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Item Haematinic potencies of the aqueous crude extracts of ficus mucoso and senna occidentalis in rabbits(Ibadan Biomedical Communications Group, 2009) Adedapo, A. A.; Ayodele, A. E.; Ogunshe, A. A. O.; Oyeyemi, M. O.; Idowu, S. O.; Ola-Davies, O. E.; Ademola, I. O.A total of 20 domestic rabbits divided into 4 groups of 5 animals per group were used in this study to assess the haematinic potencies of the aqueous crude extracts of Ficus mucoso and Senna occidentalis and this was then compared with that of a proprietary haematinic, Haematopan B12®. Group A animals (control) were not bled but those in groups B, C and D were bled to induce anaemia. Group B animals were treated with Haematopan B12®, a commercially prepared haematinic, and groups C and D were treated with the aqueous crude extracts of Senna occidentalis (Linn) Link and Ficus mucoso Welw. ex Ficalho respectively. The post-haemorrhage treatment haematologic values were obtained at given intervals (7 days) and compared with the pre-haemorrhagic values earlier obtained. The study showed that all the experimental animals showed accelerated recovery since these animals had excellent response in terms of white blood cell (WBC) and its differentials, red blood cell (RBC) count, packed cell volume (PCV) and haemoglobin (Hb) concentration. Thus the extracts of Ficus mucoso and Senna occidentalis have comparative haematinic potencies as Haematopan B12®Item The reproductive implications of clomiphene citrate on sperm cells during the epididymal transit of spermatozoa in male wistar rats(2006) Oyeyemi, M. O.; Towobola, B. A.; Ola-Davies, O. E.The reproductive implications of Clomiphene citrate (CC) on male Wistar rats revealed the reactions of the rats to CC at different dosages (varied). Results revealed detrimental effects at a higher dosage. In the caput of the epididymidis, the mean percentage motility in group B Wistar rats (20.0 ±8.66) and group C Wistar rats (23.3 ±3.33) was significantly lower (P<0.05) than group A Wistar rats (42.0 ± 2.00). The drug did not influence the percentage livability of the spermatozoa in the caput epididymidis. In the corpus epididymis the mean percentage motility for groups A — C were 56.00 ±2.45, 25.56 ±7.50, 13.00 ±5.77, respectively. Group A value was significantly higher than those of groups B and C. The percentage livability was higher in-group A than B and C. The concentration of the spermatozoa was significantly higher in group A (78.25 ±6.97. 106) than groups B (53.75 ±1.89. 106), though this is not significantly different (P<0.05). These findings were discussed in relation to the significance of the drug as a fertility enhancer in infertile animals. The reproductive implications of the drug were studied in the epididymis of Wistar rats with no adverse effects when used at the recommended dose. The drug can therefore be used to boost the reproductive potential of infertile male animals.Item Prevalence of Eimeria oocysts in West African dwarf goat at the University of Ibadan farm(Nigerian Society for Animal Production, 2002) Ola-Davies, O. E.; Oyeyemi, M. O.; Saba, A. B.; Ajala, O. O.An outbreak of acute coccidiosis is reported in West African Dwarf (WAD) goats kept under semi- intensive management system at the University of Ibadan farm. During the period of the outbreak, clinical signs observed among the animal included anorexia, fever, coughing, ocular and nasal discharges and diarrhoea. Sixty nine out of eighty-five (85%) animals were scouring, 6 out of 20 (30%) pregnant does aborted, 8 out of 80 (10%) died through severe infection. Average oocyst counts was 2.73 x 10(5)/gram faeces in kids and 0.9 x 10(3)/gram faeces in adult goats. Eimeria species predominant in goats and percentage occurrence were E. arloingi (77.5%), E. ninakohlyakimovae (62.89%), E. hirci (58.6%). E. alijevi (39.5%). Areas of glandular degeneration and necrosis of epithelium of the small intenstine were seen. Also coccidia schizonts, immature oocysts, and neutrophilic infiltrations can be seen in the intestinal mucosa. The presence of pathogenic species of the Eimeria in WAD goats suggest that coccidiosis may be contributing to the enteric syndromes, poor feed conversion and low productivity.Item Effect of successive ejaculations on the spermiogram of West African dwarf goats (Capra hircus L.)