FACULTY OF VETERINARY MEDICINE

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Subject: search.filters.subject.Haematology

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    Haematological and serum biochemical variables in rats treated with ethanol extract of the root of moringa oleifera
    (Biomedical Communications Group, Ibadan, 2014-01) Ola-Davies, O. E.; Olukole, S. G.; Amoo, O. A.
    The haematology and serum biochemical effects of oral administration of the ethanolic extract of the root of Moringa oleifera at 50, 100 and 150 mg/kg were investigated in 30 mated female Wistar rats. The rats were assigned into five groups of six rats each. Group A was given 50mg/kg of the extract; group B, 100mg/kg; group C, 150 mg/kg; group D, 0.2ml of corn oil; and group E, 0.2ml of distilled water. Groups D and E, corn oil and distilled water treatment groups respectively, served as the controls while groups A, B and C were the treatment groups. There was no significant difference (P>0.05) between the two control groups and the treatment groups for the RBC, WBC, PCV, MCV, MCH and MCHC and Hb. However, the mean lymphocyte values for groups B and C were significantly different (P<0.05) from those of group A as well the two control groups. The total protein, albumin, globulin and A/G ratio showed no significant difference (P>0.05) between the two control groups and the treatment groups. There were no significant differences (P>0.05) in the values of AST, ALP, creatinine, urea, GGT, glucose, cholesterol and ALT between the treatment groups and the control groups. It can therefore be concluded that oral administration of ethanolic extract of the root of M. oleifera is harmless to the rats since no adverse effects were detected in haematological and serum biochemical investigations
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    Modulatory effects of ethanol extract of Spondias mombin leaves on sodium arsenite induced toxicity
    (2013) Ola-Davies, O. E.; Adebiyim, O. E.; Ewete, A.
    This study evaluated the ameliorative potential of aqueous extract of Spondias mombin against arsenic-induced toxicity in the rat brain. Forty-five albino rats were randomly divided into nine groups of 5 rats each. Groups A, C and E were administered S. mombin leaf extract alone in graded doses of 100, 200 and 300 mg/kg body weight respectively for 7 days. Groups B, D and F were administered the extract at 100, 200 and 300 mg/kg respectively for 7 consecutive days in a single oral dose by gavaging before oral administration of sodium arsenite (NaAs02) (2.5mg/kg) on day 7. Groups G and H served as the negative control groups and received 0.2 ml diluted propylene glycol (vehicle for the extract) and distilled water respectively. Group I received distilled water for 7 consecutive days and 2.5mg/kg NaAs02 as a single oral dose on the 7th day. Heamatological (packed cell volume, red blood cell count, haemoglobin, white blood cell count, platelets, and neutrophils count) and biochemical parameters (serum alkaline phosphatase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase) urea and Creatinine were evaluated in all animals. Clastogenecity activity was evaluated by studying micronuclei formation in polychromatic erythrocyte cells in bone marrow. Pretreatment with S. mombin significantly reduced the elevated serum levels of liver enzymes and reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in rat bone marrow intoxicated with arsenic. Histological examinations showed that the extract at tested dosages protected against NaAs02-induced liver damage. Our findings suggest that the leaf extract of S. mombin possesses a remarkable ameliorative effect against sodium arsenite induced toxicity in albino rats.
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    Anthelmintic efficacy of the aqueous crude extract of Euphorbia hirta Linn in Nigerian dogs
    (2005) Adedapo, A. A.; Shabi, O. O.; Adedokun, O. A.
    The anthelmintic efficacy of the aqueous crude extract of Euphorbia Itirta Linn was studied in 20 Nigerian dogs that were naturally infected with nematodes. They were randomly divided into 4 groups. A, B. C and D. Groups A and B each comprised 4 dogs while groups C and D comprised 6 dogs each. Group A animals were untreated, while those in group B were treated with proprietary anthelmintic (Mebendazole). Groups C and D animals were treated with aqueous crude extracts of E. hirta using intramuscular and oral routes, respectively. Two weeks after treatment, blood and faecal samples were collected to evaluate haematological values and faecal egg counts, respectively. The procedure was repeated two weeks later. Results of this study show that the aqueous crude extracts of E. hirta after its administration into local dogs produced a significant increase (P< 0.05) in PCV, RBC. l ib cone.. TWBC and lymphocyte counts. The faecal egg counts also showed a remarkable and significant reduction in the levels of the identified helminths. The reduction in faecal egg counts was more pronounced with the extract administered through the oral route when compared with the intramuscular route. The effects of the plant extracts were broad spectrum in action. The phenol compound present in the plant extract could have caused reduction in worm load through this same mechanism that culminates in exhaustion and death ofworms. Since the aqueous crude extract of £. hirta significantly reduced the faecal egg count of the helminths, it could serve as an anthelmintic agent