Veterinary Medicine

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Author: search.filters.author.Ojo, O. E.

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    Multidrug resistant verocytotoxin-producing Escherichia coli O157:H7 in the faeces of diarrhoeic and non-diarrhoeic dogs in Abeokuta, Nigeria
    (Faculty of Veterinary Medicine, University of Zagreb, 2014) Ojo, O. E.; Bello, A. O.; Amosun, E. A.; Ajadi, R. A.
    Verocytotoxin-producing Escherichia coli (VTEC) 0157:H7 is a predominant cause of haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS) in humans. To assess thè role of dogs as a possible source oftransmission ofVTEC 0157:H7 to humans, thè faeces of diarrhoeic (31) and non-diarrhoeic (63) dogs were examined for thè presence of thè organista. Escherichia coli 0157:H7 was isolated from 22 (23.4%) out of 94 samples examined. The organism was detected in 5 (16.1%) out of 31 diarrhoeic faeces and 17 (26.9%) out of 63 non-diarrhoeic faeces, but thè difference was not statistically significant (P>0.05). All thè E. coli 0157:H7 isolates produced one or both of verocytotoxin 1 and 2 (VT1 and VT2). Verocytotoxin 1 (VT1) was detected in 10 (45.5%) out of 22 isolates, VT2 in 8 (36.4%), while both toxin types were detected in four (18.2%) isolates. Sixteen (72.7%) out of 22 isolates were resistant to at least three antimicrobials from different classes, while 18 distinct antimicrobial resistance pattems were observed among thè isolates. The isolates showed resistance to ampicillin (86.4%), chloramphenicol (36.4%), ciprofloxacin (4.5%), gentamicin (18.2%), kanamycin (68.2%), nalidixic acid (22.7%), neomycin (40.9%), norfloxacin (9.1%), streptomycin (63.6%), sulphamethoxazole/ trimethoprim (63.6%) and tetracycline (77.3%). The present study showed that diarrhoeic and non-diarrhoeic dogs may serve as potential sources of multi-drug resistant VTEC 0157 :H7 transmissible to humans.
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    Multidrug resistant verocytotoxin-producing Escherichia coli O157:H7 in the faeces of diarrhoeic and non-diarrhoeic dogs in Abeokuta, Nigeria
    (Faculty of Veterinary Medicine, University of Zagreb, 2014) Ojo, O. E.; Bello, A. O.; Amosun, E. A.; Ajadi, R. A.
    Verocytotoxin-producing Escherichia coli (VTEC) 0157:H7 is a predominant cause of haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS) in humans. To assess thè role of dogs as a possible source oftransmission ofVTEC 0157:H7 to humans, thè faeces of diarrhoeic (31) and non-diarrhoeic (63) dogs were examined for thè presence of thè organista. Escherichia coli 0157:H7 was isolated from 22 (23.4%) out of 94 samples examined. The organism was detected in 5 (16.1%) out of 31 diarrhoeic faeces and 17 (26.9%) out of 63 non-diarrhoeic faeces, but thè difference was not statistically significant (P>0.05). All thè E. coli 0157:H7 isolates produced one or both of verocytotoxin 1 and 2 (VT1 and VT2). Verocytotoxin 1 (VT1) was detected in 10 (45.5%) out of 22 isolates, VT2 in 8 (36.4%), while both toxin types were detected in four (18.2%) isolates. Sixteen (72.7%) out of 22 isolates were resistant to at least three antimicrobials from different classes, while 18 distinct antimicrobial resistance pattems were observed among thè isolates. The isolates showed resistance to ampicillin (86.4%), chloramphenicol (36.4%), ciprofloxacin (4.5%), gentamicin (18.2%), kanamycin (68.2%), nalidixic acid (22.7%), neomycin (40.9%), norfloxacin (9.1%), streptomycin (63.6%), sulphamethoxazole/ trimethoprim (63.6%) and tetracycline (77.3%). The present study showed that diarrhoeic and non-diarrhoeic dogs may serve as potential sources of multi-drug resistant VTEC 0157 :H7 transmissible to humans.
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    Antimicrobial resistance among commensal Escherichia coli from cattle faeces and beef in Ibadan, Nigeria
    (Academic Journals, 2012) Amosun, E. A.; Ojo, O. E.; Alao, I. K.; Ajuwape, A. T. P.
    Commensal bacteria contribute to the distribution and persistence of antimicrobial resistance in the environment. This study monitored antimicrobial resistance in commensal Escherichia coli from the faeces of on-farm and slaughter cattle and beef. A total of 342 (89.5%) E. coli isolates were obtained from 382 samples. Isolation rate of E. coli was 90.0% in on-farm cattle, 87.1% in slaughter cattle and 92.2% in beef. Overall, the isolates showed resistance to amoxicillin (97.9%), ampicillin (97.9%), cefuroxime (25.1%), chloramphenicol (69.3%), ciprofloxacin (11.7%), cotrimazole (45.9%), erythromycin (59.4%), gentamycin (36.5%), nalidixic acid (27.2%), nitrofuratoin (54.9%), norfloxacin (21.1%), ofloxacin (14.0%), streptomycin (78.9%) and tetracycline (33.9%). There were no significant differences in antimicrobial resistance of E. coli from the different sample types. Only four (1.2%) of the 342 isolates were susceptible to all antimicrobial agents, while 338 (98.8%) were resistant to at least one of the tested antimicrobial agents. Multi-drug resistance to three or more antimicrobials was observed in 321 (93.9%) of all the isolates. Forty-one resistance groups were observed in on-farm cattle, 30 in slaughter cattle and 34 in beef. All the 30 resistance groups found in slaughter cattle were also present in on-farm cattle and beef. ‘AmoAmpChlEryNitStr’ and ‘AmoAmpChlStr’ were the predominant resistant patterns. This study confirmed on-farm and slaughter cattle as important sources of antimicrobial resistant E. coli transmissible to humans through beef.