FACULTY OF CLINICAL SCIENCES

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Author: search.filters.author.Akinwunmi, B. O.

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    Serum adiponectin levels in normotensive and pre-eclamptic women at the University College Hospital, Ibadan, Nigeria
    (College of Medicine, University of Ibadan, Nigeria, 2018) Akinpelu, O. M.; Bello, F. A.; Awolude, O. A.; Adetayo, C. O.; Akinwunmi, B. O.; Odukogbe, A. A.
    Background: Adiponectin is a hormone produced mainly by adipocytes. The levels of adiponectin are inversely related to insulin resistance, hypertension and obesity. Physiological insulin resistance is exaggerated in pre-eclamptic women. The objective of the present study was therefore to compare serum adiponectin levels in pre-eclamptic patients and normotensive patients. Methods: This prospective study was conducted among one hundred and twenty women. Purposive sampling technique was used to select all consenting participants, consisting of sixty pre-eclamptic patients as cases and sixty normotensive pregnant women at comparable gestational age as control. Concentration of serum adiponectin was measured by using enzyme linked immunosorbent assay (ELISA) method. Results: Serum levels of adiponectin were significantly higher in the pre- eclamptic group(p<0.001). Body mass index was also significantly higher in women with pre eclampsia (p<0.01).In the pre-eclamptic patients, serum levels of adiponectin showed a weak negative correlation with BMI (r= -0.16, p= 0.22) and no correlation was found in normotensive patients. Conclusion: This study showed a clear distinction in the serum adiponectin concentration between preeclamptic and normotensive pregnant women. The impact of BMI on serum adiponectin in both groups also differs. Therefore, serum adiponectin may be useful in predicting pre-eclampsia.
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    Multimoda hyperspectroscopy screening in women at risk of cervical cancer: results of a pilot study in a developing country
    (Wolters Kluwer - Medknow, 2017) Awolude, O. A.; Akinwunmi, B. O.; Adewole, I. F.
    Background: Screening and treatment of pre-cancerous lesions is important for prevention of cervical cancer. Currently, most available screening tests for cervical cancer are limited by low sensitivity, prohibitive costs, logistics and technical concerns. This study evaluates the role of multimodal hyperspectroscopy (MHS) as a cost-effective, sensitive and user-friendly point-of-care machine for early detection in women at risk of pre-cancer lesions. Materials and Methods: Multimodal hyperspectroscopy of the cervix using the LuViva® Advanced Cervical Scan was performed first in a 1-minute procedure among 100 previously screened for cervical cancer using either visual inspection after application of acetic acid (VIA) or cytology within the last 120 days. This was then followed by obtaining human papilloma virus (HPV) samples and biopsies from women for histology. Results: Of the 22 women with abnormal Pap tests of at least low‑grade squamous intraepithelial lesion, 3 had CIN2+, 6 had CIN1, 4 were free of dysplasia at histopathology while 9 had cervicitis. All 3 of the CIN2+ recorded high likelihood of CIN2+ by MHS. However, HPV was negative for all 3 women. The machine classified 1 of 1 CIN1s and 7 of the 13 women without dysplasia or cervicitis as low or moderate risk for CIN2+ (40% specificity); of the 37 women who were VIA+, 81% were classified as high risk, and 66% of 37 women with normal Pap tests and biopsy were either at moderate or low risk. Conclusions: The findings from this pilot study show that MHS reduced the percentage of unnecessary colposcopy and biopsy by 37.5%. It was also able to differentiate between VIA+ and Pap negative women suggesting its potential of being a point-of-care primary and objective screening test.
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    Knowledge of the human papilloma virus vaccines, and opinions of gynaecologists on its implementation in Nigeria
    (2013-06) Morhason-Bello, I. O.; Adesina, O. A.; Adedokun, B. O.; Awolude, O.; Okolo, C. A.; Aimakhu, C. O.; Akinwunmi, B. O.; Oladokun, A.; Adewole, I. F.
    The objective of this study was to determine the knowledge and perception of Nigerian Obstetricians and Gynaecologists towards human papilloma virus vaccine use in Nigeria. A cross sectional study was conducted amongst participants that attended the 42nd Society of Gynaecology and Obstetrics of Nigeria. The findings revealed that 44.5% knew the correct HPV vaccine schedule. Regarding implementation in Nigeria, 87.4% suggested its incorporation into the national immunization program and about a third agreed that it should be a precondition for school enrolment. Regression analysis showed that senior residents were more likely to have adequate knowledge of the vaccine compared to junior residents (AOR 7.181 95% CI OR=1.792 – 28.782). We conclude that the knowledge of eligibility and schedule is poor. It is recommended that adequate information should be provided to this group of health workers because of their strategic position in its implementation in Nigeria
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    Knowledge of the human papilloma virus vaccines, and opinions of gynaecologists on its implementation in Nigeria
    (Women’s Health and Action Research Centre, 2013) Morhason-Bello, I. O.; Adesina, O. A.; Adedokun, B. O.; Awolude, O.; Okolo, C. A.; Aimakhu, C. O.; Akinwunmi, B. O.; Oladokun, A.; Adewole, I. F.
    The objective of this study was to determine the knowledge and perception of Nigerian Obstetricians and Gynaecologists towards human papilloma virus vaccine use in Nigeria. A cross sectional study was conducted amongst participants that attended the 42nd Society of Gynaecology and Obstetrics of Nigeria. The findings revealed that 44.5% knew the correct HPV vaccine schedule. Regarding implementation in Nigeria, 87.4% suggested its incorporation into the national immunization program and about a third agreed that it should be a precondition for school enrollment. Regression analysis showed that senior residents were more likely to have adequate knowledge of the vaccine compared to junior residents (AOR 7.181 95% CI OR=1.792 – 28.782). We conclude that the knowledge of eligibility and schedule is poor. It is recommended that adequate information should be provided to this group of health workers because of their strategic position in its implementation in Nigeria.