(Faculty of Veterinary Medicine, University of Zagreb, 2000) Oyeyemi, M. O.; Akusu, M. O.; Ola-Davies, O. E.Twenty healthy adult male (bucks) West African dwarf goats (WADG) aged between 2 to 4 years and with a mass of from 16 to 20 kg were used in this study. They were randomly assigned into four groups of five bucks per group. In group A, semen was collected once a week for a period of eight weeks, while in group B semen was collected twice a week for a period of eight weeks, once a day for 21 days in group C, and twice daily at an interval of five hours for 21 days in group D. Live body masses, height at withers, scrotal length and scrotal circumference were not affected by successive ejaculations. The ejaculate volume decreased as the frequency of ejaculations increased, although the decrease was not significant (Group A 0.44±0.07, B 0.41±0.08, C 0.38±0.07 and D 0.36±0.08 ml) while the ejaculate colour was either milky or creamy. Mass sperm movement showed swirling waves and scored 4 in all groups, while the percentage progressive motility ranged between 88.7±3.10 and 94.54±3.00%. Percentage of live spermatozoa (Group A 96.57±2.40, B 96.24±2.53, C 96.10±2.28 and D 96.10±2.50%) was not affected by successive ejaculations although a decrease in sperm concentration was observed as the number of successive ejaculations increased. There was a significant increase (P<0.05) in abnormal spermatozoa as frequency of ejaculation increased.Item Morphological changes in sperm cells during epididymal transit in West African dwarf buck(2000) Oyeyemi, M. O.; Ola-Davies, O. E.; Oke, O. A.; Idehen, C. O.The spermatozoa characteristics during epididymal transit were studied .in healthy West African dwarf (WAD) goat bucks. The caput epididymis had a value of 27.0% of abnormal sperm cell, which is significantly different (P<0.05) from the 21.0% of corpus and 23.0% of the cauda epididymis. There was no significant difference (P>0.05) between the values of corpus and caudal epididymis. The caput epididymis also had 6.0% spermatozoa with proximal cytoplasmic droplets which differed significantly (P<0.05) from that of the corpus (1.20%) and the cauda (0.9%), The values for coiled tails and tire total abnormal sperm cells showed that caput epididymis had higher abnormal spermatozoa, which was closely followed by cauda while the corpus epididymis had the least. There were more spermatozoa with looped tails in the cauda epididymis (1.68%) than in other segment (corpus: 0.95% and caput: 0.80%). The testicular and epididymal parameters were positively correlated (weight of testis and epididymis; weight of testis, scrotal circumference, testicular circumference, weight of epididymis and weight of testis (r = >0.05) except the correlation values between length of epididymis and length of tests (r = 0.30).Item The toxic effects of the prolonged administration of chloramphenicol on the liver and kidney of rats(Biomedical Communications Group, Ibadan, Nigeria, 2000) Saba, A. B.; Ola-Davies, O.; Oyeyemi, M. O.; Ajala, O.The toxic effect of chloramphenicol on the liver and kidney was studied in laboratory Wistar rats. 16 adult rats of both sexes randomly divided into two groups were used. 10 animals in the test group were administered with chloramphenicol orally using rat cannula at human infant recommended dosage of 25mg/kg body weight given once daily for a period of 16 days. The 6 animals in the control group were only administered with 0.9% physiological saline orally over the same period of time. Serum enzymes and levels of serum bilirubin, urea, and creatinine were evaluated to establish any hepatic or renal dysfunction. There was statistically significant increase in aspartate aminotransferase (P<0.05) and alanine aminotransferase (P<0.001) serum levels in the test animals. The increase in serum alkaline phosphatase was not statistically significant (P>0.05). Hyperbilirubinaemia was observed in the rat administered with chloramphenicol, the difference in the mean value of the test and control animals were significant for total and conjugated bilirubin. (Total bilirubin P<0.01; Conjugated bilirubin P<0.05). The average time taken to establish anaesthesia was shorter in the test animals than in animals in the control group, the difference in the mean values was significant (P<0.05). Serum urea and creatinine levels were elevated in the test animals, the increase is only statistically significant for serum urea (P<0.05) but not significant for creatinine (P>0.05). Histopathology revealed vascular congestion and foamy cytoplasm of hepatocytes at the centrilobular region of the liver but did not reveal any damage done to the renal tissue. It was concluded that chloramphenicol may not be nephrotoxic but may have toxic effects on the liver.