Gbadegesin, M. A.; Soremekun, O.; Oluwasola, T. A. O.; Okolo, C. A.; Oluwasola, A. O.
Cervical cancer is the fourth most common cancer in women, and the seventh of all human cancers. It is the most rampant cancer of the female genital tract in the developing world and manifests in two common histological subtypes: squamous cell carcinoma which is derived from squamous cells of the cervix and cervical adenocarcinoma which arose from the glandular cells. Most cases of deaths from cervical cancer occur in the less developed countries of the world where there are ineffective screening systems. Factors that increase the risk for developing cervical cancer include infection by Human Papilloma Virus (HPV) as the main direct factor and other indirect factors such as smoking, dietary habits, age, race, socioeconomic status, sexual history, use of oral contraceptives, high parity and the human immunodeficiency virus infection. Identifying the genetic alterations that predispose to or associate with cervical cancer will help in the screening of patients at risk of the cancer thereby allowing early diagnosis and prompt management with better outcomes. In this review we describe the role of HPV DNA integration into the host cellular genome, the effects of viral E6 and E7 proteins, and the loss of heterozygosity as genetic factors in cervical cancer.
Anaemia and its associated risk factors among pregnant women in the Gambia.
(2024) Oluwasola, T. A. O.; Amadi, A. O
Background: Anaemia is a global health problem affecting about a third of the world’s population. In pregnancy, it is a public health concern with consequences for mothers and infants, including maternal death and infant mortality. In low-income countries, 25% indirect maternal mortality and 30% neonatal deaths are due to anaemia in pregnancy. This study aimed to determine the prevalence of anaemia among pregnant women in The Gambia and identify common risk or predisposing factors associated with anaemia in pregnancy among them. Methods: This was a cross-sectional study of 180 consenting pregnant women, who attended two secondary-care level hospital for antenatal care between March and May 2023. They were selected by using a simple random sampling technique. Data were collected using a validated structured questionnaire and participants’ current antenatal cards while SPSS software version 26.0 was used for analyzing data. Results: The findings of this study shows that 21.7% and 8.3% of the pregnant women were anaemic at booking using 11.0g/dl and 10.0g/dl as cut off respectively with the mean haemoglobin concentration of 11.76+-1.36g/dl. The study revealed that anaemia during pregnancy is associated with factors such as educational level (p=0.048) and the average income per month (p=0.039). Majority of the women, (166, 92.2%), have taken malaria prophylaxis but only 95 (52.8%) admitted to sleeping under insecticide-treated mosquito nets which shows the low prevalence of Malaria among the participants (5.6%) Conclusion: The prevalence of anaemia among pregnant women in the Gambia is 21.7% which implies that anaemia is still a public health problem. Therefore, it is important for actions like early booking and improvement on health and nutritional education to be taken in order to reduce anaemia among pregnant women.
Anaemia in pregnancy
(Springer International, 2021) Ogunbode, O.; Ogunbode, O.
Anaesthesia considerations for the HIV positive parturient
(Association of Resident Doctors, University College Hospital, Ibadan, Nigeria, 2009-06) Adesina, O.; Oladokun, A.
The HIV epidemic in children parallels that among women on account of perinatal transmission. A combination of antiretroviral therapy and elective caesarean section reduces the rate of vertical transmission to <2%. Elective caesarean section independent of antiretroviral therapy decreases the risk of HIV vertical transmission from mother to baby. However, a caesarean section is a major surgical intervention that has well-reported complications. Women infected with HIV have been reported to be more susceptible to such complications. The multi-organ nature of HIV poses challenges at the time of surgery and anesthesia. Preoperative evaluation will allow a good prediction for the perioperative risk of the HIV-patient. The anesthesiologist should be aware of the possible toxic side effects or the possible interaction of antiretroviral drugs with the anesthetics. Some of these adverse effects may mimic signs and symptoms of the HIV disease itself. Regional anesthesia has been shown to be associated with reduced morbidity and mortality in a wide range of patients, including HIV positive parturients. Finally, the possibility of transmission in the health care setting highlights the need for anesthetists to enforce rigorous infection control policies to protect themselves, other health workers and their patients.
Anemia in pregnancy at two levels of health care in Ibadan, south west Nigeria
(Annals of African Medicine Society, 2011-12) Adesina, O.; Akinyemi, O.; Oladokun, A.
