Veterinary Physiology Biochemistry & Pharmacology
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Item Ameliorating effect of guava (Psidium guajava) extract on adriamycin induced reproductive toxicities(University of Veterinary Medicine and Pharmacy In Kosice - The Slovak Republic, 2015) Ola-Davies, O. E.; Oloye, A. A.; Oyeyemi, M. O.This study was undertaken to investigate the protective effects of guava extract on Adriamycin induced reproductive toxicities. For this purpose, thirty adult male Wistar rats were randomly divided into 6 treatment groups. Group 1, the control, was administered distilled water while group 2 was treated with Adriamycin (ADR)(30 mg.m–2) alone. Groups 3, 4 and 5 were administered combinations of 30 mg.m–2 (ADR) and graded doses (125 mg.kg–1; 250 mg.kg–1; 500 mg.kg–1, respectively) of guava extract. Group 6 was treated with the extract (500 mg.kg–1) alone. The treatments were done for seven days with water and feed provided ad libitum. The effects of these treatments on the reproductive characteristics of the male Wistar rats were thereafter investigated. The results showed that the control group (1) had a significantly higher sperm count (96.25 ± 3.84 × 106 cells.ml–1) and motility (80.00 ± 4.08 %) compared to the other treatment groups (P < 0.05). Group 3 had a significantly lower sperm count (40.00 ± 0.00 × 106 cells.ml–1) compared with the group 4 (67.33 ± 4.81 × 106 cells.ml–1) and 6 (62.60 ± 3.09 × 106 cells.ml–1). Group 5 had the lowest percentage livability (50 %), which was significant when compared with the control group, but not significant compared with the other treatment groups (P < 0.05). Groups 3, 5 and 6 had over 20 % sperm cell abnormalities. Most prominent of the abnormalities in groups 3 and 5 were curved tails and curved mid pieces in group 6. This work showed that guava extract at 250 mg.kg–1 is safe and gave protective cover to ADR induced reproductive toxicities.Item Modulatory effects of guava extract on adriamycin (doxorubicin) induced toxicity in wistar rats(IDOSI Publications, 2016) Ola-Davies, O. E.; Azeez, O.Adriamycin, though, a drug of choice in cancer therapy, its use is associated with acute and chronic complications, which are capable of exacerbating the conditions of the patients. Thus, efforts are being directed at evaluating several compounds, antioxidants and natural products that are capable of ameliorating these complications whilst still retaining the potency and efficacy of Adriamycin as an anti cancer agent. The modulatory and ameliorative effects of methanol guava leaf extract (Psidium guajava Linn) against Adriamycin/Doxorubicin toxicity was evaluated in Wistar rats. Adriamycin (ADR) injection resulted in considerable liver and kidney damage as seen in the form of elevated liver enzymes, total protein as well as urea and creatinine levels in the blood. It also resulted in increases in the total triglyceride and cholesterol levels. The use of the extract alone on the other hand showed hepatoprotective and nephroprotective properties of guava leaf extract in that the above parameters were significantly lower than those of the untreated control. The protective effect of the extract against ADR toxicity was however limited to the liver. Effects which, may be due to the antioxidant and free radical scavenging properties of some of the components of the extract.