FACULTY OF VETERINARY MEDICINE

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Actualization of strategies for beef quality control in south western Nigeria
(2005-06) Olugasa, B. O.; Cadmus, S.I. B.; Atsanda, N.N.
A major private abattoir wd meat processing plant in south-westem Nigeria was studied in this article to determine its compliance with control over dissemination of parasitic and microbial diseases from beef to man. To ensure total quality control, a private veterinarian sourced for cattle on farms and supplied these to the abattoir. In addition, a public health veterinarian in government service at the abattoir carried out antemortem tests, postmortem inspection and removal of unwholesome cattle. Diseases such as fascioliasis, tuberculosis, cysticercosis and brucellosis were effectively controlled in this way. Hence, United African Company (UAC) Foods provides wholesome beef to the community
Actualization of strategies for privatized preventive veternary services to nomadic herdsmen in southern Nigeria.
(1997) Esuruoso, G. O.; Olugasa, B. O.
Acute sodium arsenite-induced hematological and biochemical changes in wistar rats: protective effects of ethanol extract of ageratum conyzoides
(Wolters Kluwer - Medknow Publications, 2016) Ola-Davies, O. E.; Akinrinde, A. S.
Background: Ageratum conyzoides L. (Asteraceae) is an annual herbaceous plant used in folklore medicine for the treatment of a wide range of diseases. Objective: To investigate the protective effect of the ethanol leaf extract of A. conyzoides (EEAC) against hematological, serum biochemical and histological alterations induced by Sodium arsenite administration to Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly assigned into four groups of five rats each. Group I received propylene glycol and Group II rats were given the (EEAC, 100 mg/kg b.w.) orally for 7 days. Group III were given a single oral dose of sodium arsenite (NaAsO2, 2.5 mg/kg b.w.). Animals in Group IV were pretreated with 100 mg/kg EEAC for 7 days followed by a single oral dose of sodium arsenite. Results: Arsenic exposure resulted in significant reductions (P < 0.05) in values of packed cell volume (PCV), hemoglobin concentration (Hb) and red blood cell (RBC) count, and elevation in total white blood cell (WBC) count with insignificant reductions in serum total protein, albumin, and globulin levels. Alterations in aspartate aminotransferase, alanine transferase, alkaline phosphatase, and gamma glutamyl transferase activities, as well as in serum levels of urea, creatinine, glucose, cholesterol, and triglyceride levels, were not statistically significant. EEAC significantly restored (P < 0.05) the PCV, Hb, RBC, and WBC as well as serum albumin, globulin, and total protein to normal values. Conclusion: The results of this study indicate that EEAC possess strong potentials to protect against toxicities induced by sodium arsenite.
African swine fever control in Ibadan, Nigeria: problems, needs and veterinary extension opportunities
(2008) Olugasa, B. O.
African swine fever (ASF) is a widely discussed disease in Ibadan, Nigeria, where high mortality losses occurred in outbreaks in the city between 2001-2006. To study the level to which ASF containment technologies were adopted and factors associated with adoption behavior, a sample of 60 pig farmers was selected from six local government areas in and near Ibadan. Essential data were collected using a questionnaire. Assessment criteria in forms of frequency, percentage, mean and product moment correlation coefficient were calculated. Results showed that the majority of pig farmers did not adopt ASF biocontainment technologies, since 86.7% (52/60) were at a low level of adoption behavior, 10% (6/60) at a medium level, and 3.3% (2/60) at a high level. A farmer’s income from piggery, knowledge of biocontainment technologies, and frequency of extension contact had positive and highly significant relationships (r 0.787) on levels of adoption. Specific needs and emerging opportunities for farmer participatory learning were indicated. It was recommended that Pig Farmers Association should constitute Farmer Field Schools, where the State Ministry of Agriculture and Natural Resources (MANR) would be involved in production of ASF virus-free pigs, and the current services by University-based officers to the early detection of pigs infected with the ASF virus will be optimized
Ameliorating effect of guava (Psidium guajava) extract on adriamycin induced reproductive toxicities
(University of Veterinary Medicine and Pharmacy In Kosice - The Slovak Republic, 2015) Ola-Davies, O. E.; Oloye, A. A.; Oyeyemi, M. O.
