FACULTY OF CLINICAL SCIENCES

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Author: search.filters.author.Adetayo, C. O.Has files: Yes

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    Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial
    (The Wellcome Trust, 2018) Shakur-Still, H.; Roberts, I.; Fawole, B.; Kuti, M.; Olayemi, O. O.; Bello, A.; Huque, S.; Ogunbode, O.; Kotila, T.|; Aimakhu, C.; Okunade, O. A.; Olutogun, T.; Adetayo, C. O.; Dallaku, K.; Mansmann, U.; Hunt, B. J.; Pepple, T.; Balogun, E.
    Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH. We evaluated the effect of TXA on fibrinolysis and coagulation in a sample of WOMAN trial participants. Methods: Adult women with a clinical diagnosis of PPH were randomised to receive 1 g TXA or matching placebo in the WOMAN trial. Participants in the WOMAN trial at University College Hospital (Ibadan, Nigeria) also had venous blood taken just before administration of the first dose of trial treatment and again 30 (±15) min after the first dose (the ETAC study). We aimed to determine the effects of TXA on fibrinolysis (D-dimer and rotational thromboelastometry maximum clot lysis (ML)) and coagulation (international normalized ratio and clot amplitude at 5 min). We compared outcomes in women receiving TXA and placebo using linear regression, adjusting for baseline measurements. Results: Women (n=167) were randomised to receive TXA (n=83) or matching placebo (n=84). Due to missing data, seven women were excluded from analysis. The mean (SD) D-dimer concentration was 7.1 (7.0) mg/l in TXA-treated women and 9.6 (8.6) mg/l in placebo-treated women (p=0.09). After adjusting for baseline, the D-dimer concentration was 2.16 mg/l lower in TXA-treated women (-2.16, 95% CI -4.31 to 0.00, p=0.05). There was no significant difference in ML between TXA- and placebo-treated women (12.3% (18.4) and 10.7% (12.6), respectively; p=0.52) and no significant difference after adjusting for baseline ML (1.02, 95% CI -3.72 to 5.77, p=0.67). There were no significant effects of TXA on any other parameters. Conclusion: TXA treatment was associated with reduced D-dimer levels but had no apparent effects on thromboelastometry parameters or coagulation tests.
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    Acceptability of artificial insemination by donor among infertile women attending the Gynaecological Clinic of the University College Hospital, Ibadan
    (Wolters Kluwer - Medknow, 2017) Obajimi, G. O.; Ogunbode, O. O.; Adetayo, C. O.; Ilesanmi, A. O.
    Background: Artificial insemination by donor (AID) is specifically indicated in cases of incurable male infertility. Acceptability depends on perceptions largely influenced by religious and sociocultural perspectives. Male factor accounts for 20-50% of the causes of infertility and shows geographic variation in Nigeria. Method: A descriptive cross-sectional survey of all infertile women attending the gynecology clinic of the University College Hospital, Ibadan, between January and June 2014. 181 self-administered questionnaires were distributed to all consenting infertile women, however only 163 were suitable for analysis. Data analysis was descriptive and inferential at 95% confidence interval and a P value of less than 0.05 was considered statistically significant. Result: The mean duration of infertility was 5.7 ± 4.33 years. Fifty seven (35.0%) respondents were willing to accept artificial insemination by donor, while ninety three (57.1%) were unwilling to accept artificial insemination. Socio-cultural factor (48.1%) was the major reason for non-acceptability of artificial insemination by donor. Acceptability of AID was influenced by adequate knowledge about the procedure (P < 0.01). Sixty percent of the respondents had good knowledge and over half of them obtained the information from the news/print media. In this Study, acceptability of AID was not influenced by the age of the respondents, family structure, duration or type of infertility or educational status. (P > 0.05). Conclusion: This study revealed a low acceptance rate for Artificial insemination by donor. Providing information on AID as a treatment option during counseling and routine infertility management may be the needed drive to improve awareness and promote uptake when necessary.
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    Serum adiponectin levels in normotensive and pre-eclamptic women at the University College Hospital, Ibadan, Nigeria
    (College of Medicine, University of Ibadan, Nigeria, 2018) Akinpelu, O. M.; Bello, F. A.; Awolude, O. A.; Adetayo, C. O.; Akinwunmi, B. O.; Odukogbe, A. A.
    Background: Adiponectin is a hormone produced mainly by adipocytes. The levels of adiponectin are inversely related to insulin resistance, hypertension and obesity. Physiological insulin resistance is exaggerated in pre-eclamptic women. The objective of the present study was therefore to compare serum adiponectin levels in pre-eclamptic patients and normotensive patients. Methods: This prospective study was conducted among one hundred and twenty women. Purposive sampling technique was used to select all consenting participants, consisting of sixty pre-eclamptic patients as cases and sixty normotensive pregnant women at comparable gestational age as control. Concentration of serum adiponectin was measured by using enzyme linked immunosorbent assay (ELISA) method. Results: Serum levels of adiponectin were significantly higher in the pre- eclamptic group(p<0.001). Body mass index was also significantly higher in women with pre eclampsia (p<0.01).In the pre-eclamptic patients, serum levels of adiponectin showed a weak negative correlation with BMI (r= -0.16, p= 0.22) and no correlation was found in normotensive patients. Conclusion: This study showed a clear distinction in the serum adiponectin concentration between preeclamptic and normotensive pregnant women. The impact of BMI on serum adiponectin in both groups also differs. Therefore, serum adiponectin may be useful in predicting pre-eclampsia.