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Item Guinea worm disease and its persistence in some rural communities in Nigeria(2007) Morenikeji, O. A.; Alade, A. O.; Odaibo, A. B.Studies were carried out in six villages of Ogun State, Nigeria from January to December 2004 to identify the reasons for the persistence of guinea worm disease in spite of eradication measures. Pre-tested structured questionnaires were administered to 250 head of households in the endemic villages to assess their knowledge attitude and practice (KAP) in the management of guinea worm disease. The overall prevalence of infection for the study-period was 1.0%. 96.0% of the respondents depended solely on ponds for drinking water during the dry season. 80.0% of the respondents had been infected before 68.0% think that the disease is caused by spiritual attack, while 4.0% associated the disease to drinking bad water. 77.5% did not know if it is possible to prevent the disease. It was observed that immigrant farm labourers and apathy on the part of eradication officials may play vital roles in the transmission of the disease in the area. This study shows that there is need to ascertain and specifically address reasons for the persistence of the disease in areas still endemic.Item Spatial variation in physical and chemical parameters and benthic macro-invertebrate fauna of River Ogunpa, Ibadan(2005) Atobatele, O. E.; Morenikeji, O. A.; Ugwumba, O. A.A fluviatile ecosystem, River Ogunpa, was studied between the months of May and July 2000, to assess spatial variations in physical and chemical parameters and benthic macro-invertebrate faunal composition. Water and qualitative benthic samples were collected four times from five stations located along the river for laboratory analysis. High mean value of biochemical oxygen demand (BOD) of 20.15 ± 4.18 mgO2/l, chemical oxygen demand (COD) of 121.95 ± 19.04 mg02/l ammonia of 1.53 ± 0.44mg/l, total suspended solids (TSS) of 152.2+12.85mg/l, lead of 0.126 ± 0.06mg/l, copper of 0.3+0.07mg/l and zinc of 0.49 ± 0.07mg/l were recorded. Analysis of variance (ANOVA) showed significant differences (P<0.05) in mean values of pH, dissolved oxygen (DO), COD, turbidity, iron and copper from the five stations. Six benthic macroinvertebrate fauna; Melanoides tuberculata, Physa waterloti, Bulinus globosus, Tubifex spp; Chironomus spp and Brachydeutera spp. were recorded. The result showed that the river is under pollutional stress from oxygen demanding organic wastes. Heavy metals analyzed show that lead, copper and zinc levels may be increasing to dangerous levels in the river. Spatial variations along the river showed some stations to be more polluted than others. All the benthic macro-invertebrate fauna recorded were pollution tolerant species.Item Evaluation of the effectiveness of abate™ used for the treatment of community drinking ponds in the Nigeria guineaworm eradication program(Tapas Institute of Scientific Research and Development, 2005) Morenikeji, O. A.; Ajulo, B. O.; Odaibo, A. B.A study was carried out to ascertain the effectiveness of the Abate™ (0-0-0(1)-0(1)-tetramethyl - 0-0(1)-thiodi-P-phenylene phosphorothiote) an organophosphorous compound used for the treatment of community drinking ponds in the Nigeria Guinea Worm Eradication Programme in South-West Zone of Nigeria. The Abate™ was used in treating 3 large rectangular concrete tanks lined with pond mud, and filled with pond water harbouring cyclops, the crustacean vector of guinea worm disease. A fourth tank containing untreated water served as control. The initial and final cyclops populations of each tank was determined daily for seven days and then weekly up to the 28th day after Abate™ treatment. The standard concentration used in guinea worm eradication program (0.1ml of Abate™ to 50 litres of water) was added. At this concentration, cyclops is known to become paralysed within 72 hours. It was deduced that the population of cyclops, Thermocydops decipiens, was not effectively controlled since it took more than 5, 6 and 14 days to eliminate them from tanks A, B and C respectively. The population of cyclops however, increased in the control tank over the study period. In the control of guinea worm disease vectors, it is necessary to take into cognisance the potency of the chemical used in order to achieve the desired result.Item Cyclopoid copepods in domestic water sources in three villages in Akinyele local government area of Oyo State, Nigeria(2002) Falode, O. A.; Odaibo, A. B.The distribution and infective rates of cyclopoid copepods ( the vectors of guineaworm, Dracunculus medinensis ) in ponds was studied in 3 infected villages in Akinyele Local Government Area of Oyo state, Nigeria during the period of September 1994 to January 1996 (the peak period of guineaworm eradication activities in the country). The density of cyclopoid copepods was highest in the dry season, reaching 149.8 copepods/litre in February 1995. The abate (Temephos) application and amount of rainfall affected the cyclops in ponds. Thermocyclops, Mesocyclops and Halicyclops species of cyclops were recovered from the ponds while none was found to be infected with D.medinensis larvae.Item Management and attitudes of villagers towards boreholes in guineawarm eradication in Akinyele local government Area of Oyo State, Nigeria(2002) Falode, O. A.; Odaibo, A. B.Studies on the management and attitudes of villagers to boreholes as a source of water in guineaworm eradication was carried out in 4 villages, Alagba, Deinlokun, Iware and Idi-omo in Akinyele Local Government Area of Oyo State, Nigeria.The findings showed that the borehole reduced or eradicated the guineawonn disease in villages studied but its reliability and efficiency was threatened by