This study was undertaken to investigate the protective effects of guava extract on Adriamycin induced reproductive toxicities. For this purpose, thirty adult male Wistar rats were randomly divided into 6 treatment groups. Group 1, the control, was administered distilled water while group 2 was treated with Adriamycin (ADR)(30 mg.m–2) alone. Groups 3, 4 and 5 were administered combinations of 30 mg.m–2 (ADR) and graded doses (125 mg.kg–1; 250 mg.kg–1; 500 mg.kg–1, respectively) of guava extract. Group 6 was treated with the extract (500 mg.kg–1) alone. The treatments were done for seven days with water and feed provided ad libitum. The effects of these treatments on the reproductive characteristics of the male Wistar rats were thereafter investigated. The results showed that the control group (1) had a significantly higher sperm count (96.25 ± 3.84 × 106 cells.ml–1) and motility (80.00 ± 4.08 %) compared to the other treatment groups (P < 0.05). Group 3 had a significantly lower sperm count (40.00 ± 0.00 × 106 cells.ml–1) compared with the group 4 (67.33 ± 4.81 × 106 cells.ml–1) and 6 (62.60 ± 3.09 × 106 cells.ml–1). Group 5 had the lowest percentage livability (50 %), which was significant when compared with the control group, but not significant compared with the other treatment groups (P < 0.05). Groups 3, 5 and 6 had over 20 % sperm cell abnormalities. Most prominent of the abnormalities in groups 3 and 5 were curved tails and curved mid pieces in group 6. This work showed that guava extract at 250 mg.kg–1 is safe and gave protective cover to ADR induced reproductive toxicities.
Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in wistar rats through antioxidant defense system
(Taylor & Francis, 2017-07) Omobowale, T. O.; Oyagbemi, A. A.; Ajufo, U. E.; Adejumobi, A. O.; Ola-Davies, O. E.; Adedapo, A. A.; Yakubu, M. A.
Hepatotoxicity has been found to be one of the main side effects associated with doxorubicin (Dox) administration in cancer therapy. The aim of the present study was to examine the ameliorative effect of gallic acid (GA) in Dox-induced hepatotoxicity. Sixty male Wistar rats of 10 rats per group were used in this study and were randomly divided into 6 experimental groups (A–F). Rats in Group A served as the control group and received distilled water orally for 7 days; Group B was given Dox at 15 mg/kg bodyweight intraperitoneally (IP) on Day 8. Group Cwas given GA at 60 mg/kg body weight orally for 7 days + Dox at 15 mg/kg IP on Day 8. Group D was given GA at 120 mg/kg body weight orally for 7 days +Dox at 15 mg/kg IP on day 8. Rats in Groups E and F were administered GA alone at 60 and 120 mg/kg bodyweight orally for 7 days, respectively. Dox administration led to a significant reduction in hepatic reduced glutathione and nonprotein thiol (NPT) together with significant increase in hepatic malondialdehyde, hydrogen peroxide generation, superoxide dismutase, and catalase activity; hepatic glutathione peroxidase and glutathione-S-transferase activity were significantly inhibited in Dox-treated rats. The serum alanine aminotransferase (ALT), alkaline phosphatase, and total bilirubin concentrations were significantly elevated following Dox administration. Pretreatment with GA ameliorated Dox-induced hepatotoxicity and oxidative stress. The results suggest that GA may offer protection against hepatic damage in Dox cancer chemotherapy.
Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
(De Gruyter, 2017) Omobowale, T. O.; Oyagbemi, A. A.; Folasire, A. F.; Ajibade, T. O.; Asentiga, E. R.; Adejumobi, O. A.; Ola-Davies, O. E.; Oyetola, O.; James, G.; Adedapo, A. A.; Yakubu, M. A.
