FACULTY OF VETERINARY MEDICINE

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Subject: search.filters.subject.Moringa oleifera

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    Healing potentials of oral moringa oleifera leaves extract and tetracycline on methicillin resistant staphylococcus aureus infected wounds of wistar rats
    (Physiological Society of Nigeria, 2015) Eyarefe, O. D.; Idowu, A.; Afolabi, J. M.
    Summary: The effects of oral dose of aqueous extract of Moringa oleifera and tetracycline antibiotics on cutaneous wounds infected with Staphylococcus aureus were studied in eighteen adult wistar rats (159±31.5g) randomized into three groups: Group A, n = 6, Moringa oleifera-(300 mg/kg). Group B, n = 6, tetracycline (9.4 mg/kg) and Group C, n = 6, Sterile water (control). Six millimetres diameter nape wound, created on each rat under 2% xylazine (5 mg/kg) and 5% ketamine (35 mg/kg), was contaminated with Staphylococcus aureus (108 Colony Forming Unit (CFU). Following infection, treatment was commenced with daily oral dose of test preparations and the wounds were evaluated every other day i.e., day 3, 5, 7, 9, 11, 13 and 15 for wetness (wound exudation), wound edge oedema, hyperaemia, granulation tissues and contraction (diameter). Severe wound exudation existed in all the groups between days 0-3 (p = 1.00). A significantly less (p<0.05) wound exudation was observed at days 3-5 (p = 0.000) and 5-9 (p = 0.003) (Control< Tetracycline Moringa> Tetracycline). Differences in wound diameter was not significant except at days 5-9 (p = 0.013) (Control> Moringa >Tetracycline). Oral doses of Moringa oleifera extract (300mg/kg) and tetracycline (9.4mg/kg) are not effective as antimicrobial or immune-boosting agents to enhance healing of wounds infected with Staphylococcus aureus and hence not recommended for rapid clearance of Staphylococcus aureus infected wounds
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    Haematological and serum biochemical variables in rats treated with ethanol extract of the root of moringa oleifera
    (Biomedical Communications Group, Ibadan, 2014-01) Ola-Davies, O. E.; Olukole, S. G.; Amoo, O. A.
    The haematology and serum biochemical effects of oral administration of the ethanolic extract of the root of Moringa oleifera at 50, 100 and 150 mg/kg were investigated in 30 mated female Wistar rats. The rats were assigned into five groups of six rats each. Group A was given 50mg/kg of the extract; group B, 100mg/kg; group C, 150 mg/kg; group D, 0.2ml of corn oil; and group E, 0.2ml of distilled water. Groups D and E, corn oil and distilled water treatment groups respectively, served as the controls while groups A, B and C were the treatment groups. There was no significant difference (P>0.05) between the two control groups and the treatment groups for the RBC, WBC, PCV, MCV, MCH and MCHC and Hb. However, the mean lymphocyte values for groups B and C were significantly different (P<0.05) from those of group A as well the two control groups. The total protein, albumin, globulin and A/G ratio showed no significant difference (P>0.05) between the two control groups and the treatment groups. There were no significant differences (P>0.05) in the values of AST, ALP, creatinine, urea, GGT, glucose, cholesterol and ALT between the treatment groups and the control groups. It can therefore be concluded that oral administration of ethanolic extract of the root of M. oleifera is harmless to the rats since no adverse effects were detected in haematological and serum biochemical investigations