FACULTY OF VETERINARY MEDICINE
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Item Vital reproductive indices in non gravid female rabbits treated with crude ethanol extract of spondias mombin(University of Veterinary Medicine and Pharmacy In Kosice - The Slovak Republic, 2013) Oloye, A. A.; Oyeyemi, M. O.; Ola-Davies, O. E.; Ajayi, O. I.; Ajayi, A. R.Ten female Chinchilla breed of rabbits with a mean weight of 1.65 ±0.06 kg, were randomly divided equally into a treatment and a control group. The treatment group received orally 800 mg.kg1 of an ethanol extract of Spondias mombin for fourteen days. The control group received only distilled water utilizing the same method of administration. The females were kept separately away from males. Assays of the reproductive hormones before and after treatment with the extract in the treatment group were done. Both groups were sacrificed after fourteen days of oral administration and their reproductive tracts carefully examined. The studies revealed the normal morphology of ovaries, oviduct, uterine horns, and uterine body in both groups. The histological sections of different reproductive segments were normal. Left and right ovaries appeared to show marked oogenesis in the treated group going by the larger number of follicles observed compared to the control. The body weight adjusted mean paired ovarian diameter of the control group (0.51 +0.02cm) was significantly (P<0.05) different from the treated animals (0.41 ±0.39 cm) but this did not translate into a significant difference in the paired ovarian weights. The body weight adjusted lengths, widths and weights of other parts of the reproductive tracts did not differ significantly comparing the treated and control groups, except for the length of the right uterine horn and the weight of the right oviduct. The studies showed that all of the hormones did not change significantly, comparing the pre and post treatment in the treated group. It was concluded that 800 mg.kg-' of ethanol extract of Spondias mombin appeared to favour folliculogenesis in non-gravid rabbits and resulted in no observed pathological effects on the entire reproductive tract of the rabbit.Item Hormonal variation in gravid does after oral treatment with crude ethanol extract of spondias mombin(2013) Oloye, A. A.; Oyeyemi, M. O.; Ola-Davies, O. E.; Olurode, S. A.; Ajayi, A. R.Twelve mixed breed gravid rabbits weighing between 4.5-6.0kg body weights were randomly selected to study the effect of oral treatment with leaf ethanol crude extract of Spondias mombin on sex steroid hormones. Six were administered 800mg/kg of the extract while six were administered distilled water once every day for 7 days at day 14 of gestation. Blood samples were collected before commencement of treatment and 7 days post treatment in both groups. This was repeated 24 hours after parturition in the control group only. Sera from blood samples were analyzed for sex hormones concentration using ELISA. Results revealed that mean progesterone concentration significantly increased in the treatment group from pre-treatment value of 5.4±0.30ng/ml to post treatment value of 9.5±0.30ng/ml compared to significant decrease from 5.1±0.20ng/ml to 2.5±0.50ng/ml in the control group (P<0.05). All other hormones had no significant changes in both groups comparing pre and post treatment except FSH which significantly reduced from 3.1±0.08mIU/ml to 2.2±0.10mIU/ml in control group. Abortion was observed in the treatment group on days 22 and 23 of gestation, between 24 and 48 hours post treatment while all the rabbits in control group kindled a mean value of 5.7±0.68 kits at a mean gestation period of 30.3±0.33days. The study concluded that crude ethanol extract of Spondias mombin has abortifacient tendency by manipulation of steroids important in gestation.