Background: The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats. Methods: Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A–F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i.p. Prior to this treatment, rats in Groups C and D had been treated orally with GA for 7 days at the dosage of 60 and 120 mg/kg, respectively. Animals from Groups E and F received only 60 and 120 mg/kg GA, respectively, which were administered orally for 7 days. Results: The exposure of rats to DOX led to a significant (p 0.05) decrease in the cardiac antioxidant defence system and elevation of creatine kinase myocardial band and lactate dehydrogenase. The electrocardiography results showed a significant decrease in heart rate, QRS, and QT-segment prolongation. GA alone improved the antioxidant defence system. Conclusions: The GA pretreatment significantly alleviated GA-associated ECG abnormalities, restored the antioxidant status and prevented cardiac damage.
Ameliorative effects of chloroform fraction of cocos nucifera L. husk fiber against cisplatin-induced toxicity in rats
(Wolters Kluwer - Medknow Publications, 2015) Adaramoye, O. A.; Azeez, A. F.; Ola-Davies, O. E.
Background: Cisplatin (Cis) is used in the treatment of solid tumors and is known to elicit serious side effects. Objective: The present study investigated the protective effects of chloroform fraction of Cocos nucifera husk fiber (CFCN) against Cis‑induced organs’ damage and chromosomal defect in rats. Quercetin (QUE), standard antioxidant, served as positive control. Materials and Methods: Thirty male Wistar rats were assigned into six groups and treated with corn oil (control), Cis alone, Cis + CFCN, CFCN alone, Cis + QUE, and QUE alone. QUE and CFCN were given at 50 and 200 mg/kg/day, respectively, by oral gavage for 7 days before the rats were exposed to a single dose of Cis (10 mg/kg, intraperitoneal) at the last 36 h of study. Results: Administration of Cis alone caused a significant (P < 0.05) increase in the levels of serum creatinine and urea by 72% and 70%, respectively, when compared with the control. The activity of serum aspartate aminotransferase was significantly (P < 0.05) increased while alanine aminotransferase and alkaline phosphatase were insignificantly (P > 0.05) affected in Cis‑treated rats. Furthermore, the activities of hepatic and renal catalase, superoxide dismutase, glutathione S‑transferase, glutathione peroxidase, and levels of reduced glutathione were significantly (P < 0.05) decreased in Cis‑treated rats with concomitant elevation of malondialdehyde. Cis exposure increased the frequency of micro nucleated polychromatic erythrocytes (mPCE) by 92%. Pretreatment with CFCN inhibited lipid peroxidation, enhanced the activities of some antioxidative enzymes and reduced the frequency of mPCE. Conclusions: Chloroform fraction of CFCN may protect against organs damage by Cis. Further studies are required to determine the component of the plant responsible for this activity.
Ameliorative effects of Musa sapientum peel extract on acetic acid-induced colitis in rats
(The Egyptian German Society for Zoology, 2016) Adegoke, G. A.; Onasanwo, S. A.; Eyarefe, O. D.; Olaleye, S. B.
Ameliorative effects of Musa sapientum peel extract (MSPE) were studied on Acetic Acid (AA)-induced colitis in rats. From a dose response study, the effective and yet, safe for the treatment of AA-induced colitis in rats was determined, and also, a further study was carried out to determine the effective fraction(s) of MSPE that will be useful in the treatment of AA induced colitis in rats. Colitis was induced with 0.2 ml of 6% acetic acid through a lower abdominal laparotomy. Treatment with graded doses of methanolic extract of dried peel of Musa sapientum (MS) (50, 100 and 200 mg/kg) for 7 days in AA induced colitis in rats showed 50 mg/kg as an optimal effective dose for the healing of AA induced colitis in rats. This dose (50 mg/kg) was further studied with fractions of MSPE in comparison to a standard drug (sulfasalazine) of the same dose (50 mg/kg) on AA induced colitis in rats for 18 days. Colitis was assessed using stool consistency, macroscopic gross score and histological studies. Normal stool consistency was seen early in treated animals as compared with control; MS peel (crude extracts and fractions) significantly reduced macroscopic and histologic colon tissue damage in a manner similar to that of sulfasalazine. The results from these findings suggests that MSPE fractions of ethyl acetate and methanol may be effective in reducing both macroscopic and histological damage in a manner similar to sulfasalazine, and that it may be helpful in the treatment of colitis
Analysis and evaluation of mortality losses of the 2001 African swine fever outbreak, Ibadan, Nigeria
(2007-08) Babalobi, O. O; Olugasa, B. O.; Oluwayelu, D.O.; Ijagbone, I. F.; Ayoade, G. O.; Agbede, S. A.
