D-ribose-L-cystein prevents oxidative stress and cardiometabolic syndrome in high-fructose, high-fat-fed rats

Abstract

Cardiometabolic syndrome has been linked with dietary modification. Therefore, we investigated the effects of D-ribose L cysteine (DRLC) in rats fed with high fructose high fat (IFF) diet. Twenty rats (n 5), divided into 4 groups were concurrently exposed to IIFIIF and/or DRLC (250 mg/kg, p.o) during the 8 weeks study. The result showed that compared to control group, HFHF group had significant impairment in lipid and glucose homeo- stasis, increased cardiac xanthine oxidase, systolic blood pressure, heart rate, body weight change and fluid intake. Also, there were significant reductions in HDL-C, cardiac (GPX, NO&GGT), feel intake and relative heart weight in the latter, relative to the former. However, there were no significant differences in most of the observed physical and biochemical changes in IIFIIF DRLC group compared to control. DRLC alone did not disrupt the level of biomarkers. Conclusively, DRLC prevented the manifestation of oxidative stress and cardiometabolic syndrome in IIFIIF diet fed rats.