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    Mycobacterium bovis in a bull on a university farm: public health implications
    (2020) Tijani,M.O; Adesokan,H.K; Kasali,O.B; Cadmus,S.I
    An unsuspected bull in a private herd of forty cattle heads in south-western Nigeria died suddenly following three days´ treatment against tick infestation. Post-mortem findings revealed multifocal widespread nodules in all lobes of the lungs with markedly enlarged lymph nodes. Isolate from cultured sample was subjected to spoligotyping which confirmed the isolate as Mycobacterium bovis (M. bovis) belonging to the SB1027 clade with octal number 676773776277600 (Figure 1). This finding has implications on the health of the cattle handlers considering aerosol inhalation of disseminated bacilli from the lungs of the infected bull through cough sprays. Routine screening of cattle for tuberculosis is therefore emphasized.
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    Phenotypic Characterization And Spoligotype Profiles Of Mycobacterium Bovisisolated From Unpasteurized Cows’ Milk In Ibadan, Nigeria.
    (2007) CADMUS, S.I.B.; ADESOKAN, H.K.
    A pilot study was carried out to screen for the presence of Mycobactcria in unpasteurized milk from cows mcant for sale at the cattle market in the mclropolitan city of Ibadan. South-western Nigeria. Fifty three milk samplcs were cultured using 7H11 -Middlebrook media while nitrate and niaein biochemical tests were carried out initially to classify the isolated Mycobacteria specics and the results were later' confirmed by spoligotyping. In all, Mycobacterium bovis were isolated from 6 (11.3%) milk samples. The detected spoligotypes obtained were NI, N6, N9, NI6. and N28 (two isolates). After comparison with the "Mycobacterium bovis Spoligotype Database” (www.mbovis.org), spoligotypes NI. N6, and N16 were found to have been already documented (N1=SB0944; N6=SBI027: NI6=SB0951). while N9 and N28 were relative!)' new strains and undocumented. The public health implication of these findings is that humans are at great risk of exposure to infection with M. bovis through the consumption of unpasteurized milk from cattle through the food chain.
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    Meat inspection and cultural isolation of mycobacteriaas predictors of bovine tuberculosis in Ibadan
    (2007) Cadmus, S.I.B.; Alonge, D.O.; Adesokan, H. K.
    In order to ascertain the effectiveness of meat inspection as against the conventional culture method in the confirmation of tuberculosis in cattle slaughtered at Bodija abattoir. Ibadan; a study to assess these two methods in their ability to diagnose bovine tuberculosis was carried out. In all. 290 cattle were inspected at the abattoir out of which 182 had military nodules and granulomatous tubercles in the different organs and their associated lymph nodes which are suggestive of tuberculosis. One hundred and fifty-nine (54.8%) animals were confirmed to have tuberculosis based on the mycobacterial culture. The sensitivity and specificity results of the postmortem examination vis-a vis the culture were 100% and 82.4% respectively; while the Positive Predictive Value (PPV) and the Negative Predictive Value (NPV) were 87.4% and 100% respectively. This study therefore confirms that with proper meat inspection. a large proportion of tuberculosis cattle can be identified at postmortem. Hence. more emphasis should be directed at the improvement of meat inspection Services in Nigeria since there are no available laboratory facilities for the diagnosis of bovine tuberculosis in the abattoirs