The mortality losses of pigs of various age groups affected by the 2001 African swine fever outbreak in Ibadan Nigeria were analyzed and evaluated. Thirty one thousand nine hundred and sixteen (31,916) pigs on three hundred and six (306) farms reported by the Pig Farmers Association of Nigeria and the State Ministry of Agriculture and Natural Resources were involved. Gross mortality was ninety one percent (91%), while age group mortality ranged from 75.9% (growers), 83.1% (weaners), 91.2% (finishers) and 99.8% (piglets); to 100.0% in gilts, sow and boars. Losses were estimated to worth nine hundred and forty one thousand, four hundred and ninety one dollars, sixty seven cents (US $941,491.67). Highest financial loss was from sows (29.5% of total loss), followed by gilts (16.6%), finishers (15.2%), weaners (10.7%), boars (10.6%), growers (10.6%) and piglets (8.2%). Average mortality loss per farm of $3076.77 was of great financial and socioeconomic consequences for a developing country like Nigeria with a low Gross Domestic Product figures. In conclusion, the need to immediately revisit and take recommended actions on the 1998 Report of the FAO Consultancy Mission to Nigeria on Control and Eradication of an Outbreak of African swine fever in Western Nigeria is stressed
Animal health management perspectives of rural livestock farmers in Southwest Nigeria: the place of community based animal health workers
(2010) Idowu, O. S.; Babalobi, O. O.
A case study of a typical community based rural livestock production system in South-west Nigeria was undertaken using participatory epizootiology (PE) to understand local preferences for animal health management practices and observe if there is any justification or place for community based animal health workers (CBAHW ) in rural livestock health and production management. Sheep and goats were the major animals kept by 46.7% of the respondents, followed by chicken (29.3%), dogs (13.3%), ducks (8.0%) and pigs (2.7%). The major health and production problems identified were Pestes des petit ruminants (PPR) (30.0% of respondents), mange (23.0%) and crop destruction (20.0%); while cannibalism by hawks/eagle was the major problem of poultry production as highlighted by rural women (15%). While more respondents (42.7%) rate modern animal health practitioners as more effective than Fulani pastoralists healers (33.67%) and indigenous local healers (25.0%), modern animal health practitioners were described as least truthful/ unreliable (91.7%), less available (91.7%), most expensive (66.7%) and inaccessible (25.0%). On the other hand, indigenous local healers were rated as very available and more accessible (66.7%) while Fulani pastoralist healers were rated as more available and ready to provide veterinary services (58.3%) compared to indigenous local healers (33.3%) and modern animal health practitioners (8.3%). These results are similar to those obtained in other African countries. In conclusion, despite the prevailing professional apathy to the CBAHW concept by influential veterinary authorities in Nigeria, health issues highlighted by the community-based rural livestock farmers could be adequately addressed by CBAHW.
Animal health management: principles and practice
(Centre for General Studies, 2019) Eyarefe, O.D.; Jeremiah, O. T.
Ano-rectal malformations in pigs: a report of a striking case in an eight-week-old piglet (a case report)
(2011) Eyarefe, O. D.; Abiola, J. O.; Oguntoye, C. O.; Ayoade, G. O.
Anorectal malformations are rare congenital disorders in animals. In swine, atresia ani occurs with an incidence of 0.1—1.0 % and it is the most important cause of intestinal obstruction in that species. This paper reports a striking case of atresia ani et recti in an eightweek- old piglet. The surgical management and preventive measures are discussed
Anthelmintic efficacy of the aqueous crude extract of Euphorbia hirta Linn in Nigerian dogs
(2005) Adedapo, A. A.; Shabi, O. O.; Adedokun, O. A.
