Ophthalmology
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Item 5 Fluorouracil versus mitomycin-c as adjuncts to conjuctival autograft in preventing pterygium recurrence(Springer, 2012) Bekibele, C. O.; Ashaye, A.; Olusanya, B.; Baiyeroju, A.; Fasina, O.; Ibrahim, A. O.; Ogun, O.To compare the efficacy of 5-fluorouracil (5-FU) with mitomycin C (MMC) in preventing pterygium recurrence when used as an adjuvant following pterygium excision with conjunctival autograft. Low-dose MMC combined with conjunctival autograft is an effective treatment for preventing recurrence following pterygium excision, but safety, cost, and availability limit its use in developing countries. There is a paucity of data on the efficacy of 5-FU when used in Africa as an adjuvant to conjunctival autograft following pterygium excision. This is a randomized controlled prospective trial using either 50 mg/ml 5-FU or 0.01% MMC. Eighty eyes of 80 subjects were studied. Forty-six subjects with a mean age 49.8 ± 13.8 years were treated with 5-FU (USD 13.0 per unit), while 34 patients with a mean age 51.9 ± 12.1 years were treated with MMC (USD 20.0 per unit). There was no significant difference in mean age between the two groups (p = 0.48). The ratio of male to female patients in both groups was similar at 0.92:1 for the 5-FU group and 1:1 for the MMC group (p = 0.85). Mean follow-up period was 35.2 ± 29.1 weeks. Recurrence rate in the 5-FU group was 8.7% compared to 11.8% in the MMC group (recurrence risk ratio = 0.71, 95% CI 0.17-3.1, p = 0.7). One patient from the MCtreated group had corneoscleral melting. Other complications were mild and not sight threatening. In the prevention of pterygium recurrence, 5-FU appears to compare favorably with low-dose MMC when used as an adjuvant following pterygium excision and conjunctival autograft. Further studies are required to assess the long-term effect of using 5-FU in such cases.Item A sino-orbital scissors foreign body(2005) Bekibele, C. O.; Ogunleye, A. O. A.; Ashaye, A. O.; Baiyeroju, A. M.; Fasina, O.; Sandabe, M. B.; Aluko, A. A.The case of a sino orbital foreign body from the broken tips of a pair of scissors transversing the floor of the left orbit, left maxillary sinus and left nasal cavity, and which had been left in place for two years because of financial constrains, before its surgical removal without much sequel, is presented. The need for adequate radiological investigations in all cases of head and neck trauma as well as the institution of health insurance in developing / low income economies to cater for indigent patients especially in emergency situations is highlighted.