insufficient borehole water (especially in villages with a population exceeding 500) and lack of a maintenance schedule by the local government area. It was concluded that it is necessary to carefully consider the reliability of the borehole and the size and the distribution of the population they will serve before they are constructed, in order that the full benefit of water supply intervention can be achievedItem Attitudes and practices towards abate application in a village in Akinyele local government area of Oyo State, Nigeria(Klobex Academic Publishers, 2001-09) Falode, O. A.; Odaibo, A. B.A study was carried out in Oyeteju Village in Akinyele Local Government Area of Oyo State to determine attitudes of the villagers to treating their drinking pond with Abate (Temephos). The findings showed that all women respondents fetched all their drinking water from the village pond. They all claimed to filter the drinking water, 83.3% claimed to add alum while 25% claimed to boil water. Only 75% knew why Abate was applied to pond despite previous education on Abate. 41.7% support Abate application because it will kill the guineaworm 'germs’ in water while 25% Support it because it will bring about good health to villagers. All the respondents claimed not to be affected by the application of Abate to pond water despite the fact that 33.3% said the pond water turned black while 8.3% said it turned reddish. Their strong belief in their pond which is their god and the colour change did not make the villagers go against the application of Abate to their pond. This was so because health education on Abate preceded its application. It was unfortunate however that the Abate application was not sustained in the village. Abate application in this village was accepted as a temporary measure while villagers wait expectantly for their own safe source of water preferably a borehole. The study shows the need for health education to proceed the application of Abate and the need to train villagers on how to apply the Chemical in order to sustain the application for effective control.Item Occurrence and distribution of rhabditis axei (rhabditida; rhabditidae) in African giant snails in southwestern Nigeria(De Gruyter Open Ltd., 2000) Odaibo, A. B.; Dehinbo, A. J.; Olofintoye, L. K.; Falode, O. A.African giant snails (Archachatina marginata ovum Pfeffer, 1858; A. marginata saturalis Philippi, 1849 and Achatina achatina Linne, 1758) were examined for the occurrence of Rhabditis axei Cobbold. 1884.Differences in parasite intensity between size groups of snails were highly significant (P < 0.05) for die 3 species compared. The mean egg and larval output per gram of faeces was higher in larger snails. The mean intensity of the nematode eggs excreted was higher (P < 0.05 ) than the mean of larval output for the 3 species of snails. The distribution of R. axei within the snail hosts revealed site preferences. They are mostly (88 %) located in the rectum of the snails.Item In-vitro antimalarial activities of withania somnifera, gymnema sylvestre, ocimum gratisimum and cajanus cajan(Medimond, 2010-08) Morenikeji, O. A.; Pillai, C. R.; Vakcha, N.; Dash, A. P.A study was carried out to determine the efficacy of four plants, Withania somnifera (WS), Gymnema sylvestre (GS), Ocimum gratisimum (OG) and Cajanus cajan (CC) traditionally used in the treatment of malaria in Nigeria and India. Ethanolic extracts of these plants were tested in vitro on choloroquine sensitive (MRC-pf-2) and resistant (MRC-pf-303) strains of Plasmodium falciparum for their anti-malarial activity. The IC(50) values of these plants were calculated and found to be OG (IC(50) = 23.48 µg/ ml), WS (IC(50)= 45.24 µg/ ml), GS (IC(50) = 45.25 µg/ ml) for the pf sensitive strain and CC (IC(50) = 47.52 µg/ ml) in the pf resistant strain. Others, GS IC(50) = 69.70 µg/ ml (resistant strain), CC IC(50) = 72.3lµg/ ml (sensitive strain), WS IC(50)= 88.30 µg/ ml (resistant strain), OG IC(50)= 121.76µg/ ml (resistant strain). Higher concentrations caused total inhibition of the parasite at the ring stage. Ocimum gratisimum showed the most significant antimalarial effect on the parasites sensitive strain. Results lend some credence to the use of medicinal plants in the treatment of malaria and the need to study the active constituents of effective ones.Item In-vitro antimalarial activities of withania somnifera, gymnema sylvestre, ocimum gratisimum and cajanus cajan(Medimond, 2010-08) Morenikeji, O. A.; Pillai, C. R.; Vakcha, N.; Dash, A. P.A study was carried out to determine the efficacy of four plants, Withania somnifera (WS), Gymnema sylvestre (GS), Ocimum gratisimum (OG) and Cajanus cajan (CC) traditionally used in the treatment of malaria in Nigeria and India. Ethanolic extracts of these plants were tested in vitro on choloroquine sensitive (MRC-pf-2) and resistant (MRC-pf-303) strains of Plasmodium falciparum for their anti-malarial activity. The IC(50) values of these plants were calculated and found to be OG (IC(50) = 23.48 µg/ ml), WS (IC(50)= 45.24 µg/ ml), GS (IC(50) = 45.25 µg/ ml) for the pf sensitive strain and CC (IC(50) = 47.52 µg/ ml) in the pf resistant strain. Others, GS IC(50) = 69.70 µg/ ml (resistant strain), CC IC(50) = 72.3lµg/ ml (sensitive strain), WS IC(50)= 88.30 µg/ ml (resistant strain), OG IC(50)= 121.76µg/ ml (resistant strain). Higher concentrations caused total inhibition of the parasite at the ring stage. Ocimum gratisimum showed the most significant antimalarial effect on the parasites sensitive strain. Results lend some credence to the use of medicinal plants in the treatment of malaria and the need to study the active constituents of effective ones.Item The guinea worm disease(Textflow Limited, Ibadan, Nigeria, 2015-03) Morenikeji, O. A.