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Managing bite wounds in male a Mona monkey (cercopithecus mona)
(2012) Eyarefe, O. D.; Oguntoye, C.O.
This paper reports on the management of bite wounds inflicted on an adult male mona monkey by two other males in an attempt to mate the only female in the group. The deep laceration wounds which were at the left cranial thoracic and left caudal abdominal walls, the lateral aspect of the right thigh, the planter surface of the right fore limb and the right triceps muscle were managed with honey incorporated bandage dressings and delayed primary closure with sutures. The unique wound management procedure especially in wild life species,as well as the need to prevent group fight among wild life species in captivity especially mona monkeys through understanding of their social interactive structure formed the objectives of this report. Information acquisition by Zoo Veterinarians and managers, on social interaction among wild life species could help in preventing injuries, reducing cost of zoo animal keeping and conserving the few wild species presently available in our zoological gardens and game reserves
Wound healing potential of natural honey in diabetic and non-diabetic wistar rats
(2014-01) Eyarefe, O.D.; Ologunagba, F. M.; Emikpe, B.O.
The cutaneous wound healing effects of natural honey were compared in diabetic and non-diabetic rats. Thirty adult male Wistar rats (159g ± 31.5) where randomized into alloxan diabetics (n=15) and non-diabetic (n=15) groups. A 6mm full thickness biopsy punch wound was created on the nape of each rat under 2% xylazine (5mg/kg) and 5% ketamine (35mg/kg) anaesthesia. The wounds were contaminated with Staphylococcus aureus (108 Colony Forming Unit (CFU). Each group was then randomised into three subgroups: A [control, n=5], B (n=5) amikacin (0.8mg) and C (n=5) natural honey (0.1 ml) topical treatments. Wounds were evaluated at day: 3, 5, 7, 9, 11, 13, and 15 for wetness, oedema, hyperemia, granulation tissues, and contraction. Wounds of animals in the diabetic group showed significantly less (p>0.05) wetness compared with the non-diabetic group at days 3-5 (p=0.002) and 5-9, p=0.002 while the amikacin subgroup of the non-diabetic group showed non-significant but notable level of wetness at days 5-7. A significantly (p>0.05) more wound edge oedema was shown by the diabetic than the non-diabetic group at days 3-5 (p=0.000) with the trend being; control > amikacin > honey. The percentage of animals with wound edge oedema between days 3-5 in the non-diabetic group was honey (20%), amikacin (20%) and control (60%); and diabetic group was honey (40%), amikacin (100%) and Control (100%). Between days 5-7, 80% of wounds in both groups where without wound edge oedema except the control subgroups. Wounds of rats in the diabetic group were significantly more hyperaemic (p>0.05) at days 5-9 (p=0.001) and days 9-15 (p=0.000), with the trend being control > amikacin = honey. Wounds of rats in the non-diabetic groups healed with significantly more (p < 0.05) granulation tissues at days 5-9 (p=0.001) (honey = amikacin > control). Control group at days: 5-9 (p=0.001), 9-15 (p=0.000); amikacin at days: 5-9 (p=0.002), 9-15 (p=0.005); and honey at days: 5-9 (p=0.005) and 9-15 (p= 0.001). Differences in wound diameter (a reflection of wound contraction) were not significantly notable in both subgroups (p > 0.05) at various days of measurement except at days 3-5(p=0.008). Honey and amikacin were effective in enhancing cutaneous wounds healing in wistar rats studied. In diabetic rats, honey showed a promising result when compared to amikacin hence honey could be recommended for wound management of diabetic patient in human and animal hospitals
Wound healing potentials of aqueous pineapple (ananas comosus) extract - a preliminary report
(IDOSI Publications, 2016) Eyarefe, O.D.; Fabiyi, B.O.
The wound healing potentials of aqueous pineapple extract (Ananas comosus) were evaluated in eighteen (18) adult male albino rats (152±1.6g) randomized into 3 groups following a 2cm full-thickness skin incision induced on their dorsum. Group A wounds were treated twice daily with aqueous pineapple extract (APE)(n=6), B -silver sulphadiazine (SSD) (n=6) and C- phosphate buffer saline (PBS) (n=6). All wounds were evaluated conventionally with gross and histologic wound healing indices. Wound edge oedema, hyperaemia and exudation were prominent in all the groups between days 0 and 1 of the study. Wound edge oedema was, significantly less (p<0.05) on day 2 in APE (30%) compared with SSD(83%) and PBS(100%), (APE< SSD< PBS). Wound hyperaemia was markedly less, on days 2 and 3, though not significant (p > 0.05) (APE< SSD< PBS). Wound exudation was significantly less (p<0.05) on day 2 in APE compared to SSD and PBS (APE APE> PBS). The histologic changes observed on day 7 and 14 showed significant (P< 0.05) amount of Type 1 collagen, blood capillary regression and wound epithelialization in the APE and SSD groups compared with PBS group. Results of this study showed that aqueous pineapple extract possesses wound healing potentials compared to silver sulphadiazine and recommended for wound management in poor resource settings of third world countries

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