The anthelmintic efficacy of the aqueous crude extract of Euphorbia Itirta Linn was studied in 20 Nigerian dogs that were naturally infected with nematodes. They were randomly divided into 4 groups. A, B. C and D. Groups A and B each comprised 4 dogs while groups C and D comprised 6 dogs each. Group A animals were untreated, while those in group B were treated with proprietary anthelmintic (Mebendazole). Groups C and D animals were treated with aqueous crude extracts of E. hirta using intramuscular and oral routes, respectively. Two weeks after treatment, blood and faecal samples were collected to evaluate haematological values and faecal egg counts, respectively. The procedure was repeated two weeks later. Results of this study show that the aqueous crude extracts of E. hirta after its administration into local dogs produced a significant increase (P< 0.05) in PCV, RBC. l ib cone.. TWBC and lymphocyte counts. The faecal egg counts also showed a remarkable and significant reduction in the levels of the identified helminths. The reduction in faecal egg counts was more pronounced with the extract administered through the oral route when compared with the intramuscular route. The effects of the plant extracts were broad spectrum in action. The phenol compound present in the plant extract could have caused reduction in worm load through this same mechanism that culminates in exhaustion and death ofworms. Since the aqueous crude extract of £. hirta significantly reduced the faecal egg count of the helminths, it could serve as an anthelmintic agent
Anthropophilic nature of the brown dog tick, rhipicephalus sanguineus in Ibadan, Nigeria
(Tropical Veterinarian, 2001) Sadiq, N .A.; Adejinmi, J. O.; Adedokun, A.O.
A case of human infestation by the brown dog tick, Rhipicephalus sanguineus (Latereille, 1806) is reported from a reclaimed area of land for human dwellings. The infestation is attributed to nonavailability of rodents, other game animals and reduced number of dogs used for gaming.
Anti-inflammatory and analgesic effects of methanol extract of stellaria media (L.) Vill leaf
(2012-01) Oyebanji, B. O.; Saba, A. B.; Oridupa, O. A.
The anti-inflammatory and analgesic effect of the methanolic extract of Stellaria media (L.) Vill leaf was studied using albumen-induced paw oedema and formalin-induced paw lick in rats as the anti-inflammatory test models; acetic acid-induced writhing, hot plate and tail flick tests in mice as the analgesic models. Three groups of five rats or mice each were administered orally with the leaf extract of S. media at 100mg/kg, 300mg/kg or 500mg/kg body weight respectively. A fourth group was administered with Indomethacin (5mg/kg b.w) and distilled water (10mls/kg b.w) for the control group. The extract of S. media dose-dependently, significantly (p<0.05) inhibited egg albumen-induced paw oedema as effectively as Indomethacin. The late phase of the formalin response was also inhibited. The extract at 300mg/kg body weight produced a significant (p<0.05) inhibition of the acetic acid-induced abdominal constrictions in mice compared to the control group and mice administered with indomethacin. The analgesic property of the extract was also exhibited in the tail flick test as the extract significantly (p<0.05) increased the tolerance of the mice to pain relative to indomethacin-treated mice. The methanolic extract of S. media showed potent peripherally and centrally mediated anti-inflammatory and analgesic properties. The analgesic effect appears mediated through inhibition of release of histamine, serotonin and kinins, prostaglandin, cyclooxygenase and slow reacting substance.
Antibody levels against rabies among occupationally exposed individuals in a Nigerian University
(2010) Olugasa, B. O.; Odeniyi, A. O.; Adeogun, A. O.|; Adeola, O.A
The authors investigated the levels of antiglycoprotein antibodies against rabies virus in the sera of occupationally exposed humans at the University of Ibadan, Nigeria. A quantitative indirect enzyme‐linked immunosorbent assay (ELISA) was used to detect rabies virus anti‐glycoprotein antibodies in sera from 20 zoological garden workers, 20 veterinarians and 30 clinical veterinary students at the University of Ibadan. The sera were obtained between September 2008 and February 2009. Of these 70 healthy individuals, 29 (41.4%) consisting of 15 zoological garden workers (75.0%), 13 veterinarians (65.0%) and 1 veterinary student (3.3%) were immune to rabies virus (antibody titre >0.5 equivalent units per ml), while 41 (58.6%) were not immune. The prevalence of rabies anti‐glycoprotein antibody was higher within the older segment of the study population than among the younger veterinary students. Almost all those who had spent at least 10 years on the job had higher levels of rabies vaccination compliance and were immune. Our results indicated that there is low anti‐rabies immunity among occupationally exposed individuals at the University of Ibadan. There is a need for a complete course of primary and booster vaccinations of professionals exposed to the rabies virus. The impact of these results on rabies control in Nigeria is discussed.