Background: In Africa, anemia in pregnancy contributes to non-attainment of the MDG goals 4 and 5. This study examined the prevalence and some risk factors for anemia at two levels of health care in the Ibadan metropolis. Methods: This was a retrospective study of the booking records of pregnant women at the University College Hospital (UCH, a profit-making tertiary institution) and Adeoyo Maternity Hospital (AMH, a secondary level institution offering free services) in Ibadan, September 1, 2008 to December 31, 2008. Eligible women had singleton pregnancies and no known chronic illnesses. Anemia was defined as packed cell volume (PCV) <30%, and degrees of anemia as mild (PCV 27–29%), moderate (PCV 19–26%), and severe (PCV below 19%). Statistical analysis was done by the Chi-square test, Fisher exact test, and t-test. A P value of <0.05 was considered significant. Results: Data from 2702 women (384 and 2318 from UCH and AMH, respectively) were available for analysis. About 30% of the women were anemic. The patients in UCH had higher mean PCV (33.03± 4.32 vs. 31. 04 ± 4.09, P = 0.00). A higher proportion of anemia was seen in patients presenting in Adeoyo (32.4% vs. 16.7%, P = 0.00). Factors associated with anemia included young age (P = 0.00), low parity (P = 0.00), and hospital type (P = 0.00). Parity and hospital type remained significant on logistic regression. Conclusion: Lower prevalence of anemia at the tertiary hospital maybe attributed to the higher socioeconomic status of the clientele. Short-term early antenatal management of anemia and long-term economic/educational empowerment is advocated.
Antenatal care utilisation among adolescent mothers in Ngozi Province, Burundi
(Wolters Kluwer ‑ Medknow, 2024) Iradukunda, L. I.; Ogunbode, O. O.; Arulogun, O. S.
Background: Globally pregnancy and childbirth complications are the leading cause of death among adolescents, with evidence showing that antenatal care (ANC) is a very effective preventive intervention. In Burundi, there is limited information on the extent to which pregnant adolescents utilise such services. Objective: To assess the ANC utilisation and factors associated with its use among adolescent mothers in Ngozi Province, Burundi. Materials and Methods: A cross-sectional, health facility-based study among 216 adolescent mothers who had given birth within two years preceding this study, using structured questionnaires and records from previous ANC booklets. A multistage random sampling technique was used to select respondents while the utilisation of ANC was determined by the frequency of ANC visits and the time when the women enrolled for the first ANC visit. Results: The majority (98.1%) of adolescent mothers in Ngozi Province used ANC services. Most respondents (64.8%) initiated ANC services within the first trimester while 57.8% attained the minimum of four recommended ANC visits. Marital status (P = 0.001), geographical location (P = 0.009), occupation of the partner (P = 0.002) and type of the last pregnancy (P = 0.012) were associated with ANC initiation within the first trimester while marital status (P < 0.001), respondent’s employment (P = 0.003) and type of last pregnancy (P < 0.001) were associated with appropriate ANC frequency. Conclusion: This study revealed a high use of ANC services among adolescent mothers, although more than one-third attended ANC late. There is therefore the need to put more effort into improving early booking for ANC.
Antenatal care visits’ absenteeism at a secondary care medical facility in Southwest Nigeria.
(Taylor & Francis, 2016) Oloko, O. O.; Ogunbode, O. O.; Roberts, O.; Arowolo, A. O.
Antenatal care (ANC) is a specialised pattern of care organized for pregnant women with the goal of maintaining good health and promoting safe delivery of healthy infants. It is an indispensable part of effective maternity care services. This study identified the factors responsible for absenteeism from ANC follow-up visits. It was a hospital-based prospective cross-sectional descriptive study conducted at a faith based secondary healthcare facility in Ibadan, Nigeria. Relevant data were retrieved using interviewer administered structured questionnaires and antenatal health record cards. The major reasons identified for absenteeism were delay in receiving hospital services due to long queues at service points and understaffing. The pregnant women aged 35 years and above were the most likely to miss the visits. Therefore, there is the need for hospital administrators and health care givers to make the services patient-friendly
Application of bayesian non parametric estimation on cervical cancer: A case study of University College Hospital, Nigeria.
(2021) Onatunji, A. P.; Folorunso, S. A.; Oluwasola, T. A. O.; Adesina, O. A.; Uthman, K. T.
Cervical cancer is the third most common malignancy in women worldwide, and in developing countries, it remains a leading cause of cancer-related death for women. The disease is a significant illness in women in Sub Sahara Africa Countries like Nigeria. Cervical cancer ranks as the 2nd most prevalent cancer among women in Nigeria and the most prevalent cancer among ages 15 – 44 years. Some of the identified risk factors of this disease have been wrongly captured in some statistical models. This consequentially makes the result of the analysis wrongly interpreted and concluded when the risk factors are continuous. This study is aimed at examining the Bayesian estimation of cervical cancer on a woman's age and survival period of the disease using the application of non-parametric techniques. The study is a means to apply Bayesian Nonparametric estimation on cervical cancer. The study findings reveal that women between ages 40 - 60 years have a significant increase in the probability of mortality from cervical cancer when the survival period is between stage I-IV. Also, there is an increase in woman's age and survival period of living with the disease which is significantly likely to decrease the mortality from cervical cancer in the study area.
