Peristrophe roxburghiana Leaf Extracts Exhibited Anti-Hypertensive and Antilipidemic Properties in L-Name Hypertensive Rats. Life Sciences

Abstract

Aims Hypertension is a global disease that has been combating the ward health for ages. Perstrophe sax burghiana (P) is used to traditional malivine to treat hypertension and other ailments. The present study ex amined phytochemical constituents, antexidant activities and GC-MS analysis of extracts of PR leaf and alu evaluated their anti-hypertensive and and-lipidemic effects in NG nitro-L-arginine methyl ester (L-NAME) hypertensive rats. Methods Wistar rats were grouped into two groups: control and hypertensive. Hypertension was induced in the hypertensive group by oral gavage of 60 mg/kg bw of L-NAME for 3 works. After induction, the hypertensive group was randomly sub grouped into hypertensive, hypertensive treated and hypertensive untreated groups. There were crally gavaged respectively with 60mg/kg bw of L-NAME, 60mg/kg bw/day of LNAME +200 mg/kg bw of different extracts of PR (aqueous, ethanolic and methanolic extracts) and 60 mg/kg b.w of L- NAME 20 mg/kg bw ramipril for 3 weeks. The blood pressure was memured by tad-cuff method at the third and sixth weeks. Key findings: The results showed that the extracts of Pit significantly decrease blood pressure, pro-atherogeni lipids and themgenic ratios in L-NAME hypertensive rats. White blood cells count, nautcaphil count and creatinine level were also effectively decreased by the extracts. Furthermore, the extracts incresse serum nitric oxide (NO) level, anti-atherogenic lipid, glutathione level, lymphocyte and platelet count in the rats. Significance Extracts of PR leaf decrease blood pressure and increase NO level in LNAME hypertensive rats and also corrected the hyperlipidemis and inflammatory response arising from the reduction in NO bioavailability.