Anticlastogenic properties of methanolic extract of cnestis ferruginea leaves
(Faculty of Pure and Applied Sciences, LAUTECH, Ogbomoso, Nigeria, 2006) Badmus, J. A.; Odunola, O. A.; Ola-Davies, O. E.; Adisa, R. A.
The inhibitory activity of methanolic extract of Cnestis ferruginea was investigated in hone marrow cells of mice using micronucleus assay. The mice were fed with the extracts at two different concentrations (100 and 200mg/kg body weight) white control mice were fed with corn oil for six days ad libitum. On the seventh day the mice were administered a single dose of sodium arsenile (2.5mg/kg) and sacrificed after 24hrs. Bone marrow smear were prepared for Observation of claslogenic effect. Results show micronuclei formation in the polychroniatic erythrocyte (PCEs) in the Sodium arsenite treated mice. Claslogenecity induced by sodium arsenile was significantly reduced in mice pretreated with the extract al 100mg/kg body weight while more significant reduction was noted at 200mg/kg body weight. The result indicates a dose dependent relationship of the inhibitory activity of the extract against sodium arsenile induced clastogenecity.
Antihelminthic and anticoccidial effects of vernonia amygdalina in goats
(Global Researchers Journal, 2014) Adediran, O. A.; Uwalaka, E. C.; Kolapo, T. U.
The deteriorating and adverse effect of chemoprophylaxis and chemotherapy in livestock production has been well documented, however, not many alternatives with minimal or no side effects are available for treatment and control of parasite infections. Vernonia amygdalina, also known as bitter leaf, has been reported to have various medicinal properties, however, its antihelminthic and anticoccidial properties in goats has not been investigated despite anecdotal reports of its antidiarrhoiec effects in the specie. 20 goats were bought from various households, stabilized, divided into treatment group of fifteen and control group of five. They were fed on pasture and allowed to acquire natural parasite infection that was confirmed by feacal count and culture. The treatment groups were fed with V amygdalina leaves and young stalk ad libitum for two days while the control group was denied access to the plant. Feacal samples were collected on days 1, 2, 4 and 7, post treatment and sent to laboratory for analysis. The ingestion of Vernonia amygdalina was effective in the clearance of helminth eggs and coccidian cysts with an efficacy of 100% for helminths and 99.4% for coccidia. Five goat owners with herds ranging between five to twelve in number diagnosed with helminth infecton were asked to feed V amygdalina leaves to the goats once a week. All the goats were free of helminth infection within the period of four weeks that they were monitored. The effect of Vernonia amygdalina on helminth and coccidian parasites in goats has corroborated findings by other authors in other animal species and man. The plant provides an alternative and natural antiparasitic agent for goat heminth and coccidian that is environment friendly and without the effect of chemical residues. Further, studies on the dose may have to be carried out
Application of geographical information systems to assess the risk of trypanosomosis in Apete, Ibadan
(2001) Oguamanam, L.; Babalobi, O. O.; Fabiyi, O.
Geography information System (GIS) was applied to assess the risk of trypanosomosis at Apete area, Ibadan, Nigeria where the University of Ibadan’s Veterinary Teaching Hospital has a satellite station. Primary data were collected from physical field observations and interviews with residents and community leaders in the area between September 2000 and March 200.1 Secondary data sources included maps from Oyo State ministry of Land, Housing and Survey, International Livestock Research Institute ILRI. Internet Search and consultation with GIS personnel at the Geography Department of the University of Ibadan. Data analysis was done at DISEG Niq Ltd Ibadan. Software used included Arcview GIS Version 3.1® Atlas GIS® and Arc info GIS Microsoft Word 98® was used for typing Epizootological criteria chosen included the Forest Reserve Area Rivers and An-mal Host locations at Apete area. Results classified Apete area into high risk and medium risk areas and highlight the potential of GIS for landscape epizootological research. Recommendation are made for provision of relevant database of high quality which should be regularly updated. There is need for collaborative efforts with the GIS unit of Geography Department of the University.