Assessment of antenatal care satisfaction amongst postpartum women at the University College Hospital, Ibadan, Nigeria.
(2023) Adedeji, O. A.; Oluwasola, T. A. O.; Adedeji, F. M.
Background: Maternal mortality is unacceptably high especially in developing countries. About 287,000 women died during and following pregnancy and childbirth in 2020. The vast majority of these deaths (95 %) occurred in low and lower middle countries in 2020 and most could have been prevented. Every day in 2020, approxi-mately 800 women died from preventable causes related to pregnancy and childbirth. Utilization of antenatal visit has been shown to improve birth outcome as well as the maternal outcome during pregnancy-related events, giving a positive impact when the visit frequency and care are adequate while satisfaction has equally been an important outcome measures of quality of care. In order to improve feto-maternal outcome and turn the tide against maternal deaths, it is expedient to assess the satisfaction of women who had experienced antenatal care with the aim of identifying areas requiring additional attention. Objective: This study aimed to assess the level of antenatal care satisfaction of postpartum women and factors associated with satisfaction at the University College Hospital (UCH), Ibadan and their future intention for subsequent utilization of antenatal care. Methods: A descriptive cross-sectional study of 261 women in the postnatal ward using simple random sampling technique was conducted with an interviewer-administered structured questionnaire. Items in the questionnaire included sociodemographic and obstetric variables, assessment of quality of amenities, waiting time and level of satisfaction. Data was entered, cleaned and analyzed by computer using the Statistical Package for Social Sci-ences Version 23.0 (SPSS, IBM). The variables were summarized using frequencies, proportions, means and standard deviation. Chi Square was used for test of significance with the p-value set at P <0.05. Results: Of the 261 participants 176 (67.5 % percent) were aged 25–34 years; majority (244,93.5 %) had tertiary education while (189, 72.4 %) were skilled workers or professionals. Most of the women (243, 93.2 %) were Para 1–3 and the pregnancy was planned (80.8 %) while financing was mostly out of pocket (60.9 %). Only one-third of the participants has at least eight (8) antenatal contacts. In overall rating, most women (90.0 %) were satisfied with the antenatal care services received. The highest rating of satisfaction was with the competence of the service providers (90.4 %) especially with the care given to them and their unborn babies (90.4 %). The parity, distance of their home from antenatal clinic, number of antenatal contacts, number of health education sessions attended, total time spent, attitude of health workers, cost of services and desire to register again at the facility were statistically associated with patient’s satisfaction. Also, the number of antenatal visits was statistically associated with the fetal outcome. Conclusion: There is a high overall level of satisfaction with antenatal services among postpartum women in UCH. It is important to encourage women to register early to ensure they have adequate number of antenatal contacts and also participate in the health education sessions.
Assessment of serological markers of genital chlamydia trachomatis infection among the gynaecology patients attending Babcock University teaching hospital, Ilishan-Remo, Ogun state, Nigeria.
(2019) Ajani, T. A.; Elikwu, C. J.; Nwadike, V.; Babatunde, T.; Anaedobe, C. G.; Opeoluwa S.; Okangba, C.; Oluwasola, T. A. O.; Omeonu, A.; Faluyi, B.; Thompson, T. E.; Ebeigbe, E.; Ajani, M. A.; Joshua, A. K.; Kolawole, T.; Kristilere, H.; Meremikwu, C. M.; Mgbemena, L.; Nwaejike, C. S.; Salami, A.; Tantua, A.; Timothy, M.; Akagbusum, T.; Coker, A. O.
Genital Chlamydia trachomatis infection causes significant morbidity and mortality in women. A number of epidemiologic studies have suggested that Polymerase Chain Reaction (PCR) is more accurate as a diagnostic tool for Chlamydia trachomatis.However, the use of serological markers may be cost effective and practical in diagnosing and estimating the burden of the disease in resource limited countries.This study was aimed at determining the serological markers (IgG, IgM and IgA) of Chlamydia trachomatis, evaluate the association between Chlamydia trachomatis infection and the sociodemographic characteristics and clinical diagnosis of the participants. This was a cross sectional hospital-based study in which blood samples from 145 consenting participants were tested for IgG, IgM and IgA antibodies against Chlamydia trachomatis using enzyme linked immunosorbent assay and their clinical diagnosis, retrieved from their case notes. The cumulative prevalence of seropositivity for Chlamydia trachomatis (IgG, IgM, IgA) was 112 (77.2%) while 33 (22.8%) were seronegative. The overall predominant seromarker was IgG 91(62.8%) while IgM and IgA accounted for 85(58.6%) and 54(37.2%) respectively. A statistically significant association was found between Chlamydia trachomatis infection and PID (p value = 0.031), primary infertility (p value 0.011) and level of income (p value= (0,045).
