FACULTY OF VETERINARY MEDICINE

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    Evaluation of the “antidotal” potential of mangifera indica L. leaves extract on sodium arsenate exposed male wistar rats using some biochemical markers
    (Faculty of Science, University of Peradeniya, Sri Lanka, 2017) Ola-Davies, O. E.; Biobaku, K. T.; Okediran, B. S.; Adah, A. S.
    Abstract: In order to evaluate the antidotal potential of Mangifera indica L leaves extract on sodium arsenate exposed male Wistar rats using some biochemical markers, forty-two apparently healthy male Wistar rats (weight range 120-160 g) were used in the study. The animals were randomly separated into six groups. Other than groups “A” (non-exposed control) and “B” (exposed control), groups; C, D, E, and F respectively were treated with different dosages of Mangifera indica L extract viz., l00 mg/kg and 200 mg/kg extract. Volumes of extract administered did not exceed 0.2 ml regardless of the body weight of the animal respectively. Some biochemical parameters assessed were: serum protein, albumin, conjugated bilirubin, unconjugated bilirubin (ICB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP),gamma-glutamyl transferase (GGT), urea, creatinine, creatine kinase (CK), lactate dehydrogenase (LDH),acid phosphatase, prostatic phosphatase, serum lipid profile, that is total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and the hormones, testosterone and luteinizing hormone levels. Group “B” had significantly (P<0.05) higher activities for AST, GGT, CK, LDH and higher cholesterol concentration when compared to Mangifera indica treated groups and to the non-exposed control. Testosterone and LH were significantly (P<0.05) lower in group “B” unlike the Mangifera indica treated groups and group “A”. This observation could be attributed to adverse effect of toxicosis on exposure to animals in group “B”. Antitodal property of the extract, due to one or more of its phytochemicals such as flavonoids, tannins alkaloid and anthraqunones could be the most probable reason for potential therapeutic potential. Conclusively, this observation gives credence to its cytoprotective and antitodal properties.
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    Ameliorating effect of guava (Psidium guajava) extract on adriamycin induced reproductive toxicities
    (University of Veterinary Medicine and Pharmacy In Kosice - The Slovak Republic, 2015) Ola-Davies, O. E.; Oloye, A. A.; Oyeyemi, M. O.
    This study was undertaken to investigate the protective effects of guava extract on Adriamycin induced reproductive toxicities. For this purpose, thirty adult male Wistar rats were randomly divided into 6 treatment groups. Group 1, the control, was administered distilled water while group 2 was treated with Adriamycin (ADR)(30 mg.m–2) alone. Groups 3, 4 and 5 were administered combinations of 30 mg.m–2 (ADR) and graded doses (125 mg.kg–1; 250 mg.kg–1; 500 mg.kg–1, respectively) of guava extract. Group 6 was treated with the extract (500 mg.kg–1) alone. The treatments were done for seven days with water and feed provided ad libitum. The effects of these treatments on the reproductive characteristics of the male Wistar rats were thereafter investigated. The results showed that the control group (1) had a significantly higher sperm count (96.25 ± 3.84 × 106 cells.ml–1) and motility (80.00 ± 4.08 %) compared to the other treatment groups (P < 0.05). Group 3 had a significantly lower sperm count (40.00 ± 0.00 × 106 cells.ml–1) compared with the group 4 (67.33 ± 4.81 × 106 cells.ml–1) and 6 (62.60 ± 3.09 × 106 cells.ml–1). Group 5 had the lowest percentage livability (50 %), which was significant when compared with the control group, but not significant compared with the other treatment groups (P < 0.05). Groups 3, 5 and 6 had over 20 % sperm cell abnormalities. Most prominent of the abnormalities in groups 3 and 5 were curved tails and curved mid pieces in group 6. This work showed that guava extract at 250 mg.kg–1 is safe and gave protective cover to ADR induced reproductive toxicities.