Assessment of tubal factor contribution to female infertility in a low resource setting (southwest Nigeria): hysterosalpingography vs laparoscopy
(2005) Okunlola, M. A.; Adebayo, O. J.; Odukogbe, A. A.; Morhason-Bello, I. O.; Owonikoko, K. M.
Assisted reproductive techniques and gamete donation; knowledge, attitude and willingness to participate among students in a Nigerian tertiary institution
(Zambia Medical Association, 2020) Ogunbode, O. O.; Obajimi, G. O.
Background: Infertility is a worldwide problem affecting about 10-15% of married couples and has social, economic and psychological implications1. A significant number of couples will require assisted reproduction following failure of common treatment options. Undergraduates form a rich source of potential gamete donors and it is imperative to assess their knowledge, attitude and willingness to participate in the expanding gamete donor programs in a developing country like Nigeria. Objectives: This study aimed to assess the knowledge and attitude of participants about assisted reproduction and to further evaluate their willingness to donate gametes for assisted conception or act as surrogates. Methodology: This was a cross-sectional descriptive study of 1150 participants consisting of 511 male students and 639 female students of the University of Ibadan. Participants were selected by simple random sampling technique. A semistructured, self-administered questionnaire was used to obtain information on sociodemographic characteristics, knowledge, attitude and willingness to participate in gamete donor programs. Participation was voluntary and data obtained was treated with utmost confidentiality. Data was analyzed using the Statistical Package for Social Sciences (IBM SPSS, New York) version 22. Descriptive statistics were generated, and the results summarized with the aid of a bar chart and frequency tables. Results: Eight seven percent of the respondents had good knowledge of Assisted Reproductive Techniques (ART) and the most common source of awareness was the media (63.3%). More respondents were aware of sperm donation (75.5%) compared to egg donation (61.9%). Ninety percent of the participants were correctly able to identify the places where ART could be practiced in Nigeria. Most of the respondents (81.5%) supported ART services and the most common reason for not supporting was due to ethical considerations (45.1%). Only about 54.9% were willing to participate in gamete donor programs. Nine (0.8%) female respondents had previously participated in egg (oocyte) donation while none of the male respondents had ever donated sperm. About threequarters of the respondents demonstrated good knowledge about the practice of surrogacy. Conclusion: Despite good knowledge about ART, only about half of the respondents were willing to participate in gamete donor programs. Religious and health concerns were primarily responsible for their reluctance. Providing Information, Education and Communication (IEC) materials about the safety of ART will increase the level of awareness and confidence in ART thereby increasing participation by potential donors particularly undergraduates in a developing country like Nigeria.
Asymptomatic bacteriuria among HIV positive pregnant women
(Taylor and Francis, 2010-06) Awolude, O. A.; Adesina, O. A.; Oladokun, A.; Mutiu, W. B.; Adewole, I. F.
The prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. This prevalence might, even, be higher in patients with human immunodeficiency virus infection. Hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled HIV infected pregnant women attending PMTCT unit of Antiretroviral Clinic of University College Hospital, Ibadan, Nigeria between 1st May and 30th September 2007. Information was obtained on the socio-demographic characteristics of the subjects, CD4 count and viral load. Microbial culture was carried out on aseptically collected urines from the patients. Statistical analysis was done with SPSS 12 package. There were 161 analyzable samples from the participants. The mean age and gestational age at presentation of participants was 30.49 ± 4.3 years and 27.3 ± 3.2 weeks, respectively with modal parity of 2. Twenty-five (15.5%) of the urine samples significantly grew bacteria. The CD4 cells were significantly lower and the viral loads significantly higher (250.52 vs. 355.57 cells/mm3; 88,731 vs. 55,384 copies/ml; p = <0.0000) for the urine culture positive patients. Eshcherichia coli were isolated in 48%, Proteus in 16.0%, Klebsiella in 8.0% and Staphylococcus aureus in 28.0% of the urine positive cultures. The study showed that the prevalence of asymptomatic bacteriuria among PLWHAs is high. The microbial isolate from the urine samples were not different from those of HIV-negative patients.